leuprolide
Brand names: Lupron
VABRINTY is a medicine that treats advanced prostate cancer. It contains leuprolide, which lowers testosterone levels.
Drug Pricing (NADAC)
Generic Price
$267.68/unit
Generic Available
Yes (8 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
VABRINTY treats advanced prostate cancer in men.
Common side effects
Feeling tired or weak, Hot flashes or sweats, Testicles shrinking
Key warnings
VABRINTY can cause a temporary increase in testosterone levels, which may worsen symptoms at first.
How It Works
VABRINTY contains leuprolide, which is a GnRH agonist. It lowers the amount of testosterone your body makes. This can help to slow the growth of prostate cancer cells.
How to Take It
VABRINTY is given as a shot under the skin by a healthcare provider. You will get a shot every 1, 3, 4, or 6 months, depending on the dose your doctor prescribes. The injection site should be changed each time. The shot is usually given in the upper or mid-abdominal area.
Pregnancy & Breastfeeding
VABRINTY can harm an unborn baby. Females should not take VABRINTY if they are pregnant or may become pregnant. It is not known if VABRINTY passes into breast milk, so talk to your doctor about breastfeeding.
Missed Dose
If you miss a dose of VABRINTY, contact your doctor right away to reschedule your injection. It is important to get your injections on time.
Storage
Store VABRINTY in the refrigerator between 36°F to 46°F. Before mixing, it can be stored at room temperature (59°F to 86°F) for up to 8 weeks.
Side Effects (from patient reports)
Based on 597 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 1,385 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2005–2025.
Total Reports
1,385
Death-Related Reports
119
Hospitalization Reports
457
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DRUG INEFFECTIVE | 106 |
| 2 | FATIGUE | 82 |
| 3 | OFF LABEL USE | 67 |
| 4 | NAUSEA | 61 |
| 5 | HEADACHE | 58 |
| 6 | MALIGNANT NEOPLASM PROGRESSION | 53 |
| 7 | DISEASE PROGRESSION | 50 |
| 8 | FEBRILE NEUTROPENIA | 43 |
| 9 | PRODUCT STORAGE ERROR | 41 |
| 10 | HOT FLUSH | 36 |
| 11 | PRODUCT USE IN UNAPPROVED INDICATION | 36 |
| 12 | ANAEMIA | 35 |
| 13 | VOMITING | 35 |
| 14 | TREATMENT FAILURE | 34 |
| 15 | DIARRHOEA | 33 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
VABRINTY can cause a temporary increase in testosterone levels, which may worsen symptoms at first. This could include bone pain, nerve problems, or trouble urinating. VABRINTY may also increase your risk of high blood sugar, diabetes, heart problems, and seizures. Tell your doctor right away if you have signs of a severe skin reaction.
Common Questions
How often will I get the VABRINTY injection?
Will VABRINTY cure my prostate cancer?
What should I do if I have side effects?
Can VABRINTY affect my fertility?
Will my prostate cancer symptoms get worse when I start VABRINTY?
Does VABRINTY interact with other medications?
Can VABRINTY cause diabetes?
Can VABRINTY cause heart problems?
What if I have a history of seizures?
Is VABRINTY safe for older adults?
What are the common side effects of leuprolide?
What drug class is leuprolide?
Is leuprolide safe during pregnancy?
Related Medications in GnRH Agonist
Other drugs grouped near leuprolide — same-class peers and common alternatives.
abiraterone
Zytiga
Abiraterone (Zytiga) is a medicine used with prednisone to treat prostate cancer that has spread.
Compare with leuprolide →
anastrozole
Arimidex
Anastrozole is a medicine used to treat breast cancer in women after menopause.
Compare with leuprolide →
bazedoxifene/conjugated estrogens
Duavee
Duavee is a combination medicine containing estrogen and a drug that blocks estrogen in some parts of the body.
Compare with leuprolide →
cabergoline
Dostinex
Cabergoline is a medicine that helps lower the amount of prolactin in your body.
Compare with leuprolide →
clomiphene
Clomid, Serophene
Clomiphene citrate is a medicine that helps women ovulate.
Compare with leuprolide →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Related Health & Safety Data
🩺 Find a Doctor
Search prescribers for GnRH Agonist
🏨 Hospital Quality
CMS hospital ratings, safety scores & patient outcomes
💊 Supplement Data
NIH DSLD — check supplement ingredients & label claims
🍽️ Food Safety Alerts
FDA recalls, inspections & outbreak investigations
⚠️ Product Recalls
FDA, CPSC & NHTSA recall search
💉 Procedure Costs
Medicare procedure pricing for 9,297 procedures
Save on leuprolide
Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.
Disclosure: This link may earn us a commission at no extra cost to you. See our terms.
What the FDA Data Shows for leuprolide
The FDA label for leuprolide (sold under brand names such as Lupron) classifies it as a prescription-only medication in the GnRH Agonist class. VABRINTY treats advanced prostate cancer in men. Official labeling lists 3 commonly reported side effects, including Feeling tired or weak, Hot flashes or sweats, Testicles shrinking.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 597 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS shows a generic unit cost of $267.68.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: June 1, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages