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Prescription medicine

Propranolol Brand names: Inderal, Innopran, Hemangeol

Propranolol (Inderal) is a prescription medicine with an FDA approval on record since 1967. FDA's NDC Directory lists it from 42 generic labelers, and pharmacies paid $0.0493 per propranolol 20 mg tablet in the October 7, 2026 NADAC survey.

  • Generic listed
  • In shortage

Check it at the source: the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.); the NDA 16418 record on Drugs@FDA; every propranolol label on DailyMed.

Highlights of the record

FDA label of January 15, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026

Used for

From the label: indications and usage

Hypertension Propranolol hydrochloride tablets are indicated in the management of hypertension.

Forms and strengths

  • 10 mg
  • 20 mg
  • 40 mg
  • 60 mg
  • 80 mg
  • 120 mg
  • 160 mg
  • 1 mg/ml
  • 4.28 mg/ml
  • 20 mg/5ml
  • 40 mg/5ml

Tablet; extended-release capsule; solution; injection (solution); injection.

On the market

Earliest approval on file
November 13, 1967 Inderal, Wyeth Pharms; Drugs@FDA’s file, where older or withdrawn approvals can be missing
Generic approvals
77 first July 30, 1985; 24 with a marketed status in Drugs@FDA
Labelers listed (NDC)
45 of which 42 under generic applications, 3 under brand applications, repackagers included
Last listed patent
October 16, 2028 Hemangeol oral solution; not a generic launch date

Supply and safety

Pharmacy cost (NADAC)
$0.0493 per tablet Propranolol 20 mg tablet
Shortage (FDA)
1 of 2 presentations limited or unavailable updated September 18, 2026
Recalls by its makers (FDA)
4 since 2012 0 Class I among all firms' recalls; latest January 26, 2022; 8 more by firms not listed as its makers
FAERS reports
71,660 through July 30, 2026

What is propranolol used for?

From the label: indications and usage

Hypertension Propranolol hydrochloride tablets are indicated in the management of hypertension. It may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol hydrochloride tablets are not indicated in the management of hypertensive emergencies. Angina Pectoris Due to Coronary Atherosclerosis Propranolol hydrochloride tablets are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. Atrial Fibrillation Propranolol hydrochloride tablets are indicated to control ventricular rate in patients with atrial fibrillation and a rapid ventricular response. […]

Conditions named in the indications of propranolol's FDA labels, with every medicine labeled for each:

From other propranolol labels

High blood pressure: INDICATIONS AND USAGE Hypertension Propranolol hydrochloride tablets are indicated in the management of hypertension.

Migraine: Migraine Propranolol hydrochloride tablets are indicated for the prophylaxis of common migraine headache.

FDA pharmacologic class: beta-Adrenergic Blocker.

Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed

What does the patient leaflet for propranolol say first?

The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.

From the patient leaflet: What is the most important information I should know about HEMANGEOL?

HEMANGEOL can cause serious side effects, including: Low blood sugar (hypoglycemia), especially if your child is not taking feedings, or is vomiting. HEMANGEOL may make it more difficult to recognize the signs and symptoms of low blood sugar in your child. To help reduce the risk of low blood sugar with HEMANGEOL: Give HEMANGEOL during or shortly after feeding your child. Feed your child regularly during treatment. Tell your doctor if your child has a poor appetite. If your child is not taking feedings, for example, due to an illness or vomiting, do not give HEMANGEOL until your child is taking feedings normally again. If your child has any of the signs or symptoms of low blood sugar listed below during treatment with HEMANGEOL, stop giving your child HEMANGEOL, call your healthcare provider immediately or go to the emergency room. If the child is conscious, give him/her a drink of liquid containing sugar. Signs or symptoms of low blood sugar include: pale, blue or purple skin color, sweating, irritability, crying for no apparent reason, irregular or fast heartbeat, poor feeding, low body temperature, unusual sleepiness, seizures, breathing stops for short periods of time, and loss of consciousness.

From the patient leaflet: How should I store HEMANGEOL?

Store HEMANGEOL at room temperature between 68 o F to 77 o F (20 o C to 25 o C). Do not freeze. Do not shake before use. Safely throw away any opened bottle of HEMANGEOL after 2 months, even if there is medicine left in the bottle. Keep HEMANGEOL and all medicines out of the reach of children.

Source: FDA drug label (HEMANGEOL), Pierre Fabre Pharmaceuticals, Inc., effective June 25, 2026 (SPL set b6f9dd2a-632b-87eb-70f0-b2064d7ed48a), via openFDA; the full label on DailyMed

Is there a generic for propranolol (Inderal)?

The FDA approved the first generic propranolol on July 30, 1985. 77 generic applications are approved; 24 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.

FDA's NDC Directory lists propranolol from 42 labelers under a generic (ANDA) application and from 3 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.

The Orange Book lists no patent for Inderal LA capsules; a patent listed only for Hemangeol oral solution runs to October 16, 2028. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.

  • 1967 earliest approval on file
  • 1985 first generic approved
  • 2028 last listed patent
  • 2023 to now in shortage
  • red ticks recalls

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What do pharmacies pay for propranolol (Inderal)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.0493 per Propranolol 20 mg tablet, down 17% from $0.0594 on October 8, 2025. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

  • Propranolol 20 mg tablet (generic)
  • Inderal xl 80 mg capsule (brand)
$69.59
$0.0493
January 2024October 2026
NADAC per unit, October 7, 2026
Strength and formBrand or genericPharmacy cost30 tablets, or one pen or vial12-month change
Propranolol 10 mg tabletGeneric$0.0466 per tablet$1.40-13%
Propranolol 20 mg tabletGeneric$0.0493 per tablet$1.48-17%
Propranolol 20 mg/5 mL solutionGeneric$0.0922 per mLn/a-2%
Propranolol 40 mg tabletGeneric$0.0766 per tablet$2.30-4%
Propranolol 40 mg/5 mL solutionGeneric$0.133 per mLn/an/a
Propranolol 60 mg tabletGeneric$0.159 per tablet$4.76+8%
Propranolol 80 mg tabletGeneric$0.159 per tablet$4.77+5%
Propranolol ER 120 mg capsuleGeneric$0.196 per capsule$5.87-6%
Propranolol ER 160 mg capsuleGeneric$0.305 per capsule$9.15-1%
Propranolol ER 60 mg capsuleGeneric$0.170 per capsule$5.10-5%
Propranolol ER 80 mg capsuleGeneric$0.191 per capsule$5.72-3%
Inderal xl 80 mg capsuleBrand$68.70 per capsule many times the lowest per-tablet cost; NADAC records the price, not why$2,061.11-1%
Innopran xl 80 mg capsuleBrand$68.70 per capsule many times the lowest per-tablet cost; NADAC records the price, not why$2,061.11-1%

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

Is propranolol in shortage?

The FDA Drug Shortage Database lists 1 of 2 propranolol presentations as limited or unavailable (updated September 18, 2026); the first entry was posted on October 31, 2023. 1 more presentation is on the list as available.

PresentationCompanyStatusUpdated
Propranolol Hydrochloride, Injection, 1 mg/1 mL (NDC 0143-9872-10)Hikma Pharmaceuticals USA, Inc.CurrentSeptember 18, 2026
Propranolol Hydrochloride, Injection, 1 mg/1 mL (NDC 63323-604-01)Fresenius Kabi USA, LLCCurrentSeptember 15, 2026

Every propranolol presentation in the FDA shortage database

Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026

Has propranolol been recalled?

The FDA's Enforcement Report lists 12 recalls naming propranolol since 2012: 0 Class I (the most serious), 12 Class II, 0 Class III; 0 still ongoing. 8 of them are by firms that FDA's NDC Directory does not list as a maker of propranolol and that hold no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.

StartedClassCompanyReason
January 26, 2022Class IICARDINAL HEALTHCARECGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions.
August 13, 2014Class IIFresenius Kabi USA, LLCCGMP Deviations: Citations given to API supplier by the Italian Health Agency AIFA for several critical deficiencies which caused a recall of the API lot used …
July 9, 2014Class IIGyma Laboratories Of Amer,Inc not a listed makercGMP Deviations: GYMA laboratories Inc. has recalled multiple Active Pharmaceutical Ingredients manufactured in Italy upon receipt of a Rapid Alert …
August 6, 2013Class IITeva Pharmaceuticals USA, Inc.Failed Tablet/Capsule Specification: Teva is recalling certain lots of Propanolol HCl Tablets, 10 mg due to the potential of some tablets not conforming to …
July 2, 2013Class IIAidapak Services, LLC not a listed makerLabeling: Label Mixup; PROPRANOLOL HCL, Tablet, 10 mg may be potentially mislabeled as PIOGLITAZONE HCL, Tablet, 15 mg, NDC 00093204856, Pedigree: AD52778_70 …
July 2, 2013Class IIAidapak Services, LLC not a listed makerLabeling: Label Mixup; PROPRANOLOL HCL, Tablet, 10 mg may be potentially mislabeled as PERPHENAZINE, Tablet, 16 mg, NDC 00781104901, Pedigree: AD21790_31, EXP …
July 2, 2013Class IIAidapak Services, LLC not a listed makerLabeling: Label Mixup; PROPRANOLOL HCL Tablet, 5 mg (1/2 of 10 mg) may be potentially mislabeled as LITHIUM CARBONATE ER, Tablet, 225 mg (1/2 of 450 mg), NDC …
July 2, 2013Class IIAidapak Services, LLC not a listed makerLabeling: Label Mixup; PROPRANOLOL HCL Tablet, 10 mg may be potentially mislabeled as LACTOBACILLUS ACIDOPHILUS, Capsule, NDC 54629011101, Pedigree: AD65311_4 …

Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026

What does the propranolol label say about other medicines?

The propranolol label names 55 other medicines in its interaction, contraindication or warning sections. The labels of 45 other medicines name propranolol. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Medicine namedSectionWhat the label says
Alprazolamdrug interactionsThe pharmacokinetics of oxazepam, triazolam, lorazepam, and alprazolam are not affected by co-administration of propranolol.
Amiodaronedrug interactionsSubstrates or Inhibitors of CYP2D6 Blood levels and/or toxicity of propranolol may be increased by co-administration with substrates or inhibitors of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Bupropiondrug interactionsImpact of Other Drugs on Propranolol CYP2D6, CYP1A2 and CYP2C19 Inhibitors: CYP2D6 inhibitors (e.g. bupropion, fluoxetine, paroxetine, quinidine), CYP1A2 inhibitors (e.g., ciprofloxacin, enoxamine, fluvoxamine) and CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) increase exposure to propranolol when …
Chlorpromazinedrug interactionsCo-administration of chlorpromazine with propranolol resulted in a 70% increase in propranolol plasma level.
Cholestyraminedrug interactionsLipid Lowering Drugs Co-administration of cholestyramine or colestipol with propranolol resulted in up to 50% decrease in propranolol concentrations.
Cimetidinedrug interactionsSubstrates or Inhibitors of CYP2D6 Blood levels and/or toxicity of propranolol may be increased by co-administration with substrates or inhibitors of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Ciprofloxacindrug interactionsSubstrates or Inhibitors of CYP1A2 Blood levels and/or toxicity of propranolol may be increased by co-administration with substrates or inhibitors of CYP1A2, such as imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Clonidinedrug interactionsThe antihypertensive effects of clonidine may be antagonized by beta-blockers.
Colestipoldrug interactionsLipid Lowering Drugs Co-administration of cholestyramine or colestipol with propranolol resulted in up to 50% decrease in propranolol concentrations.
Diazepamdrug interactionsBenzodiazepines Propranolol can inhibit the metabolism of diazepam, resulting in increased concentrations of diazepam and its metabolites.
Digoxinwarnings and precautionsThe concomitant use of beta-adrenergic blockers and non-dihydropyridine calcium channel blockers (e.g., verapamil and diltiazem), digoxin or clonidine increases the risk of significant bradycardia.
Diltiazemdrug interactionsCo-administration of propranolol and diltiazem in patients with cardiac disease has been associated with bradycardia, hypotension, high-degree heart block, and heart failure.
Dobutaminedrug interactionsIsoproterenol and Dobutamine Propranolol is a competitive inhibitor of beta-receptor agonists, and its effects can be reversed by administration of such agents, e.g., dobutamine or isoproterenol.
Doxazosindrug interactionsPostural hypotension has been reported in patients taking both beta-blockers and terazosin or doxazosin.

Every other medicine the propranolol label names

Medicine namedSectionWhat the label says
Epinephrinedrug interactionsInotropic Agents Patients on long-term therapy with propranolol may experience uncontrolled hypertension if administered epinephrine as a consequence of unopposed alpha-receptor stimulation.
Fluconazoledrug interactions… co-administration with substrates or inhibitors of CYP2C19, such as fluconazole, cimetidine, fluoxetine, fluvoxamine, tenioposide, and tolbutamide.
Fluoxetinedrug interactions… or inhibitors of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Fluvastatindrug interactionsPropranolol did not have an effect on the pharmacokinetics of fluvastatin.
Fluvoxaminedrug interactions… inhibitors of CYP1A2, such as imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Glucagonwarnings and precautionsIn these patients, consider other medications (e.g., intravenous fluids, glucagon).
Haloperidoldrug interactionsNeuroleptic Drugs Hypotension and cardiac arrest have been reported with the concomitant use of propranolol and haloperidol.
Imipraminedrug interactions… co-administration with substrates or inhibitors of CYP1A2, such as imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Indomethacindrug interactionsAdministration of indomethacin with propranolol may reduce the efficacy of propranolol in reducing blood pressure and heart rate.
Isoniaziddrug interactions… CYP1A2, such as imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Isoproterenoldrug interactionsIsoproterenol and Dobutamine Propranolol is a competitive inhibitor of beta-receptor agonists, and its effects can be reversed by administration of such agents, e.g., dobutamine or isoproterenol.
Lansoprazoledrug interactionsNo interactions were observed with either ranitidine or lansoprazole.
Lidocainedrug interactionsThe metabolism of lidocaine is inhibited by co-administration of propranolol, resulting in a 25% increase in lidocaine concentrations.
Lorazepamdrug interactionsThe pharmacokinetics of oxazepam, triazolam, lorazepam, and alprazolam are not affected by co-administration of propranolol.
Lovastatindrug interactionsCo-administration of propranolol with lovastatin or pravastatin, decreased 18% to 23% the AUC of both, but did not alter their pharmacodynamics.
Metoclopramidedrug interactionsCo-administration of metoclopramide with the long-acting propranolol did not have a significant effect on propranolol’s pharmacokinetics.
Montelukastdrug interactionsCYP1A2 and CYP2C19 Inducers: CYP1A2 inducers (e.g., phenytoin, montelukast, smoking) and CYP2C19 inducers (e.g. rifampin) decrease the plasma levels of propranolol resulting in a loss of efficacy …
Nicardipinedrug interactionsCalcium Channel Blockers The mean C max and AUC of propranolol are increased, respectively, by 50% and 30% by co-administration of nisoldipine and by 80% and 47%, by co-administration of nicardipine.
Nifedipinedrug interactionsThe mean C max and AUC of nifedipine are increased by 64% and 79%, respectively, by co-administration of propranolol.
Nisoldipinedrug interactionsCalcium Channel Blockers The mean C max and AUC of propranolol are increased, respectively, by 50% and 30% by co-administration of nisoldipine and by 80% and 47%, by co-administration of nicardipine.
Omeprazoledrug interactionsNo interaction was observed with omeprazole.
Oxazepamdrug interactionsThe pharmacokinetics of oxazepam, triazolam, lorazepam, and alprazolam are not affected by co-administration of propranolol.
Paroxetinedrug interactions… of CYP2D6, such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Phenobarbitaldrug interactionsInducers of Hepatic Drug Metabolism Blood levels of propranolol may be decreased by co-administration with inducers such as rifampin, ethanol, phenytoin, and phenobarbital.
Phenytoindrug interactionsInducers of Hepatic Drug Metabolism Blood levels of propranolol may be decreased by co-administration with inducers such as rifampin, ethanol, phenytoin, and phenobarbital.
Pravastatindrug interactionsCo-administration of propranolol with lovastatin or pravastatin, decreased 18% to 23% the AUC of both, but did not alter their pharmacodynamics.
Prazosindrug interactionsAlpha Blockers Prazosin has been associated with prolongation of first dose hypotension in the presence of beta-blockers.
Propafenonedrug interactionsCardiovascular Drugs Antiarrhythmics The AUC of propafenone is increased by more than 200% by co-administration of propranolol.
Quinidinedrug interactions… such as amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Ranitidinedrug interactionsNo interactions were observed with either ranitidine or lansoprazole.
Rifampindrug interactionsInducers of Hepatic Drug Metabolism Blood levels of propranolol may be decreased by co-administration with inducers such as rifampin, ethanol, phenytoin, and phenobarbital.
Ritonavirdrug interactions… amiodarone, cimetidine, delavudin, fluoxetine, paroxetine, quinidine, and ritonavir.
Rizatriptandrug interactions… fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Terazosindrug interactionsPostural hypotension has been reported in patients taking both beta-blockers and terazosin or doxazosin.
Theophyllinedrug interactions… imipramine, cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Thioridazinedrug interactionsNeuroleptic Drugs Co-administration of long-acting propranolol at doses greater than or equal to 160 mg/day resulted in increased thioridazine plasma concentrations ranging from 55% to 369% and …
Triazolamdrug interactionsThe pharmacokinetics of oxazepam, triazolam, lorazepam, and alprazolam are not affected by co-administration of propranolol.
Verapamildrug interactionsThere have been reports of significant bradycardia, heart failure, and cardiovascular collapse with concurrent use of verapamil and beta-blockers.
Warfarindrug interactionsWarfarin Concomitant administration of propranolol and warfarin has been shown to increase warfarin bioavailability and increase prothrombin time.
Zileutondrug interactions… cimetidine, ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.
Zolmitriptandrug interactions… ciprofloxacin, fluvoxamine, isoniazid, ritonavir, theophylline, zileuton, zolmitriptan, and rizatriptan.

Other labels that name propranolol

Check propranolol against other medicines

Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed

What do FAERS reports show for propranolol?

The FDA Adverse Event Reporting System holds 71,660 reports that list propranolol among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 7,184 are coded as a death and 21,992 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Reports received each year

The most reported reactions

  • Off Label Use (a use or a product term, not a reaction)7,918
  • Drug Ineffective (a use or a product term, not a reaction)5,616
  • Nausea (named in the label)4,552
  • Headache3,962
  • Fatigue (named in the label)3,912
  • Diarrhoea (named in the label)3,294
  • Dizziness3,222
  • Product Use In Unapproved Indication (a use or a product term, not a reaction)3,114

Side effects: the label's list and every FAERS reaction

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What else is labeled for the same conditions as propranolol?

75 other medicines are given the same way (oral) and in the same FDA class as propranolol or labeled mainly for the same use (high blood pressure), the same class first. High blood pressure lists all 88 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

MedicineShared indicationGeneric labelers (oral)Pharmacy costShortage
MetoprololHigh blood pressure, Angina64 labelers$0.085 per tablet 100 mg tabletA presentation being discontinued
CarvedilolHigh blood pressure41 labelers$0.0179 per tablet 6.25 mg tabletNo current entry
AtenololHigh blood pressure, Angina35 labelers$0.0217 per tablet 25 mg tabletNo current entry
LabetalolHigh blood pressure31 labelers$0.215 per tablet 300 mg tabletNo current entry
NebivololHigh blood pressure23 labelers$0.141 per tablet 10 mg tabletA presentation being discontinued
NadololHigh blood pressure, Angina16 labelers$0.147 per tablet 20 mg tabletNo current entry
BisoprololHigh blood pressure24 labelers$0.114 per tablet 5 mg tabletNo current entry
Bisoprolol and hydrochlorothiazideHigh blood pressure11 labelers$0.209 per tablet 10-6.25 mg tabletNo current entry

Every medicine labeled for the same conditions as propranolol

Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)

How does propranolol compare with medicines for the same use?

28 side-by-side pages set propranolol beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.

What next?

Alternatives to propranolol
75 medicines for the same use
Other beta blockers
the pharmacologic class, with prices and generics
Propranolol side effects
the label's list beside FAERS reports
Propranolol shortage record
every presentation, company and date
Check an interaction
what two or more labels say about each other