Prescription medication · Opioid Analgesic Combination

acetaminophen/oxycodone

Name: acetaminophen/oxycodone - FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Also sold as Percocet. Percocet is used to manage severe pain.

Compiled by PlainMeds, Drug Information Editorial Process

Data updated 2026-05-15

247,238
FDA reports: 23
InteractionsSeveral interactions: $36.10
Generic price (NADAC)

What the data shows

acetaminophen/oxycodone (Percocet) is a prescription Opioid Analgesic Combination, with 247,238 FDA adverse-event reports on file, with 23 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

acetaminophen/oxycodone (Percocet) is a prescription Opioid Analgesic Combination. Percocet is used to manage severe pain.

Percocet is a strong pain medicine. It contains acetaminophen and oxycodone, an opioid.

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Drug Pricing (NADAC)

Generic Price

$36.10/unit

Generic Available

Yes (0 manufacturers)

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

Percocet is used to manage severe pain.

Common side effects

Lightheadedness, Dizziness, Drowsiness

Key warnings

Percocet has a boxed warning.

The sections below are summarized in plain English from acetaminophen/oxycodone's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Oxycodone works in the brain to block pain signals. Acetaminophen also helps to reduce pain and fever. Together, they provide stronger pain relief.

Side Effects (from patient reports)

Based on 247,238 FDA adverse event reports.

Tiredness

34,486
Feeling sick to your stomach

29,571
Head pain

28,378
Aches

28,322
Loose stools

23,628
Difficulty breathing

22,691
Joint pain

22,204
Throwing up

20,752
Fever

19,561
Skin irritation

17,645

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Serious Warnings

Percocet has a boxed warning. It can cause addiction, abuse, and misuse, leading to overdose and death. It can also cause life-threatening breathing problems, especially when starting or increasing the dose. Accidental ingestion, even one dose, can cause a fatal overdose, especially in children. Taking Percocet with benzodiazepines or other CNS depressants, including alcohol, can cause severe sedation, breathing problems, coma, and death. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn. Acetaminophen can cause liver damage if you take too much.

Known Drug Interactions

moderate gabapentin

Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.

Mechanism: Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.

moderate pregabalin

Mechanism: Both drugs slow down the central nervous system. Using them together can cause extreme sleepiness and make it hard to breathe.

minor trazodone

Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tryptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and...

Mechanism: Both drugs increase a brain chemical called serotonin, which can lead to a rare but serious reaction.

minor tramadol

Mechanism: Using these two drugs together can cause too much serotonin to build up in your body.

minor cyclobenzaprine

Mechanism: Both drugs increase serotonin levels in the brain, which can cause a serious reaction called serotonin syndrome.

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This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I drive while taking Percocet?

Percocet can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you.

Can I drink alcohol while taking Percocet?

No, drinking alcohol while taking Percocet can cause dangerous side effects, including slowed breathing, coma, and death.

What should I do if I overdose on Percocet?

Seek emergency medical help immediately. An overdose can cause slowed or stopped breathing, liver damage, coma, and death.

Can I take other medicines with Percocet?

Talk to your doctor or pharmacist before taking any other medicines with Percocet. Some medicines can interact and cause dangerous side effects.

How do I know if I am becoming addicted to Percocet?

If you feel like you need to take more Percocet than prescribed, or if you are having trouble stopping it, talk to your doctor right away.

What are the signs of respiratory depression?

Signs of respiratory depression include slow or shallow breathing, confusion, and bluish skin.

Can I crush or chew Percocet tablets?

No, swallow Percocet tablets whole. Crushing or chewing them can release too much medicine at once, which can be dangerous.

What should I tell my doctor before taking Percocet?

Tell your doctor about all your medical conditions, including any breathing problems, liver or kidney disease, or history of drug or alcohol abuse.

How often can I take Percocet?

Take Percocet exactly as prescribed by your doctor. Do not take it more often or for a longer period than prescribed.

What is a REMS program?

REMS stands for Risk Evaluation and Mitigation Strategy. It is a program to help ensure the safe use of opioid pain medicines.

What are the common side effects of acetaminophen/oxycodone?

The registry lists Lightheadedness, Dizziness, Drowsiness, Nausea, Vomiting among the most-reported FAERS reaction terms for acetaminophen/oxycodone. The compiled record contains 247,238 FDA adverse-event reports. These counts are not an individual symptom assessment.

Does acetaminophen/oxycodone interact with other medications?

The registry has 23 documented interaction rows for acetaminophen/oxycodone. Notable source-record pairings include gabapentin, pregabalin, trazodone. These rows are not a complete medication review.

What drug class is acetaminophen/oxycodone?

acetaminophen/oxycodone belongs to the Opioid Analgesic Combination drug class. It requires a prescription (Rx). Percocet is used to manage severe pain.

What pregnancy or breastfeeding source fields are listed for acetaminophen/oxycodone?

The FDA label for acetaminophen/oxycodone contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

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