Prescription medication · Oxazolidinone Antibiotic
linezolid
Also sold as Zyvox. Linezolid treats pneumonia, skin infections, and infections caused by certain drug-resistant bacteria.
Data updated 2026-05-15
- 28,005
- FDA reportsModerately reported
- 29
- InteractionsSeveral interactions
- $1.95
- Generic price (NADAC)
What the data shows
linezolid (Zyvox) is a prescription Oxazolidinone Antibiotic, reported at a middle-of-the-pack volume (28,005 FDA reports), with 29 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
linezolid (Zyvox) is a prescription Oxazolidinone Antibiotic. Linezolid treats pneumonia, skin infections, and infections caused by certain drug-resistant bacteria.
Linezolid is an antibiotic that fights bacteria in your body. It is used to treat different types of infections.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$1.95/unit
Generic Available
Yes (16 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Linezolid treats pneumonia, skin infections, and infections caused by certain drug-resistant bacteria.
Common side effects
Diarrhea, Vomiting, Headache
Key warnings
Linezolid can cause several serious side effects.
The sections below are summarized in plain English from linezolid's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Linezolid works by stopping the growth of bacteria. It blocks bacteria from making proteins that they need to live and multiply. This helps your body fight off the infection.
Side Effects (from patient reports)
Based on 28,005 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for linezolid, by number of reports
- Thrombocytopenia
Thrombocytopenia
2,032 reports
- Anaemia
Anaemia
1,601 reports
- Drug Interaction
Drug Interaction
1,381 reports
- Nausea
Nausea
1,301 reports
- Vomiting
Vomiting
1,063 reports
- Diarrhoea
Diarrhoea
1,003 reports
- Platelet Count Decreased
Platelet Count Decreased
1,001 reports
- Pyrexia
Pyrexia
981 reports
- Lactic Acidosis
Lactic Acidosis
938 reports
- Neuropathy Peripheral
Neuropathy Peripheral
901 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for linezolid each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where linezolid sits
linezolid has more FDA adverse-event reports than 62% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is linezolid; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 28,005 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
28,005
Reports Mentioning Death
5,204
18.6% of reports — not proof of cause
Hospitalization Reports
11,593
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | THROMBOCYTOPENIA | 2,032 |
| 4 | ANAEMIA | 1,601 |
| 5 | DRUG INTERACTION | 1,381 |
| 6 | NAUSEA | 1,301 |
| 7 | VOMITING | 1,063 |
| 8 | DIARRHOEA | 1,003 |
| 9 | PLATELET COUNT DECREASED | 1,001 |
| 10 | PYREXIA | 981 |
| 11 | LACTIC ACIDOSIS | 938 |
| 12 | NEUROPATHY PERIPHERAL | 901 |
| 13 | SEROTONIN SYNDROME | 874 |
| 14 | ACUTE KIDNEY INJURY | 867 |
| 15 | PANCYTOPENIA | 853 |
| 16 | DEATH | 762 |
| 17 | CONDITION AGGRAVATED | 728 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Linezolid can cause several serious side effects. It can lower your blood cell counts, so your doctor will monitor your blood. It can also cause nerve problems, especially if you take it for more than 28 days. Tell your doctor right away if you have vision changes, numbness, or tingling. Linezolid can also interact with certain antidepressants and cause a dangerous condition called serotonin syndrome. Diarrhea can also occur.
Known Drug Interactions
Intervention Citalopram is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration (2.5) , Contraindications (4) , Warnings and Precautions (5.3) ] .
Mechanism: Linezolid acts like a special type of medicine called an MAO inhibitor, which can cause a dangerous buildup of a brain chemical called serotonin when mixed with citalopram.
Intervention: Escitalopram is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [ see Dosage and Administration (2.7) , Contraindications (4) , and Warnings and Precautions (5.2) ] Pimozide Clinical Impact: Concomitant use of racemic citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias compared to use of racemic citalopram alone [ see Clinical Pharmacology (12.3) ].
Mechanism: Linezolid acts as a special type of medicine that stops the body from clearing serotonin, which can cause a dangerous reaction when mixed with escitalopram.
Intervention Mirtazapine is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.3) ]. Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact The concomitant use of serotonergic drugs with mirtazapine increases the risk of serotonin syndrome.
Mechanism: Linezolid blocks the breakdown of a brain chemical called serotonin, and adding mirtazapine can cause levels to become dangerously high.
Intervention Paroxetine is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration ( 2.5 ), Contraindications ( 4 ), Warnings and Precautions ( 5.2 )] . Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Pimozide and Thioridazine Clinical Impact Increased plasma concentrations of pimozide and thioridazine, drugs with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.
Mechanism: Linezolid acts like a specific brain chemical blocker that, when mixed with paroxetine, can cause a dangerous reaction in the nervous system. This can lead to serious side effects that affect your whole body.
7 DRUG INTERACTIONS Selective Serotonin Reuptake Inhibitors: Monitor patients for serotonin syndrome ( 7.3 ) Sympathomimetic Medications: Monitor patients for hypertension ( 7.5 ) Tyramine: Risk of severe hypertension ( 7.6 ) 7.1 MAO Inhibitors (MAOIs) XADAGO is contraindicated for use with other drugs in the MAOIs class or other drugs that are potent inhibitors of monoamine oxidase (e.g., linezolid, an oxazolidinone antibacterial, which also has reversible nonselective MAO inhibition activity).
Mechanism: Both drugs stop the body from breaking down certain chemicals, which can lead to a toxic buildup in your system.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take linezolid if I am allergic to it?
Can I take linezolid with antidepressants?
How long can I take linezolid?
Will linezolid affect my blood counts?
Can linezolid cause nerve damage?
Does linezolid interact with food?
What should I do if I get diarrhea while taking linezolid?
Can linezolid affect my blood pressure?
Is linezolid safe for people with kidney problems?
Can linezolid cause low blood sugar?
What are the common side effects of linezolid?
Does linezolid interact with other medications?
What drug class is linezolid?
What pregnancy or breastfeeding source fields are listed for linezolid?
Related Medications in Oxazolidinone Antibiotic
Other drugs grouped near linezolid - same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with linezolid →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with linezolid →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with linezolid →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with linezolid →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with linezolid →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for linezolid: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 28,005.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 18.58%.
- gentamicin Δ 0.07 pts · 12,687 reports · Aminoglycoside Antibiotic 18.65%death share
- phytonadione Δ 0.09 pts · 8,078 reports · Vitamin K Supplement 18.67%death share
- goserelin Δ 0.14 pts · 12,855 reports · GnRH Agonist 18.44%death share
- chlorpromazine Δ 0.14 pts · 6,862 reports · Typical Antipsychotic (Phenothiazine) 18.73%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for linezolid
The FDA label for linezolid (sold under brand names such as Zyvox) classifies it as a prescription-only medication in the Oxazolidinone Antibiotic class. Linezolid treats pneumonia, skin infections, and infections caused by certain drug-resistant bacteria. Official labeling lists 5 commonly reported side effects, including Diarrhea, Vomiting, Headache.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 28,005 voluntary reports. The database also lists 29 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $1.95.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: January 30, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages