isradipine

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Mechanism: This medication does not affect the speed at which your body breaks down theophylline or clears it from your blood.

What to do: You can take these two medicines together without needing to change your theophylline dose, though close monitoring is always recommended.

Hydrochlorothiazide: A study in normal healthy volunteers has shown that concomitant administration of isradipine and hydrochlorothiazide does not result in altered pharmacokinetics of either drug. In a study in hypertensive patients, addition of isradipine to existing hydrochlorothiazide therapy did not result in any unexpected adverse effects, and isradipine had an additional antihypertensive effect.

Mechanism: These medicines work in different ways to lower blood pressure, which can lead to a stronger effect when taken together.

What to do: Your doctor may use this combination to better control your blood pressure, but you should report any dizziness or lightheadedness.

Propranolol: In a single dose study in normal volunteers, co-administration of propranolol had a small effect on the rate but no effect on the extent of isradipine bioavailability. Significant increases in AUC (27%) and C max (58%) and decreases in t max (23%) of propranolol were noted in this study. propranolol to healthy volunteers under steady-state conditions had no relevant effect on either drug's bioavailability.

Mechanism: Taking these drugs together may temporarily change how much medicine is in your blood, but this effect usually disappears after a few days of regular use.

What to do: Your doctor may monitor your heart rate and blood pressure more closely when you first start taking these two drugs together.

Warfarin: In a study in healthy volunteers, no clinically relevant pharmacokinetic or pharmacodynamic interaction between isradipine and racemic warfarin was seen when two single oral doses of warfarin (0.7 mg/kg body weight) were administered during 11 days of multiple-dose treatment with 5 mg b.i.d. Neither racemic warfarin nor isradipine binding to plasma proteins in vitro was altered by the addition of the other drug.

Mechanism: These two drugs do not appear to change how the body handles or responds to either medication.

What to do: No special changes are usually needed, but you should continue your regular blood tests for monitoring your blood thinner.

Digoxin: The concomitant administration of isradipine and digoxin in a single-dose pharmacokinetic study did not affect renal, nonrenal and total body clearance of digoxin.

Mechanism: Isradipine does not change how your body removes digoxin from your system.

What to do: You can usually take these together without changing your dose, but your doctor will continue to monitor your heart health.