ketoprofen

Probenecid Probenecid increases both free and bound ketoprofen by reducing the plasma clearance of ketoprofen to about one-third, as well as decreasing its protein binding. Therefore, the combination of ketoprofen and probenecid is not recommended.

Mechanism: Probenecid slows down how quickly the body clears ketoprofen, leading to higher levels of the drug in the blood.

What to do: This combination is not recommended and should be avoided.

Table 3: Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Non-steroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafa...

Mechanism: Ketoprofen is an anti-inflammatory drug that adds to the blood-thinning effect of warfarin. This combination makes it more likely for you to experience bleeding or bruising.

What to do: Watch for unusual bruising or bleeding and report it to your doctor. Your blood levels may need to be checked more frequently.

Hydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone.

Mechanism: Ketoprofen can change how your kidneys handle salt and minerals when you are also taking this water pill. This can reduce the amount of potassium and chloride you pass in your urine.

What to do: Your doctor may want to monitor your kidney function and mineral levels through regular blood tests.

Diuretics NSAIDs can reduce the natriuetic effect of furosemide and thiazides in some patients.

Mechanism: Ketoprofen can stop furosemide from working as well to remove salt and water from your body. This happens because the pain reliever interferes with the way the water pill affects your kidneys.

What to do: Your doctor may need to check your blood pressure or fluid levels more often. They might adjust your dose if the water pill is not working correctly.

Aspirin Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin. The clinical significance of these changes is not known; however, as with other NSAIDs, concomitant administration of ketoprofen and aspirin is not generally recommended because of the potential of increased adverse effects.

Mechanism: Aspirin makes ketoprofen leave your body faster and changes how it travels in your blood. Taking both at the same time can also increase your risk of having bad side effects.

What to do: You should generally avoid taking these two medicines together. Talk to your doctor about safer ways to manage your pain.