Prescription medication · Proton Pump Inhibitor (PPI)

dexlansoprazole

Name: dexlansoprazole - FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Also sold as Dexilant. This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach).

Compiled by PlainMeds, Drug Information Editorial Process

Data updated 2026-05-15

40,790
FDA reportsModerately reported: 8
InteractionsFew interactions: $5.02
Generic price (NADAC)

What the data shows

dexlansoprazole (Dexilant) is a prescription Proton Pump Inhibitor (PPI), reported at a middle-of-the-pack volume (40,790 FDA reports), with 8 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

dexlansoprazole (Dexilant) is a prescription Proton Pump Inhibitor (PPI). This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach).

Dexlansoprazole (Dexilant) is a medicine that lowers stomach acid. It belongs to a class of drugs called proton pump inhibitors (PPIs).

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Generic Price

$5.02/unit

Generic Available

Yes (4 manufacturers)

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

View Alternatives → Compare with Another Drug → Full Side Effects Report →

What it does

This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach).

Common side effects

Diarrhea, Abdominal pain, Nausea

Key warnings

Dexlansoprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve.

The sections below are summarized in plain English from dexlansoprazole's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Dexlansoprazole works by reducing the amount of acid your stomach makes. It does this by blocking a specific system in your stomach cells. This helps to heal damage caused by stomach acid.

Side Effects (from patient reports)

Based on 40,790 FDA adverse event reports.

Chronic Kidney Disease

16,100
Acute Kidney Injury

7,791
Renal Failure

6,721
End Stage Renal Disease

4,842
Renal Injury

4,339
Fatigue

2,337
Tubulointerstitial Nephritis

2,190
Nausea

2,138
Diarrhoea

1,947
Headache

1,902

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Reports over time

Adverse-event reports filed for dexlansoprazole each year to the FDA Adverse Event Reporting System (FAERS).

Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.

Where dexlansoprazole sits

dexlansoprazole has more FDA adverse-event reports than 69% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.

fewest reports most reports

Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is dexlansoprazole; the line is the median (50th percentile).

FDA Adverse Event Report Analysis

Detailed analysis of 40,790 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2008–2025.

Total Reports

40,790

Reports Mentioning Death

3,607

8.8% of reports — not proof of cause

Hospitalization Reports

6,956

Top Indication

Product Used For Unknown Indication

Gender Distribution

Female 19,176 (68%)

Male 8,896 (32%)

Age Distribution

0–17 138

18–44 2,589

45–64 7,813

65–74 3,785

75+ 2,523

Most Reported Adverse Reactions (FAERS)

#	Reaction	Reports
1	CHRONIC KIDNEY DISEASE	16,100
2	ACUTE KIDNEY INJURY	7,791
3	RENAL FAILURE	6,721
4	END STAGE RENAL DISEASE	4,842
5	RENAL INJURY	4,339
7	FATIGUE	2,337
9	TUBULOINTERSTITIAL NEPHRITIS	2,190
10	NAUSEA	2,138
11	DIARRHOEA	1,947
12	HEADACHE	1,902
13	PAIN	1,902
14	DEATH	1,831
15	DYSPNOEA	1,542
16	GASTROOESOPHAGEAL REFLUX DISEASE	1,424
17	ARTHRALGIA	1,402

Reactions in Death Reports

DEATH 1,827

CHRONIC KIDNEY DISEASE 1,592

RENAL FAILURE 1,331

ACUTE KIDNEY INJURY 1,051

END STAGE RENAL DISEASE 990

TUBULOINTERSTITIAL NEPHRITIS 348

RENAL INJURY 324

CONDITION AGGRAVATED 170

GENERAL PHYSICAL HEALTH DETERIORATION 169

DYSPNOEA 163

Reactions in Hospitalization Reports

CHRONIC KIDNEY DISEASE 945

FATIGUE 932

ACUTE KIDNEY INJURY 901

NAUSEA 796

DYSPNOEA 759

RENAL FAILURE 738

HEADACHE 702

DIARRHOEA 700

PNEUMONIA 693

PAIN 686

Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation

Serious Warnings

Dexlansoprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve. It can also cause kidney problems, severe diarrhea from a Clostridium difficile infection, and bone fractures with long-term use. Some people may have severe skin reactions or lupus. Long-term use may also lead to low vitamin B12 or magnesium levels.

