insulin lispro
Brand names: Humalog
Admelog is a rapid-acting insulin that helps control blood sugar levels. It is used to treat diabetes in adults and children.
Drug Pricing (NADAC)
Brand Price
$9.80/unit
Generic Price
$10.20/unit
Generic Available
Yes (0 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Admelog is used to improve blood sugar control in people with diabetes.
Common side effects
Common cold, Upper respiratory infection
Key warnings
Never share your Admelog SoloStar pen or syringe with anyone else, even if you change the needle.
How It Works
Admelog is a man-made insulin that works like the insulin your body should be making. It helps sugar move from your blood into your cells. This lowers your blood sugar levels.
How to Take It
Admelog is injected under the skin within 15 minutes before or right after you eat a meal. You can inject it into your belly area, thigh, upper arm, or buttocks. Change your injection spot each time to avoid skin problems. Your doctor will tell you how much Admelog to use based on your needs.
Pregnancy & Breastfeeding
Talk to your doctor if you are pregnant or plan to become pregnant. Poorly controlled diabetes during pregnancy can harm both the mother and the baby. Discuss the risks and benefits of using Admelog with your doctor if you are breastfeeding.
Missed Dose
If you miss a dose, check your blood sugar and take your next dose as usual with your next meal. Do not take a double dose to make up for the missed one.
Storage
Keep unopened Admelog in the refrigerator or at room temperature for up to 28 days. Once opened, keep at room temperature and throw away after 28 days, even if there is medicine left.
Side Effects (from patient reports)
Based on 89,504 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 134,198 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
134,198
Death-Related Reports
5,906
Hospitalization Reports
33,389
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | BLOOD GLUCOSE INCREASED | 38,180 |
| 2 | INCORRECT DOSE ADMINISTERED | 9,067 |
| 3 | BLOOD GLUCOSE DECREASED | 8,761 |
| 4 | DRUG INEFFECTIVE | 8,068 |
| 5 | VISUAL IMPAIRMENT | 5,392 |
| 6 | NAUSEA | 4,787 |
| 7 | MALAISE | 3,946 |
| 8 | HYPOGLYCAEMIA | 3,800 |
| 9 | FATIGUE | 3,754 |
| 10 | DRUG DOSE OMISSION | 3,751 |
| 11 | FALL | 3,428 |
| 12 | UNDERDOSE | 3,374 |
| 13 | DIARRHOEA | 3,156 |
| 14 | GLYCOSYLATED HAEMOGLOBIN INCREASED | 3,144 |
| 15 | VOMITING | 3,121 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Never share your Admelog SoloStar pen or syringe with anyone else, even if you change the needle. Sharing can spread blood-borne diseases. Changes in your insulin plan can cause high or low blood sugar. Make these changes carefully with your doctor's help. Low blood sugar can be life-threatening. Watch your blood sugar closely.
Known Drug Interactions
Table 2: Clinically Significant Drug Interactions with ADMELOG Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide,...
Mechanism: Fluoxetine can increase the blood-sugar-lowering effect of insulin, which raises the risk of your blood sugar dropping too low.
What to do: Monitor your blood sugar levels closely and talk to your doctor about adjusting your insulin dose.
Table 2: Clinically Significant Drug Interactions with ADMELOG Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide,...
Mechanism: Both of these medicines lower blood sugar, so taking them together increases the chance of having dangerously low blood sugar.
What to do: You should check your blood sugar more frequently and your doctor may need to adjust your insulin dosage.
Table 2: Clinically Significant Drug Interactions with ADMELOG Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide,...
Mechanism: Octreotide can make insulin work more strongly or lower blood sugar on its own, which increases the risk of hypoglycemia.
What to do: Watch for signs of low blood sugar and consult your doctor about potential changes to your insulin dose.
Drugs That May Decrease the Blood Glucose Lowering Effect of ADMELOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives,...
Mechanism: Albuterol can make insulin less effective at lowering your blood sugar levels.
What to do: Check your blood sugar levels often and consult your doctor about adjusting your insulin dose.
Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of ADMELOG Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine and reserpine. Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine ( 7 ).
Mechanism: Clonidine can change how insulin affects your blood sugar and may hide the physical signs of low blood sugar.
What to do: Monitor your blood sugar levels closely and be aware that you might not notice typical symptoms of low blood sugar.
Common Questions
What should I do if my insulin pump malfunctions?
Can I mix Admelog with other insulins?
How often should I change the Admelog in my insulin pump?
What if I see particles or color in my Admelog?
Can changes to my insulin plan affect my blood sugar?
What should I do if I keep injecting into the same spot?
How often should I check my blood sugar?
What happens if I take too much Admelog?
What happens if I don't take enough Admelog?
Can other medicines affect Admelog?
What are the common side effects of insulin lispro?
Does insulin lispro interact with other medications?
What drug class is insulin lispro?
Is insulin lispro safe during pregnancy?
Has insulin lispro been recalled?
Active Recalls
Lack of Assurance of Sterility: Malformed crimped collar seal
Sanofi-Aventis U.S. LLC
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What the FDA Data Shows for insulin lispro
The FDA label for insulin lispro (sold under brand names such as Humalog) classifies it as a prescription-only medication in the Rapid-Acting Insulin class. Admelog is used to improve blood sugar control in people with diabetes. Official labeling lists 2 commonly reported side effects, including Common cold, Upper respiratory infection.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 89,504 voluntary reports. The database also lists 11 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $10.20 versus $9.80 for the brand.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: June 4, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages