Prescription medication · Fluoroquinolone Antibiotic
ciprofloxacin
Also sold as Cipro. These eye drops treat corneal ulcers and conjunctivitis (pink eye) caused by certain bacteria.
Data updated 2026-05-15
- 89,398
- FDA reportsOften reported
- 14
- InteractionsSeveral interactions
- 25% less
- Generic vs brandReal savings
- 4
- Recall records
What the data shows
ciprofloxacin (Cipro) is a prescription Fluoroquinolone Antibiotic, more reported than most tracked drugs (89,398 FDA reports), with a lower-cost generic available (25% less than brand).
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
ciprofloxacin (Cipro) is a prescription Fluoroquinolone Antibiotic. These eye drops treat corneal ulcers and conjunctivitis (pink eye) caused by certain bacteria.
Ciprofloxacin eye drops are an antibiotic medicine. They treat bacterial infections in the eye.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$1.46/unit
Generic Price
$1.10/unit
Generic Savings
25%
Generic Available
Yes (21 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
These eye drops treat corneal ulcers and conjunctivitis (pink eye) caused by certain bacteria.
Common side effects
Burning or discomfort in the eye, White crystal-like build-up in the eye
Key warnings
Do not inject this medicine into your eye.
The sections below are summarized in plain English from ciprofloxacin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Ciprofloxacin is a fluoroquinolone antibiotic. It stops bacteria from growing and multiplying. This helps your body fight off the infection.
Side Effects (from patient reports)
Based on 89,398 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for ciprofloxacin, by number of reports
- Drug Hypersensitivity
Drug Hypersensitivity
5,673 reports
- Pain
Pain
5,587 reports
- Fatigue
Fatigue
5,503 reports
- Diarrhoea
Diarrhoea
5,326 reports
- Nausea
Nausea
5,298 reports
- Arthralgia
Arthralgia
5,211 reports
- Acute Kidney Injury
Acute Kidney Injury
4,502 reports
- Chronic Kidney Disease
Chronic Kidney Disease
4,395 reports
- Dyspnoea
Dyspnoea
4,098 reports
- Pyrexia
Pyrexia
3,886 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for ciprofloxacin each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where ciprofloxacin sits
ciprofloxacin has more FDA adverse-event reports than 84% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is ciprofloxacin; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 89,398 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 1997–2025.
Total Reports
89,398
Reports Mentioning Death
9,101
10.2% of reports — not proof of cause
Hospitalization Reports
34,823
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DRUG HYPERSENSITIVITY | 5,673 |
| 2 | PAIN | 5,587 |
| 3 | FATIGUE | 5,503 |
| 4 | DIARRHOEA | 5,326 |
| 5 | NAUSEA | 5,298 |
| 6 | ARTHRALGIA | 5,211 |
| 8 | ACUTE KIDNEY INJURY | 4,502 |
| 9 | CHRONIC KIDNEY DISEASE | 4,395 |
| 10 | DYSPNOEA | 4,098 |
| 12 | PYREXIA | 3,886 |
| 13 | ANXIETY | 3,810 |
| 14 | VOMITING | 3,723 |
| 15 | HEADACHE | 3,680 |
| 16 | PAIN IN EXTREMITY | 3,591 |
| 17 | DIZZINESS | 3,285 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Do not inject this medicine into your eye. Some people have had very bad allergic reactions, even after the first dose. Get emergency help right away if you have trouble breathing, pass out, or have swelling of the face, throat, or tongue.
Known Drug Interactions
( 7.2 , 12.3 ) 7.1 Strong CYP1A2 Inhibitors Concomitant use of tizanidine with strong cytochrome P450 1A2 (CYP1A2) inhibitors (e.g., fluvoxamine, ciprofloxacin) is contraindicated.
Mechanism: Ciprofloxacin stops the body from breaking down tizanidine. This can cause tizanidine to build up to dangerous levels in your system.
However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Mechanism: Taking these two drugs together can cause a temporary increase in creatinine levels, which is a sign of stress on the kidneys.
However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Mechanism: Ciprofloxacin makes it harder for your body to clear theophylline. This results in higher than normal levels of theophylline in your blood.
Drugs that have been shown, or would be expected, to increase plasma carbamazepine levels include aprepitant, cimetidine, ciprofloxacin, danazol, diltiazem, macrolides (e.g., erythromycin, clarithromycin), fluoxetine, fluvoxamine, trazodone, omeprazole, oxybutynin, isoniazid, niacinamide (nicotinamide), azoles (e.g., ketaconazole, itraconazole, fluconazole, voriconazole), acetazolamide, verapamil, ticlopidine, grapefruit juice, and protease inhibitors.
Mechanism: Ciprofloxacin slows down how your body gets rid of carbamazepine, which can cause the drug to build up to high levels.
7 DRUG INTERACTIONS Concomitant use of Strong CYP1A2 Inhibitors : Reduce VERSACLOZ dose to one third when coadministered with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, enoxacin) ( 2.7 , 7.1 ). Reduce the VERSACLOZ dose to one third of the original dose when VERSACLOZ is coadministered with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin, or enoxacin).
Mechanism: Ciprofloxacin is a strong blocker of the enzyme that clears clozapine, which can cause clozapine levels to become very high.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I use these eye drops with my contact lenses?
What if I am using other eye drops?
How long should I use these drops?
What should I do if the drops make my vision blurry?
Can I touch the dropper tip to my eye?
What if I accidentally swallow some of the eye drops?
Can I share these eye drops with someone else?
How will I know if the drops are working?
What do I do if I get a lot of burning when I use the drops?
How do I keep the eye drops clean?
What are the common side effects of ciprofloxacin?
Does ciprofloxacin interact with other medications?
What drug class is ciprofloxacin?
Is there a generic version of ciprofloxacin?
What pregnancy or breastfeeding source fields are listed for ciprofloxacin?
Has ciprofloxacin been recalled?
Active Recalls
Temperature Abuse
Sandoz Inc
Defective container: Unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle
FDC Limited
Defective Container: Unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle
Direct Rx
Defective container: Unable to get the solution out of the bottle as the spike of the cap was lodged in the nozzle of the product bottle
FDC Limited
Related Medications in Fluoroquinolone Antibiotic
Other drugs grouped near ciprofloxacin - same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with ciprofloxacin →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with ciprofloxacin →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with ciprofloxacin →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with ciprofloxacin →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with ciprofloxacin →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for ciprofloxacin: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 89,398.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 10.18%.
- trazodone Δ 0.00 pts · 15,113 reports · Serotonin Antagonist and Reuptake Inhibitor (SARI) 10.18%death share
- lubiprostone Δ 0.00 pts · 9,102 reports · Chloride Channel Activator 10.18%death share
- sertraline Δ 0.01 pts · 112,198 reports · Selective Serotonin Reuptake Inhibitor (SSRI) 10.19%death share
- pioglitazone Δ 0.07 pts · 42,504 reports · Thiazolidinedione 10.11%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Save on ciprofloxacin
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What the FDA Data Shows for ciprofloxacin
The FDA label for ciprofloxacin (sold under brand names such as Cipro) classifies it as a prescription-only medication in the Fluoroquinolone Antibiotic class. These eye drops treat corneal ulcers and conjunctivitis (pink eye) caused by certain bacteria. Official labeling lists 2 commonly reported side effects, including Burning or discomfort in the eye, White crystal-like build-up in the eye.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 89,398 voluntary reports. The database also lists 14 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $1.10 versus $1.46 for the brand - a 25% generic savings.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 4 recall records on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: May 2, 2022
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages