Prescription medicine
Prochlorperazine Brand names: Compro; first approved as Compazine
Prochlorperazine (Compro) is a prescription medicine with an FDA approval on record since 1956. FDA's NDC Directory lists it from 45 generic labelers, and pharmacies paid $0.162 per prochlorperazine 10 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
- Boxed warning
Check it at the source: the prochlorperazine FDA label on DailyMed (effective January 27, 2026, GLENMARK PHARMACEUTICALS INC., USA); the NDA 10571 record on Drugs@FDA; every prochlorperazine label on DailyMed.
Highlights of the record
FDA label of January 27, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5% compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Prochlorperazine maleate is not approved for the treatment of patients with dementia-related psychosis (see WARNINGS ).
Used for
From the label: indications and usageFor control of severe nausea and vomiting.
Forms and strengths
- 5 mg
- 10 mg
- 25 mg
- 5 mg/ml
Tablet; film-coated tablet; injection; suppository; injection (solution).
On the market
- Earliest approval on file
- October 23, 1956 Compazine, Glaxosmithkline; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 40 first July 5, 1979; 21 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 45 of which 45 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.162 per tablet Prochlorperazine 10 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 3 since 2019 1 Class I among all firms' recalls; latest March 13, 2025
- FAERS reports
- 37,667 through July 30, 2026
What is prochlorperazine used for?
From the label: indications and usageFor control of severe nausea and vomiting. For the treatment of schizophrenia. Prochlorperazine is effective for the short-term treatment of generalized non-psychotic anxiety. However, prochlorperazine is not the first drug to be used in therapy for most patients with non-psychotic anxiety, because certain risks associated with its use are not shared by common alternative treatments (e.g., benzodiazepines). […]
Conditions named in the indications of prochlorperazine's FDA labels, with every medicine labeled for each:
From other prochlorperazine labelsNausea and vomiting: INDICATIONS AND USAGE For control of severe nausea and vomiting.
FDA pharmacologic class: Phenothiazine.
Source: FDA drug label (PROCHLORPERAZINE MALEATE), GLENMARK PHARMACEUTICALS INC., USA, effective January 27, 2026 (SPL set 9c806152-70d0-43eb-b183-b51b12b82b31), via openFDA; the full label on DailyMed
Is there a generic for prochlorperazine (Compro)?
The FDA approved the first generic prochlorperazine on July 5, 1979. 40 generic applications are approved; 21 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists prochlorperazine from 45 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1956 earliest approval on file
- 1979 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for prochlorperazine (Compro)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.162 per Prochlorperazine 10 mg tablet, down 20% from $0.204 on October 8, 2025. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Prochlorperazine 10 mg tablet (generic)
- Compro 25 mg suppository (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Prochlorperazine 10 mg tablet | Generic | $0.162 per tablet | $4.86 | -20% |
| Prochlorperazine 25 mg supp | Generic | $4.87 per unit many times the lowest per-tablet cost; NADAC records the price, not why | n/a | -16% |
| Prochlorperazine 5 mg tablet | Generic | $0.115 per tablet | $3.44 | -24% |
| Compro 25 mg suppository | Brand | $6.74 per suppository many times the lowest per-tablet cost; NADAC records the price, not why | n/a | +29% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has prochlorperazine been recalled?
The FDA's Enforcement Report lists 3 recalls naming prochlorperazine since 2019: 1 Class I (the most serious), 1 Class II, 1 Class III; 1 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| March 13, 2025 | Class II | Glenmark Pharmaceuticals Inc., USA | CGMP Deviations |
| December 27, 2022 | Class III | Jubilant Cadista Pharmaceuticals, Inc. | Subpotent Drug: Out of specification for assay at the 18-month stability timepoint. |
| May 21, 2019 | Class I | Heritage Pharmaceuticals, Inc. | Non-Sterility:Microbial growth detected in sub lot of Amikacin Sulfate Injection, USP 1gm/4 mL (250mg/mL) and Prochlorperazine Edisylate Injection, USP … |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the prochlorperazine label say about other medicines?
The prochlorperazine label names 1 other medicine in its interaction, contraindication or warning sections. The labels of 4 other medicines name prochlorperazine. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Lithium | warnings | An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and FBS) has occurred in a few patients treated with lithium plus an antipsychotic. |
Other labels that name prochlorperazine
Source: FDA drug label (PROCHLORPERAZINE MALEATE), GLENMARK PHARMACEUTICALS INC., USA, effective January 27, 2026 (SPL set 9c806152-70d0-43eb-b183-b51b12b82b31), via openFDA; the full label on DailyMed
What do FAERS reports show for prochlorperazine?
The FDA Adverse Event Reporting System holds 37,667 reports that list prochlorperazine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 5,182 are coded as a death and 15,323 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as prochlorperazine?
11 other medicines are given the same way (oral) and in the same FDA class as prochlorperazine or labeled mainly for the same use (nausea and vomiting), the same class first. Nausea and vomiting lists all 16 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Chlorpromazine | Schizophrenia, Nausea and vomiting | 22 labelers | $0.552 per tablet 100 mg tablet | No current entry |
| Perphenazine | Schizophrenia, Nausea and vomiting | 16 labelers | $0.161 per tablet 4 mg tablet | No current entry |
| Trifluoperazine | Anxiety, Schizophrenia | 6 labelers | $0.579 per tablet 2 mg tablet | No current entry |
| Amitriptyline and perphenazine | Anxiety | 1 labeler | n/a | No current entry |
| Ondansetron | Nausea and vomiting | 60 labelers | $0.0582 per tablet 4 mg tablet | No current entry |
| Meclizine | Nausea and vomiting | 24 labelers | $0.0442 per tablet 12.5 mg tablet | No current entry |
| Dimenhydrinate | Nausea and vomiting | none listed | $0.0575 per tablet 50 mg tablet | No current entry |
| Aprepitant | Nausea and vomiting | 5 labelers | $46.42 per capsule 40 mg capsule | A presentation being discontinued |
Every medicine labeled for the same conditions as prochlorperazine
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does prochlorperazine compare with medicines for the same use?
6 side-by-side pages set prochlorperazine beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to prochlorperazine
- 11 medicines for the same use
- Other phenothiazines
- the pharmacologic class, with prices and generics
- Prochlorperazine side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other