Known Drug Interactions

moderate rifampin

John’s Wort, rifampin : Avoid concomitant use with dexlansoprazole.

Mechanism: Rifampin can cause your body to clear dexlansoprazole much faster than normal, making the stomach medicine less effective. This prevents the drug from working well to treat your symptoms.

minor warfarin

Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs and warfarin concomitantly. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.

Mechanism: Dexlansoprazole can increase the blood-thinning effects of warfarin. This makes your blood take longer to clot and increases the risk of bleeding.

minor methotrexate

Methotrexate Clinical Impact: Concomitant use of PPIs with methotrexate (primarily at high dose) may elevate and prolong serum concentrations of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. No formal drug interaction studies of high-dose methotrexate with PPIs have been conducted [see Warnings and Precautions (5.10)] . Intervention: A temporary withdrawal of dexlansoprazole may be considered in some patients receiving high-dose methotrexate.

Mechanism: Dexlansoprazole can cause methotrexate to stay in your body longer and reach higher levels than normal. This can increase the risk of harmful side effects from the methotrexate.

minor ketoconazole

Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Dexlansoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.

Mechanism: This medicine lowers stomach acid, which ketoconazole needs to dissolve and get into your bloodstream. Without enough acid, your body may not absorb enough of the antifungal medicine to work properly.

minor itraconazole

Mechanism: Dexlansoprazole reduces the amount of acid in your stomach, which is necessary for itraconazole to be absorbed into your body. This can make the antifungal drug less effective at treating infections.

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This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I take this with other medications?

Dexlansoprazole can interact with some medicines. Tell your doctor about all the medicines you take, especially rilpivirine, methotrexate, and warfarin.

How long does it take for this medicine to work?

It may take several days for your symptoms to improve.

Can I crush or chew the capsule?

No, swallow the capsule whole. If you have trouble swallowing, you can open the capsule and mix the pellets with applesauce or water.

What should I do if I experience side effects?

If you experience any bothersome or severe side effects, contact your doctor.

Can I take this medicine long-term?

Long-term use of dexlansoprazole may have some risks. Talk to your doctor about the best duration of treatment for you.

Is it safe to drink alcohol while taking this medication?

It's best to avoid alcohol, as it can worsen your symptoms.

Will this medication interact with any of my supplements?

Tell your doctor about all supplements you are taking, especially iron.

Can I drive or operate machinery while taking this medication?

Dexlansoprazole is not likely to affect your ability to drive or operate machinery.

How often should I see my doctor while taking this medication?

Follow your doctor's recommendations for check-up appointments.

What do the numbers on the capsule mean?

The numbers on the capsule help identify the strength of the medicine.

What are the common side effects of dexlansoprazole?

The registry lists Diarrhea, Abdominal pain, Nausea, Upper respiratory tract infection, Vomiting among the most-reported FAERS reaction terms for dexlansoprazole. The compiled record contains 40,790 FDA adverse-event reports. These counts are not an individual symptom assessment.

Does dexlansoprazole interact with other medications?

The registry has 8 documented interaction rows for dexlansoprazole. Notable source-record pairings include rifampin, warfarin, methotrexate. These rows are not a complete medication review.

What drug class is dexlansoprazole?

dexlansoprazole belongs to the Proton Pump Inhibitor (PPI) drug class. It requires a prescription (Rx). This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach).

What pregnancy or breastfeeding source fields are listed for dexlansoprazole?

The FDA label for dexlansoprazole contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

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