doxycycline
Brand names: Vibramycin, Doryx
Doxycycline is an antibiotic medicine. It fights bacteria in your body to treat different kinds of infections.
Drug Shortage Alert
doxycycline is currently listed as to be discontinued by the FDA. Affected manufacturer: Teva Pharmaceuticals USA, Inc..
View all drug shortages →Drug Pricing (NADAC)
Generic Price
$0.20/unit
Generic Available
Yes (34 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Doxycycline treats many types of infections caused by bacteria.
Common side effects
Nausea, Vomiting, Diarrhea
Key warnings
Doxycycline can cause permanent tooth discoloration if used during tooth development (pregnancy, infancy, childhood up to 8 years old).
How It Works
Doxycycline belongs to a class of drugs called tetracycline antibiotics. It works by stopping the growth of bacteria. This helps your body fight off the infection.
How to Take It
Take doxycycline exactly as your doctor tells you. The usual dose for adults is 200 mg on the first day, then 100 mg each day after that. For some severe infections, you may need 100 mg every 12 hours. Drink plenty of water when taking this medicine to avoid throat irritation. You can take doxycycline with food or milk if it upsets your stomach.
Pregnancy & Breastfeeding
Doxycycline can harm an unborn baby. Do not use this medicine if you are pregnant. Doxycycline can pass into breast milk and may affect bone and tooth development in the nursing infant. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Storage
Store doxycycline at room temperature, away from light and moisture.
Side Effects (from patient reports)
Based on 41,519 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 64,488 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2003–2025.
Total Reports
64,488
Death-Related Reports
6,297
Hospitalization Reports
20,682
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DRUG INEFFECTIVE | 5,031 |
| 2 | NAUSEA | 4,769 |
| 3 | OFF LABEL USE | 4,436 |
| 4 | FATIGUE | 4,419 |
| 5 | RASH | 3,945 |
| 6 | DIARRHOEA | 3,843 |
| 7 | PAIN | 3,835 |
| 8 | DYSPNOEA | 3,798 |
| 9 | HEADACHE | 3,771 |
| 10 | VOMITING | 3,669 |
| 11 | DRUG HYPERSENSITIVITY | 3,635 |
| 12 | MALAISE | 2,832 |
| 13 | CONDITION AGGRAVATED | 2,797 |
| 14 | DIZZINESS | 2,784 |
| 15 | PRURITUS | 2,761 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Doxycycline can cause permanent tooth discoloration if used during tooth development (pregnancy, infancy, childhood up to 8 years old). It can also cause increased pressure inside the skull. Tell your doctor right away if you have blurred vision, double vision, or a severe headache.
Known Drug Interactions
Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.
Mechanism: Both of these medicines belong to the same family of antibiotics, which can increase the risk of side effects without helping you get better faster.
What to do: Avoid taking these two antibiotics together unless your doctor tells you otherwise.
Doxycycline Administered with rifampin (10 mg/kg daily) Decrease exposure Irinotecan Administered with an antibiotic regimen including rifampin (450 mg/day), isoniazid (300 mg/day), and streptomycin (0.5 g/day) IM Prevention or Management: Avoid the use of rifampin, a strong CYP3A4 inducer, if possible.
Mechanism: Rifampin speeds up how quickly your body breaks down doxycycline, which makes the antibiotic less effective at fighting infections.
What to do: Avoid taking these two drugs together if possible so the antibiotic can work correctly.
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
Mechanism: Carbamazepine causes your body to process and get rid of doxycycline faster than it should.
What to do: Your doctor may need to adjust your doxycycline dose or monitor how well the treatment is working.
Absorption of tetracyclines is impaired by bismuth subsalicylate.
Mechanism: Bismuth subsalicylate prevents your body from properly absorbing the antibiotic into your bloodstream.
What to do: Talk to your doctor about how to time these medications so the antibiotic can be absorbed correctly.
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
Mechanism: Phenytoin speeds up how quickly your body breaks down and removes doxycycline from your system.
What to do: Your healthcare provider may need to change your dose of doxycycline to ensure it stays effective.
Common Questions
Can I take doxycycline with food?
What should I do if I experience severe diarrhea while taking doxycycline?
Can doxycycline make birth control pills less effective?
How long should I take doxycycline?
Can I drink alcohol while taking doxycycline?
What should I do if I get a rash while taking doxycycline?
Can doxycycline cause sun sensitivity?
Is it safe to take doxycycline if I have kidney problems?
Can doxycycline be used to treat a cold or the flu?
What does it mean if I am allergic to tetracyclines?
What are the common side effects of doxycycline?
Does doxycycline interact with other medications?
What drug class is doxycycline?
Is doxycycline safe during pregnancy?
Has doxycycline been recalled?
Is doxycycline currently in shortage?
Active Recalls
Failed dissolution specifications: Stability testing found that the lot did not meet dissolution specifications.
Acella Pharmaceuticals, LLC
Related Medications in Tetracycline Antibiotic
Other drugs grouped near doxycycline — same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with doxycycline →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with doxycycline →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with doxycycline →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with doxycycline →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with doxycycline →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
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Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Related Health & Safety Data
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What the FDA Data Shows for doxycycline
The FDA label for doxycycline (sold under brand names such as Vibramycin, Doryx) classifies it as a prescription-only medication in the Tetracycline Antibiotic class. Doxycycline treats many types of infections caused by bacteria. Official labeling lists 5 commonly reported side effects, including Nausea, Vomiting, Diarrhea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 41,519 voluntary reports. The database also lists 9 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $0.20.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: January 14, 2026
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages