linagliptin
Brand names: Tradjenta
Jentadueto XR is a drug that combines linagliptin and metformin. It helps lower blood sugar in adults with type 2 diabetes, along with diet and exercise.
Drug Pricing (NADAC)
Brand Price
$16.77/unit
Generic Available
Yes (2 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Jentadueto XR is used to improve blood sugar control in adults with type 2 diabetes.
Common side effects
Runny nose or sore throat, Diarrhea
Key warnings
Jentadueto XR can cause a serious side effect called lactic acidosis.
How It Works
This medicine contains two drugs. Linagliptin helps your body release more insulin after you eat. Metformin helps your body use insulin better and reduces sugar production in the liver.
How to Take It
Take Jentadueto XR one time each day with a meal. Swallow the tablets whole; do not crush, split, or chew them. Your doctor will adjust your dose based on how well the medicine works for you. Make sure to have your kidney function checked before starting and while taking this medicine.
Pregnancy & Breastfeeding
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if Jentadueto XR will harm your unborn baby. Discuss the best way to control your blood sugar during pregnancy with your doctor.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.
Storage
Store Jentadueto XR at room temperature, away from moisture.
Side Effects (from patient reports)
Based on 9,962 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 17,378 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2006–2025.
Total Reports
17,378
Death-Related Reports
1,613
Hospitalization Reports
6,542
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | BLOOD GLUCOSE INCREASED | 1,326 |
| 2 | DIARRHOEA | 1,196 |
| 3 | NAUSEA | 1,138 |
| 4 | FATIGUE | 1,028 |
| 5 | DYSPNOEA | 998 |
| 6 | OFF LABEL USE | 921 |
| 7 | DIZZINESS | 919 |
| 8 | VOMITING | 875 |
| 9 | MALAISE | 789 |
| 10 | ACUTE KIDNEY INJURY | 772 |
| 11 | HEADACHE | 745 |
| 12 | ARTHRALGIA | 723 |
| 13 | PRURITUS | 720 |
| 14 | PYREXIA | 687 |
| 15 | DRUG INEFFECTIVE | 642 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Jentadueto XR can cause a serious side effect called lactic acidosis. This is a buildup of lactic acid in your blood. Get medical help right away if you have symptoms like weakness, muscle pain, trouble breathing, stomach pain, dizziness, or a slow or irregular heartbeat. Certain conditions increase your risk, such as kidney problems, drinking a lot of alcohol, or having surgery.
Known Drug Interactions
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] . Alcohol Clinical Impact Alcohol is known to potentiate the effect of metformin on lactate metabolism. ( 7 ) Drugs that Reduce...
Mechanism: One drug may slow down how fast the other is removed from your body through your kidneys. This can cause a dangerous buildup of medicine and lead to a serious condition called lactic acidosis.
What to do: Your doctor may need to monitor your kidney function and adjust your dosages. Seek medical care if you experience unusual muscle pain, trouble breathing, or extreme weakness.
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Mechanism: Dolutegravir prevents your kidneys from removing metformin from your body. This can cause the drug to build up and increase the risk of a serious condition called lactic acidosis.
What to do: Your doctor may need to adjust your dose or monitor you more closely. Tell your doctor if you feel very weak, dizzy, or have trouble breathing.
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Mechanism: Ranolazine stops your kidneys from getting rid of metformin properly. This can lead to a buildup of the drug, which increases the risk of a serious side effect called lactic acidosis.
What to do: Talk to your doctor about monitoring your blood levels or adjusting your dose. Seek medical help if you feel very weak, tired, or have stomach pain.
Drugs that Reduce Metformin Clearance Clinical Impact Concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) could increase systemic exposure to metformin and may increase the risk for lactic acidosis [see Clinical Pharmacology (12.3) ] .
Mechanism: Cimetidine makes it harder for your kidneys to filter metformin out of your system. This can cause metformin levels to rise, which may lead to a dangerous buildup of acid in your blood.
What to do: Your healthcare provider may need to adjust your dose or monitor you more frequently. Let your doctor know if you experience unusual tiredness or muscle aches.
Table 2 Clinically Relevant Interactions with JENTADUETO XR Carbonic Anhydrase Inhibitors Clinical Impact Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.
Mechanism: Topiramate can lower the level of bicarbonate in your blood, which makes your blood more acidic. This increases the risk of a serious condition called metabolic acidosis when taken with this diabetes medication.
What to do: Your doctor should monitor your blood chemistry and may need to adjust your treatment if you show signs of high acid levels.
Common Questions
Can I take Jentadueto XR if I have kidney problems?
What should I do if I experience stomach upset while taking this medicine?
Can Jentadueto XR cause low blood sugar?
Can I drink alcohol while taking Jentadueto XR?
What are the symptoms of lactic acidosis?
Does Jentadueto XR interact with other medications?
What should I do if I need to have an X-ray or CT scan with contrast dye?
Can Jentadueto XR cause heart problems?
What if I develop blisters while taking Jentadueto XR?
How often will my doctor check my vitamin B12 levels?
What are the common side effects of linagliptin?
Does linagliptin interact with other medications?
What drug class is linagliptin?
Is linagliptin safe during pregnancy?
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What the FDA Data Shows for linagliptin
The FDA label for linagliptin (sold under brand names such as Tradjenta) classifies it as a prescription-only medication in the DPP-4 Inhibitor class. Jentadueto XR is used to improve blood sugar control in adults with type 2 diabetes. Official labeling lists 2 commonly reported side effects, including Runny nose or sore throat, Diarrhea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 9,962 voluntary reports. The database also lists 9 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: May 24, 2024
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages