Prescription medication · Nitroimidazole Antibiotic
metronidazole
Also sold as Flagyl. Metronidazole treats infections like trichomoniasis, amebiasis, and certain anaerobic bacterial infections.
Data updated 2026-05-15
- 63,731
- FDA reportsOften reported
- 10
- InteractionsSeveral interactions
- In shortage
- FDA status
What the data shows
metronidazole (Flagyl) is a prescription Nitroimidazole Antibiotic, more reported than most tracked drugs (63,731 FDA reports), with 10 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
metronidazole (Flagyl) is a prescription Nitroimidazole Antibiotic. Metronidazole treats infections like trichomoniasis, amebiasis, and certain anaerobic bacterial infections.
Metronidazole is an antibiotic medicine. It fights bacteria and certain parasites in your body.
Verify with FDA → · CMS NADAC pricing →
Drug Shortage Alert
metronidazole is currently listed as in shortage by the FDA. Affected manufacturer: InfoRLife SA. Status: Limited Availability.
View all drug shortages →Drug Pricing (NADAC)
Generic Price
$0.25/unit
Generic Available
Yes (35 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: METRONIDAZOLE 0.75% CREAM
Same CMS presentation as the headline generic unit price above (2 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: -30% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| February 21, 2024 | $0.3562/GM | - | 1 |
| December 18, 2024 | $0.2494/GM | -30% | 4 |
What it does
Metronidazole treats infections like trichomoniasis, amebiasis, and certain anaerobic bacterial infections.
Common side effects
Nausea, Headache, Loss of appetite
Key warnings
Metronidazole can cause cancer in mice and rats.
The sections below are summarized in plain English from metronidazole's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Metronidazole works by entering the bacteria or parasite and damaging its DNA. This damage stops the bacteria or parasite from growing and multiplying. Eventually, the infection is cleared.
Side Effects (from patient reports)
Based on 63,731 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for metronidazole, by number of reports
- Nausea
Nausea
4,693 reports
- Diarrhoea
Diarrhoea
4,116 reports
- Vomiting
Vomiting
3,283 reports
- Pyrexia
Pyrexia
3,224 reports
- Drug Hypersensitivity
Drug Hypersensitivity
3,138 reports
- Pain
Pain
3,129 reports
- Abdominal Pain
Abdominal Pain
2,980 reports
- Headache
Headache
2,882 reports
- Fatigue
Fatigue
2,876 reports
- Dyspnoea
Dyspnoea
2,238 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for metronidazole each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where metronidazole sits
metronidazole has more FDA adverse-event reports than 78% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is metronidazole; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 63,731 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 1999–2025.
Total Reports
63,731
Reports Mentioning Death
6,727
10.6% of reports — not proof of cause
Hospitalization Reports
26,693
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | NAUSEA | 4,693 |
| 3 | DIARRHOEA | 4,116 |
| 5 | VOMITING | 3,283 |
| 6 | PYREXIA | 3,224 |
| 7 | DRUG HYPERSENSITIVITY | 3,138 |
| 8 | PAIN | 3,129 |
| 9 | ABDOMINAL PAIN | 2,980 |
| 10 | HEADACHE | 2,882 |
| 11 | FATIGUE | 2,876 |
| 12 | DYSPNOEA | 2,238 |
| 13 | DIZZINESS | 2,201 |
| 14 | CONDITION AGGRAVATED | 2,107 |
| 15 | MALAISE | 2,017 |
| 16 | RASH | 1,997 |
| 17 | ACUTE KIDNEY INJURY | 1,846 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Metronidazole can cause cancer in mice and rats. Only use it for the conditions listed in this leaflet. Do not drink alcohol or use products with propylene glycol while taking this medicine, and for 3 days after.
Known Drug Interactions
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Mechanism: Metronidazole may reduce the speed at which your liver clears theophylline from your blood. This can cause the drug to reach levels that are toxic to your body.
Lithium In patients stabilized on relatively high doses of lithium, short-term metronidazole therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity. Serum lithium and serum creatinine levels should be obtained several days after beginning metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication.
Mechanism: Metronidazole can cause lithium to build up in your body, which may lead to lithium poisoning.
Drug Interactions Disulfiram Psychotic reactions have been reported in alcoholic patients who are using metronidazole and disulfiram concurrently. Metronidazole should not be given to patients who have taken disulfiram within the last two weeks (see CONTRAINDICATIONS ).
Mechanism: Combining these two medicines can cause serious mental health problems, such as confusion or psychotic reactions.
Drugs that Inhibit CYP450 Enzymes The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of metronidazole.
Mechanism: Cimetidine slows down how fast your liver breaks down metronidazole, which causes the medicine to stay in your body longer.
Drugs that Induce CYP450 Enzymes The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital, may accelerate the elimination of metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported.
Mechanism: Phenytoin makes your liver clear metronidazole out of your body too quickly, while metronidazole can cause phenytoin to build up to unsafe levels.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I drink alcohol while taking metronidazole?
What should I do if I experience numbness or tingling in my extremities?
Can metronidazole affect my liver?
Does metronidazole interact with other medications?
Can metronidazole cause a yeast infection?
How long does it take for metronidazole to start working?
What if my symptoms get worse while taking metronidazole?
Can metronidazole cause my urine to change color?
Is it safe to take metronidazole if I have kidney problems?
What if I am allergic to metronidazole?
What are the common side effects of metronidazole?
Does metronidazole interact with other medications?
What drug class is metronidazole?
What pregnancy or breastfeeding source fields are listed for metronidazole?
Is metronidazole currently in shortage?
Related Medications in Nitroimidazole Antibiotic
Other drugs grouped near metronidazole - same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with metronidazole →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with metronidazole →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with metronidazole →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with metronidazole →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with metronidazole →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for metronidazole: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 63,731.
- doxycycline hyclate Δ 31 reports · Tetracycline Antibiotic (Antimalarial) 63,762reports
- insulin aspart Δ 195 reports · Rapid-Acting Insulin 63,536reports
- fluoxetine Δ 388 reports · Selective Serotonin Reuptake Inhibitor (SSRI) 64,119reports
- calcium carbonate Δ 673 reports · Calcium Supplement / Antacid 64,404reports
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 10.56%.
- tretinoin Δ 0.02 pts · 7,629 reports · Retinoid (Topical) 10.54%death share
- ramipril Δ 0.02 pts · 119,507 reports · ACE Inhibitor 10.57%death share
- nizatidine Δ 0.05 pts · 1,480 reports · H2 Receptor Antagonist 10.61%death share
- alogliptin Δ 0.06 pts · 3,393 reports · DPP-4 Inhibitor 10.49%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for metronidazole
The FDA label for metronidazole (sold under brand names such as Flagyl) classifies it as a prescription-only medication in the Nitroimidazole Antibiotic class. Metronidazole treats infections like trichomoniasis, amebiasis, and certain anaerobic bacterial infections. Official labeling lists 8 commonly reported side effects, including Nausea, Headache, Loss of appetite.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 63,731 voluntary reports. The database also lists 10 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.25.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 3, 2023
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages