Prescription medication · Anticonvulsant (Barbiturate)
phenobarbital
Also sold as Luminal. This medicine is used to treat generalized and partial seizures.
Data updated 2026-05-15
- 13,998
- FDA reportsModerately reported
- 59
- InteractionsMany interactions
- In shortage
- FDA status
What the data shows
phenobarbital (Luminal) is a prescription Anticonvulsant (Barbiturate), reported less often than most tracked drugs (13,998 FDA reports), with 59 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
phenobarbital (Luminal) is a prescription Anticonvulsant (Barbiturate). This medicine is used to treat generalized and partial seizures.
Phenobarbital is a medicine that can help control seizures and calm you down. It belongs to a class of drugs called barbiturates.
Verify with FDA → · CMS NADAC pricing →
Drug Shortage Alert
phenobarbital is currently listed as to be discontinued by the FDA. Affected manufacturer: Endo Pharmaceuticals, Inc..
View all drug shortages →Drug Pricing (NADAC)
Generic Price
$0.24/unit
Generic Available
Yes (0 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: PHENOBARBITAL 100 MG TABLET
Same CMS presentation as the headline generic unit price above (3 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: -21.9% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| June 19, 2024 | $0.3093/EA | - | 2 |
| October 23, 2024 | $0.3037/EA | -1.8% | 2 |
| December 18, 2024 | $0.2373/EA | -21.9% | 10 |
What it does
This medicine is used to treat generalized and partial seizures.
Common side effects
Drowsiness, Sedation, Lethargy
Key warnings
You should not take this medicine if you are allergic to barbiturates.
The sections below are summarized in plain English from phenobarbital's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Phenobarbital works by slowing down the activity of your brain and nervous system. It increases the effects of a natural chemical in the body called GABA. This helps to reduce seizures and promote relaxation.
Side Effects (from patient reports)
Based on 13,998 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for phenobarbital, by number of reports
- Seizure
Seizure
1,534 reports
- Drug Interaction
Drug Interaction
635 reports
- Toxicity To Various Agents
Toxicity To Various Agents
621 reports
- Status Epilepticus 482
Status Epilepticus
482 reports
- Multiple-Drug Resistance 442
Multiple-Drug Resistance
442 reports
- Somnolence 433
Somnolence
433 reports
- Condition Aggravated 413
Condition Aggravated
413 reports
- Epilepsy 397
Epilepsy
397 reports
- Fall 397
Fall
397 reports
- Hypotension 391
Hypotension
391 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for phenobarbital each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where phenobarbital sits
phenobarbital has more FDA adverse-event reports than 47% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is phenobarbital; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 13,998 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
13,998
Reports Mentioning Death
1,733
12.4% of reports — not proof of cause
Hospitalization Reports
5,401
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | SEIZURE | 1,534 |
| 4 | DRUG INTERACTION | 635 |
| 5 | TOXICITY TO VARIOUS AGENTS | 621 |
| 6 | STATUS EPILEPTICUS | 482 |
| 7 | MULTIPLE-DRUG RESISTANCE | 442 |
| 8 | SOMNOLENCE | 433 |
| 9 | CONDITION AGGRAVATED | 413 |
| 10 | EPILEPSY | 397 |
| 11 | FALL | 397 |
| 12 | HYPOTENSION | 391 |
| 13 | PYREXIA | 377 |
| 15 | CONVULSION | 369 |
| 16 | FATIGUE | 342 |
| 17 | DEATH | 328 |
| 18 | VOMITING | 325 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
You should not take this medicine if you are allergic to barbiturates. Also, do not take it if you have a history of porphyria, severe liver problems, or breathing problems.
Known Drug Interactions
Anticonvulsants carbamazepine , phenobarbital, primidone, phenytoin ↓ nirmatrelvir/ritonavir Co-administration contraindicated due to potential loss of virologic response and possible resistance [see Contraindications (4) ] .
Mechanism: Phenobarbital speeds up how fast your body breaks down the antiviral, which lowers the amount of medicine in your blood. This can stop the treatment from working and might lead to drug resistance.
