Prescription medication · Anticonvulsant
levetiracetam
Also sold as Keppra. Levetiracetam is used to treat partial-onset seizures in patients 1 month and older.
Data updated 2026-05-15
- 127,698
- FDA reportsOften reported
- 1
- InteractionFew interactions
- 99% less
- Generic vs brandHuge savings
- 2
- Recall records
What the data shows
levetiracetam (Keppra) is a prescription Anticonvulsant, more reported than most tracked drugs (127,698 FDA reports), whose generic costs a fraction of the brand (about 99% less).
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
levetiracetam (Keppra) is a prescription Anticonvulsant. Levetiracetam is used to treat partial-onset seizures in patients 1 month and older.
Levetiracetam is a medicine used to treat seizures. It helps control seizures in adults and children.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$18.94/unit
Generic Price
$0.16/unit
Generic Savings
99%
Generic Available
Yes (57 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: LEVETIRACETAM 1,000 MG TABLET
Same CMS presentation as the headline generic unit price above (3 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: -3.4% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| February 21, 2024 | $0.1936/EA | - | 2 |
| April 17, 2024 | $0.1624/EA | -16.2% | 2 |
| December 18, 2024 | $0.1569/EA | -3.4% | 18 |
What it does
Levetiracetam is used to treat partial-onset seizures in patients 1 month and older.
Common side effects
Sleepiness, Weakness, Infection
Key warnings
Levetiracetam can cause behavior and mood changes, including psychotic symptoms and suicidal thoughts.
The sections below are summarized in plain English from levetiracetam's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Levetiracetam is an antiepileptic drug, but how it works is not fully known. It is thought to affect certain nerve signals in the brain. This helps to reduce seizures.
Side Effects (from patient reports)
Based on 127,698 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for levetiracetam, by number of reports
- Seizure
Seizure
15,308 reports
- Fatigue 5,403
Fatigue
5,403 reports
- Convulsion 4,083
Convulsion
4,083 reports
- Epilepsy 3,996
Epilepsy
3,996 reports
- Somnolence 3,978
Somnolence
3,978 reports
- Fall 3,656
Fall
3,656 reports
- Headache 3,609
Headache
3,609 reports
- Maternal Exposure During Pregnancy 3,535
Maternal Exposure During Pregnancy
3,535 reports
- Dizziness 3,469
Dizziness
3,469 reports
- Nausea 3,465
Nausea
3,465 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for levetiracetam each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where levetiracetam sits
levetiracetam has more FDA adverse-event reports than 89% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is levetiracetam; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 127,698 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2002–2025.
Total Reports
127,698
Reports Mentioning Death
11,586
9.1% of reports — not proof of cause
Hospitalization Reports
47,411
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | SEIZURE | 15,308 |
| 4 | FATIGUE | 5,403 |
| 5 | CONVULSION | 4,083 |
| 6 | EPILEPSY | 3,996 |
| 7 | SOMNOLENCE | 3,978 |
| 8 | FALL | 3,656 |
| 9 | HEADACHE | 3,609 |
| 10 | MATERNAL EXPOSURE DURING PREGNANCY | 3,535 |
| 11 | DIZZINESS | 3,469 |
| 12 | NAUSEA | 3,465 |
| 13 | DRUG INTERACTION | 3,366 |
| 14 | DIARRHOEA | 3,137 |
| 15 | DEATH | 3,126 |
| 16 | VOMITING | 3,113 |
| 17 | CONDITION AGGRAVATED | 3,070 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Levetiracetam can cause behavior and mood changes, including psychotic symptoms and suicidal thoughts. Watch for new or worsening depression, suicidal thoughts, or unusual changes in mood or behavior. Levetiracetam can also cause sleepiness and fatigue, so be careful when driving or operating machinery. Serious skin reactions and allergic reactions are possible. Do not suddenly stop taking this medicine, as it can cause withdrawal seizures.
Known Drug Interactions
(7.3) Levetiracetam: Brivaracetam had no added therapeutic benefit when co-administered with levetiracetam. 7.4 Levetiracetam Brivaracetam provided no added therapeutic benefit to levetiracetam when the two drugs were co-administered [see Clinical Studies (14)] .
Mechanism: These two seizure medicines are very similar and work on the same parts of the brain. Taking them both at the same time does not provide any extra help in controlling seizures.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What should I avoid while taking levetiracetam?
Can I drink alcohol while taking levetiracetam?
What if I have kidney problems?
How often will I see the doctor?
Can I stop taking levetiracetam suddenly?
What if I experience side effects?
Does levetiracetam interact with other medications?
How long does it take for levetiracetam to start working?
What strengths does levetiracetam come in?
Is there a generic version of levetiracetam?
What are the common side effects of levetiracetam?
Does levetiracetam interact with other medications?
What drug class is levetiracetam?
Is there a generic version of levetiracetam?
What pregnancy or breastfeeding source fields are listed for levetiracetam?
Has levetiracetam been recalled?
Active Recalls
LABELING: LABEL MIX-UP: The infusion bag is incorrectly labeled as Levetiracetam in 0.82% Sodium Chloride Injection 500 mg/100 mL, while the aluminum overwrap packaging correctly identifies the product as Levetiracetam in 0.75% Sodium Chloride Injection 1,000 mg/100 mL.
Dr. Reddy's Laboratories, Inc.
CGMP Deviations: Firm went out of business and could no longer continue stability studies.
Akorn, Inc.
Related Medications in Anticonvulsant
Other drugs grouped near levetiracetam - same-class peers and common alternatives.
brivaracetam
Briviact
Brivaracetam is a medicine used to treat partial-onset seizures.
Compare with levetiracetam →
cannabidiol
Epidiolex
Epidiolex is a medicine that contains cannabidiol.
Compare with levetiracetam →
carbamazepine
Tegretol
Carbamazepine is a medicine used to control seizures and treat nerve pain.
Compare with levetiracetam →
cenobamate
Xcopri
Xcopri is a medicine used to treat partial-onset seizures in adults.
Compare with levetiracetam →
clobazam
Onfi, Sympazan
Clobazam oral suspension is a medicine used with other medicines to treat seizures caused by Lennox-Gastaut syndrome.
Compare with levetiracetam →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for levetiracetam: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 127,698.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 9.07%.
- ivermectin Δ 0.02 pts · 5,936 reports · Antiparasitic 9.10%death share
- valacyclovir Δ 0.06 pts · 39,048 reports · Antiviral 9.01%death share
- meclizine Δ 0.06 pts · 15,616 reports · Antihistamine / Antiemetic 9.13%death share
- valproate Δ 0.06 pts · 19,772 reports · Anticonvulsant / Mood Stabilizer 9.01%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for levetiracetam
The FDA label for levetiracetam (sold under brand names such as Keppra) classifies it as a prescription-only medication in the Anticonvulsant class. Levetiracetam is used to treat partial-onset seizures in patients 1 month and older. Official labeling lists 9 commonly reported side effects, including Sleepiness, Weakness, Infection.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 127,698 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $0.16 versus $18.94 for the brand - a 99% generic savings.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 2 recall records on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: November 21, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages