insulin aspart
Brand names: NovoLog, Fiasp
NovoLog (insulin aspart) is a rapid-acting insulin that helps control blood sugar in people with diabetes. It works quickly to lower blood sugar levels after meals.
Drug Pricing (NADAC)
Brand Price
$35.76/unit
Generic Price
$6.95/unit
Generic Savings
81%
Generic Available
Yes (0 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
NovoLog is used to improve blood sugar control in adults and children with diabetes.
Common side effects
Headache, Accidental injury, Nausea
Key warnings
Never share your NovoLog FlexPen, FlexTouch, PenFill cartridge, or PenFill cartridge device with anyone else, even if the needle is changed.
How It Works
NovoLog is a man-made form of insulin that works like the insulin your body naturally makes. It helps sugar (glucose) move from your blood into your cells, where it can be used for energy. This lowers the amount of sugar in your blood.
How to Take It
Inject NovoLog under your skin 5 to 10 minutes before you eat a meal. You can inject it into your belly area, thigh, buttocks, or upper arm. Change your injection site each time to avoid skin problems. You may also use an insulin pump to administer NovoLog.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. Good control of diabetes is important during pregnancy for both you and your baby. Discuss the best way to manage your blood sugar with your doctor.
Missed Dose
If you miss a dose of NovoLog, take your next dose as soon as you remember and then continue with your regular schedule. However, do not take a double dose to make up for a missed dose.
Storage
Store NovoLog in the refrigerator until you are ready to use it. Do not freeze. Keep away from heat and light.
Side Effects (from patient reports)
Based on 34,906 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 63,536 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
63,536
Death-Related Reports
4,425
Hospitalization Reports
20,996
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | BLOOD GLUCOSE INCREASED | 10,424 |
| 2 | NAUSEA | 3,724 |
| 3 | BLOOD GLUCOSE DECREASED | 3,344 |
| 4 | DRUG INEFFECTIVE | 3,286 |
| 5 | FATIGUE | 2,664 |
| 6 | DYSPNOEA | 2,553 |
| 7 | DIARRHOEA | 2,542 |
| 8 | VOMITING | 2,387 |
| 9 | DIZZINESS | 2,013 |
| 10 | OFF LABEL USE | 1,971 |
| 11 | WEIGHT DECREASED | 1,843 |
| 12 | FALL | 1,828 |
| 13 | HEADACHE | 1,813 |
| 14 | MALAISE | 1,789 |
| 15 | PAIN | 1,768 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Never share your NovoLog FlexPen, FlexTouch, PenFill cartridge, or PenFill cartridge device with anyone else, even if the needle is changed. Sharing insulin pens or cartridges can spread blood-borne diseases. Changes in your insulin regimen should be made carefully under medical supervision. Low blood sugar can be life-threatening. Monitor your blood sugar regularly. Fluid retention and heart failure can occur if you take NovoLog with thiazolidinediones (TZDs).
Known Drug Interactions
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. • Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulf...
Mechanism: Fluoxetine can make insulin work more strongly, which may cause your blood sugar to drop to a level that is too low.
What to do: Monitor your blood sugar levels closely if you take both of these medications. Your doctor may need to adjust your insulin dose.
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. • Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulf...
Mechanism: Both of these medications are used to lower blood sugar, so taking them together increases the chance of your blood sugar falling to a dangerous level.
What to do: Watch for signs of low blood sugar and check your levels often. Your healthcare provider might need to change your insulin dosage.
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. • Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulf...
Mechanism: Octreotide can change how your body handles sugar and may increase the blood-sugar-lowering effects of insulin.
What to do: Be sure to monitor your blood sugar frequently while using these drugs together. Your doctor may need to lower your insulin dose to keep you safe.
Drugs That May Decrease the Blood Glucose Lowering Effect of NOVOLOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. • Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptive...
Mechanism: Albuterol can make insulin less effective at lowering your blood sugar. This means your blood sugar levels might stay higher than they should while using this medication.
What to do: You should monitor your blood sugar levels more closely when taking these drugs together to ensure they stay in a healthy range.
Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of NOVOLOG Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine and reserpine Intervention: Increased frequency of glucose monitoring may be required when NOVOLOG is concomitantly administered with these drugs. • Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine ( 7 ).
Mechanism: Clonidine can cause your blood sugar to either rise or fall and may also hide the physical warning signs of low blood sugar. This makes it harder to tell if your blood sugar is dropping to a dangerous level.
What to do: You should check your blood sugar more often and talk to your doctor about how to stay safe if you cannot feel the symptoms of low blood sugar.
Common Questions
What should I do if my blood sugar is too high?
Can I mix NovoLog with other insulins?
What are the symptoms of low blood sugar?
How often should I check my blood sugar?
What should I do if I have an allergic reaction to NovoLog?
Can other medications affect NovoLog?
What if my pump malfunctions?
Can I use NovoLog if I have kidney or liver problems?
What if I change my injection site?
What happens if I repeatedly inject into the same area?
What are the common side effects of insulin aspart?
Does insulin aspart interact with other medications?
What drug class is insulin aspart?
Is there a generic version of insulin aspart?
Is insulin aspart safe during pregnancy?
Related Medications in Rapid-Acting Insulin
Other drugs grouped near insulin aspart — same-class peers and common alternatives.
acarbose
Precose
Acarbose is a medicine that helps lower blood sugar levels in people with type 2 diabetes.
Compare with insulin aspart →
alogliptin
Nesina
Alogliptin and Metformin HCl is a drug that helps lower blood sugar in adults with type 2 diabetes.
Compare with insulin aspart →
bromocriptine
Cycloset
Bromocriptine (Cycloset) is a medicine that acts like dopamine in your body.
Compare with insulin aspart →
canagliflozin
Invokana
Invokana is a medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes.
Compare with insulin aspart →
colesevelam
Welchol
Colesevelam is a medicine that helps lower bad cholesterol (LDL-C) and control blood sugar in adults.
Compare with insulin aspart →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Related Health & Safety Data
🩺 Find a Doctor
Search prescribers for Rapid-Acting Insulin
🏨 Hospital Quality
CMS hospital ratings, safety scores & patient outcomes
💊 Supplement Data
NIH DSLD — check supplement ingredients & label claims
🍽️ Food Safety Alerts
FDA recalls, inspections & outbreak investigations
⚠️ Product Recalls
FDA, CPSC & NHTSA recall search
💉 Procedure Costs
Medicare procedure pricing for 9,297 procedures
Save on insulin aspart
Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.
Disclosure: This link may earn us a commission at no extra cost to you. See our terms.
What the FDA Data Shows for insulin aspart
The FDA label for insulin aspart (sold under brand names such as NovoLog, Fiasp) classifies it as a prescription-only medication in the Rapid-Acting Insulin class. NovoLog is used to improve blood sugar control in adults and children with diabetes. Official labeling lists 10 commonly reported side effects, including Headache, Accidental injury, Nausea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 34,906 voluntary reports. The database also lists 11 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $6.95 versus $35.76 for the brand — a 81% generic savings.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: December 15, 2023
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages