Prescription medicine
Ethacrynic acid Brand names: Edecrin
Ethacrynic acid (Edecrin) is a prescription medicine with an FDA approval on record since 1967. FDA's NDC Directory lists it from 10 generic labelers, and pharmacies paid $0.807 per ethacrynic acid 25 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the ethacrynic acid FDA label on DailyMed (effective August 31, 2020, Bausch Health US, LLC); the NDA 16092 record on Drugs@FDA; every ethacrynic acid label on DailyMed.
Highlights of the record
FDA label of August 31, 2020; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageEDECRIN is indicated for treatment of edema when an agent with greater diuretic potential than those commonly employed is required.
Forms and strengths
- 25 mg
- 50 mg/50ml
Tablet; injection (powder) for solution; injection (powder) (lyophilized) for solution.
On the market
- Earliest approval on file
- January 10, 1967 Edecrin, Bausch; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 14 first July 29, 2015; 10 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 12 of which 10 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.807 per tablet Ethacrynic acid 25 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 2 since 2020 0 Class I among all firms' recalls; latest May 13, 2020
- FAERS reports
- 551 through July 30, 2026
What is ethacrynic acid used for?
From the label: indications and usageEDECRIN is indicated for treatment of edema when an agent with greater diuretic potential than those commonly employed is required. 1. Treatment of the edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. 2. Short-term management of ascites due to malignancy, idiopathic edema, and lymphedema. 3. Short-term management of hospitalized pediatric patients, other than infants, with congenital heart disease or the nephrotic syndrome. 4. […]
Conditions named in the indications of ethacrynic acid's FDA labels, with every medicine labeled for each:
From other ethacrynic acid labelsEdema (fluid retention): INDICATIONS AND USAGE EDECRIN is indicated for treatment of edema when an agent with greater diuretic potential than those commonly employed is required.
FDA pharmacologic class: Loop Diuretic.
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
Is there a generic for ethacrynic acid (Edecrin)?
The FDA approved the first generic ethacrynic acid on July 29, 2015. 14 generic applications are approved; 10 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists ethacrynic acid from 10 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1967 earliest approval on file
- 2015 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for ethacrynic acid (Edecrin)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.807 per Ethacrynic acid 25 mg tablet, down 19% from $0.993 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Ethacrynic acid 25 mg tablet (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Ethacrynic acid 25 mg tablet | Generic | $0.807 per tablet | $24.20 | -19% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has ethacrynic acid been recalled?
The FDA's Enforcement Report lists 2 recalls naming ethacrynic acid since 2020: 0 Class I (the most serious), 1 Class II, 1 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| May 13, 2020 | Class III | West-Ward Columbus Inc | Failed Impurities/Degradation Specifications: Out of Specification for impurity 6 and total degradants. |
| January 31, 2020 | Class II | Zydus Pharmaceuticals USA Inc | cGMP Deviations |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the ethacrynic acid label say about other medicines?
The ethacrynic acid label names 2 other medicines in its interaction, contraindication or warning sections. The labels of 9 other medicines name ethacrynic acid. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Lithium | drug interactions | Drug Interactions Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. |
| Warfarin | drug interactions | A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. |
Other labels that name ethacrynic acid
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
What do FAERS reports show for ethacrynic acid?
The FDA Adverse Event Reporting System holds 551 reports that list ethacrynic acid among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 66 are coded as a death and 224 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as ethacrynic acid?
8 other medicines are given the same way (oral) and in the same FDA class as ethacrynic acid or labeled mainly for the same use (edema (fluid retention)), the same class first. Edema (fluid retention) lists all 12 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Furosemide | Heart failure | 33 labelers | $0.026 per tablet 20 mg tablet | In shortage |
| Bumetanide | Heart failure | 24 labelers | $0.108 per tablet 1 mg tablet | Resolved |
| Torsemide | Heart failure | 20 labelers | $0.0636 per tablet 20 mg tablet | No current entry |
| Spironolactone | Heart failure, Edema (fluid retention) | 38 labelers | $0.0426 per tablet 25 mg tablet | A presentation being discontinued |
| Hydrochlorothiazide | Heart failure, Edema (fluid retention) | 44 labelers | $0.0115 per tablet 25 mg tablet | A presentation being discontinued |
| Hydrochlorothiazide and spironolactone | Heart failure, Edema (fluid retention) | 6 labelers | $0.483 per tablet 25-25 tablet | No current entry |
| Triamterene | Heart failure, Edema (fluid retention) | 3 labelers | $5.98 per capsule 50 mg capsule | No current entry |
| Chlorothiazide | Heart failure, Edema (fluid retention) | none listed | n/a | A presentation being discontinued |
Every medicine labeled for the same conditions as ethacrynic acid
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does ethacrynic acid compare with medicines for the same use?
1 side-by-side page set ethacrynic acid beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to ethacrynic acid
- 8 medicines for the same use
- Other loop diuretics
- the pharmacologic class, with prices and generics
- Ethacrynic acid side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other