clomiphene
Brand names: Clomid, Serophene
Clomiphene citrate is a medicine that helps women ovulate. It is used to help women get pregnant.
Drug Pricing (NADAC)
Generic Price
$7.55/unit
Generic Available
Yes (6 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Clomiphene citrate is used to treat women who have problems with ovulation and want to get pregnant.
Common side effects
Ovarian enlargement, Hot flashes, Abdominal or pelvic discomfort, bloating
Key warnings
Clomiphene citrate can cause ovarian hyperstimulation syndrome (OHSS).
How It Works
This medicine works by affecting estrogen levels in your body. It makes your body release hormones that cause your ovaries to release an egg. This can help you get pregnant.
How to Take It
Take clomiphene citrate exactly as your doctor tells you. Usually, you will take one 50 mg tablet daily for 5 days. Start on or around the 5th day of your menstrual cycle. Have sex around the time you expect to ovulate. Your doctor may adjust your dose based on how you respond.
Pregnancy & Breastfeeding
You should not take clomiphene citrate if you are pregnant. It can cause problems with the baby's development. Talk to your doctor if you become pregnant while taking this medicine.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Storage
Store tablets at room temperature (59° to 86°F). Keep away from heat, light, and moisture.
Side Effects (from patient reports)
Based on 770 FDA adverse event reports.
Serious Warnings
Clomiphene citrate can cause ovarian hyperstimulation syndrome (OHSS). This is a serious condition where your ovaries get too large and fluid builds up in your body. Call your doctor right away if you have severe pelvic pain, nausea, vomiting, weight gain, or trouble breathing.
Common Questions
How long can I take clomiphene citrate?
What if I don't ovulate after the first course?
Can clomiphene citrate cause twins?
What tests will I need while taking this medicine?
When should I have sex while taking clomiphene citrate?
What if I don't get pregnant after taking clomiphene citrate?
Can clomiphene citrate cause mood changes?
What should I do if I have blurry vision?
Can I take clomiphene citrate if I have liver problems?
Can I take clomiphene citrate if I have ovarian cysts?
What are the common side effects of clomiphene?
What drug class is clomiphene?
Is clomiphene safe during pregnancy?
Related Medications in Selective Estrogen Receptor Modulator (Fertility)
Other drugs grouped near clomiphene — same-class peers and common alternatives.
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anastrozole
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Anastrozole is a medicine used to treat breast cancer in women after menopause.
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bazedoxifene/conjugated estrogens
Duavee
Duavee is a combination medicine containing estrogen and a drug that blocks estrogen in some parts of the body.
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cabergoline
Dostinex
Cabergoline is a medicine that helps lower the amount of prolactin in your body.
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conjugated estrogens
Premarin
Premarin Intravenous is an injectable medicine that contains estrogen hormones.
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Medication Guides
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What the FDA Data Shows for clomiphene
The FDA label for clomiphene (sold under brand names such as Clomid, Serophene) classifies it as a prescription-only medication in the Selective Estrogen Receptor Modulator (Fertility) class. Clomiphene citrate is used to treat women who have problems with ovulation and want to get pregnant. Official labeling lists 9 commonly reported side effects, including Ovarian enlargement, Hot flashes, Abdominal or pelvic discomfort, bloating.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 770 voluntary reports. Interaction data is drawn directly from FDA-approved prescribing information. NADAC pricing from CMS shows a generic unit cost of $7.55.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: September 18, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages