Prescription medicine
Isradipine First approved as Dynacirc
Isradipine (Dynacirc) is a prescription medicine with an FDA approval on record since 1990. FDA's NDC Directory lists it from 3 generic labelers, and pharmacies paid $1.70 per isradipine 5 mg capsule in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the isradipine FDA label on DailyMed (effective November 30, 2023, Teva Pharmaceuticals USA, Inc.); the NDA 19546 record on Drugs@FDA; every isradipine label on DailyMed.
Highlights of the record
FDA label of November 30, 2023; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageHypertension Isradipine is indicated in the management of hypertension.
Forms and strengths
- 2.5 mg
- 5 mg
Capsule.
On the market
- Earliest approval on file
- December 20, 1990 Dynacirc, Smithkline Beecham; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 3 first January 5, 2006; 2 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 3 of which 3 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $1.70 per capsule Isradipine 5 mg capsule
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 554 through July 30, 2026
What is isradipine used for?
From the label: indications and usageHypertension Isradipine is indicated in the management of hypertension. It may be used alone or concurrently with thiazide-type diuretics.
Conditions named in the indications of isradipine's FDA labels, with every medicine labeled for each:
From other isradipine labelsHigh blood pressure: INDICATIONS AND USAGE Hypertension Isradipine is indicated in the management of hypertension.
FDA pharmacologic class: Dihydropyridine Calcium Channel Blocker.
Source: FDA drug label (Isradipine), Teva Pharmaceuticals USA, Inc., effective November 30, 2023 (SPL set bf3425e0-428d-4bdb-ac9a-3b9d483df83a), via openFDA; the full label on DailyMed
Is there a generic for isradipine (Dynacirc)?
The FDA approved the first generic isradipine on January 5, 2006. 3 generic applications are approved; 2 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists isradipine from 3 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1990 earliest approval on file
- 2006 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for isradipine (Dynacirc)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $1.70 per Isradipine 5 mg capsule, down 24% from $2.25 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Isradipine 2.5 mg capsule (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Isradipine 2.5 mg capsule | Generic | $1.14 per capsule | $34.10 | n/a |
| Isradipine 5 mg capsule | Generic | $1.70 per capsule | $51.07 | -24% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the isradipine label say about other medicines?
The isradipine label names 7 other medicines in its interaction, contraindication or warning sections. The labels of 5 other medicines name isradipine. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Cimetidine | drug interactions | In a study in healthy volunteers, a one-week course of cimetidine at 400 mg b.i.d. with a single 5 mg dose of isradipine on the sixth day showed an increase in isradipine mean peak plasma concentrations (36%) and significant increase in area under the curve (50%). |
| Digoxin | drug interactions | The concomitant administration of isradipine and digoxin in a single-dose pharmacokinetic study did not affect renal, nonrenal and total body clearance of digoxin. |
| Fentanyl | drug interactions | Fentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker. |
| Hydrochlorothiazide | drug interactions | Hydrochlorothiazide: A study in normal healthy volunteers has shown that concomitant administration of isradipine and hydrochlorothiazide does not result in altered pharmacokinetics of either drug. |
| Nitroglycerin | drug interactions | Drug Interactions Nitroglycerin: Isradipine has been safely coadministered with nitroglycerin. |
| Propranolol | drug interactions | Significant increases in AUC (27%) and C max (58%) and decreases in t max (23%) of propranolol were noted in this study. |
| Warfarin | drug interactions | In a study in healthy volunteers, no clinically relevant pharmacokinetic or pharmacodynamic interaction between isradipine and racemic warfarin was seen when two single oral doses of warfarin (0.7 mg/kg body weight) were administered during 11 days of multiple-dose treatment with 5 mg b.i.d. isradipine. |
Other labels that name isradipine
Source: FDA drug label (Isradipine), Teva Pharmaceuticals USA, Inc., effective November 30, 2023 (SPL set bf3425e0-428d-4bdb-ac9a-3b9d483df83a), via openFDA; the full label on DailyMed
What do FAERS reports show for isradipine?
The FDA Adverse Event Reporting System holds 554 reports that list isradipine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 65 are coded as a death and 298 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as isradipine?
72 other medicines are given the same way (oral) and in the same FDA class as isradipine or labeled mainly for the same use (high blood pressure), the same class first. High blood pressure lists all 88 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Amlodipine | High blood pressure | 42 labelers | $0.0102 per tablet 5 mg tablet | No current entry |
| Nifedipine | High blood pressure | 32 labelers | $0.130 per tablet 30 mg tablet | No current entry |
| Amlodipine and benazepril | High blood pressure | 16 labelers | $0.114 per unit 10-20 mg | No current entry |
| Amlodipine and atorvastatin | High blood pressure | 6 labelers | $1.34 per unit 10-40 mg | No current entry |
| Amlodipine and olmesartan | High blood pressure | 14 labelers | $0.248 per unit 10-20 mg | No current entry |
| Felodipine | High blood pressure | 14 labelers | $0.123 per tablet 5 mg tablet | No current entry |
| Amlodipine and hydrochlorothiazide and olmesartan | High blood pressure | 8 labelers | $0.776 per unit 20-5-12.5 | No current entry |
| Amlodipine and valsartan | High blood pressure | 9 labelers | $0.330 per unit 10-160 mg | No current entry |
Every medicine labeled for the same conditions as isradipine
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does isradipine compare with medicines for the same use?
1 side-by-side page set isradipine beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to isradipine
- 72 medicines for the same use
- Other calcium channel blockers
- the pharmacologic class, with prices and generics
- Isradipine side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other