CYP3A Inducers Do not use ranolazine with CYP3A inducers such as rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, and St.
Mechanism: Phenobarbital triggers your liver to process ranolazine too quickly, meaning there won't be enough medicine in your blood.
Carbamazepine (CYP450 Induction) Not Studied In Vivo or In Vitro , but Likely to Result in Significant Reduction Contraindicated Long Acting Barbiturates (e.g., phenobarbital, mephobarbital) (CYP450 Induction) Not Studied In Vivo or In Vitro , but Likely to Result in Significant Reduction Contraindicated Phenytoin (CYP450 Induction) Significantly Reduced Increase voriconazole maintenance dose from 4 mg/kg to 5 mg/kg IV every 12 hours or from 200 mg to 400 mg orally every 12 hours (100 mg to 200 mg orally every 12 hours in patients weighing less than 40 kg).
Mechanism: Phenobarbital causes the body to process voriconazole much faster than normal, which significantly lowers the amount of medicine in your system. This makes the treatment much less likely to fight off an infection.
Examples: Rifampin, phenytoin, phenobarbital, ritonavir Insulin or Insulin Secretagogues Clinical Impact: The risk of hypoglycemia is increased when INVOKANA is used concomitantly with insulin secretagogues (e.g., sulfonylurea) or insulin.
Mechanism: Phenobarbital speeds up the breakdown of canagliflozin in your body, which can make the diabetes medicine less effective.
( 7.1 ) Phenobarbital and Clobazam: Reduce dosage as needed when used concomitantly with XCOPRI. phenobarbital ↑ plasma concentrations Because of a potential for an increase in the risk of adverse reactions from these drugs, consider a reduction in dosage of phenobarbital or clobazam, as clinically appropriate, when used concomitantly with XCOPRI.
Mechanism: Cenobamate causes the levels of phenobarbital in your blood to go up. This makes it more likely that you will have a bad reaction to the phenobarbital.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I drink alcohol while taking phenobarbital?
Will phenobarbital cure my seizures?
How long does it take for phenobarbital to start working?
Can I stop taking phenobarbital suddenly?
Does phenobarbital interact with other medications?
Can phenobarbital cause mood changes?
What should I do if I experience side effects?
Can children take phenobarbital?
Will phenobarbital make me feel tired?
Can I drive while taking phenobarbital?
What are the common side effects of phenobarbital?
Does phenobarbital interact with other medications?
What drug class is phenobarbital?
What pregnancy or breastfeeding source fields are listed for phenobarbital?
Has phenobarbital been recalled?
Is phenobarbital currently in shortage?
Active Recalls
Lack of Assurance of Sterility: FDA inspection findings resulted in concerns regarding quality control processes
Lowlite Investments, Inc. D/B/A Olympia Pharmacy
Related Medications in Anticonvulsant (Barbiturate)
Other drugs grouped near phenobarbital - same-class peers and common alternatives.
brivaracetam
Briviact
Brivaracetam is a medicine used to treat partial-onset seizures.
Compare with phenobarbital →
cannabidiol
Epidiolex
Epidiolex is a medicine that contains cannabidiol.
Compare with phenobarbital →
carbamazepine
Tegretol
Carbamazepine is a medicine used to control seizures and treat nerve pain.
Compare with phenobarbital →
cenobamate
Xcopri
Xcopri is a medicine used to treat partial-onset seizures in adults.
Compare with phenobarbital →
clobazam
Onfi, Sympazan
Clobazam oral suspension is a medicine used with other medicines to treat seizures caused by Lennox-Gastaut syndrome.
Compare with phenobarbital →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for phenobarbital: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 13,998.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 12.38%.
- olanzapine Δ 0.01 pts · 103,356 reports · Atypical Antipsychotic 12.37%death share
- hydralazine Δ 0.06 pts · 28,498 reports · Vasodilator 12.32%death share
- dipyridamole Δ 0.09 pts · 3,682 reports · Antiplatelet / Vasodilator 12.47%death share
- nortriptyline Δ 0.13 pts · 5,503 reports · Tricyclic Antidepressant (TCA) 12.25%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for phenobarbital
The FDA label for phenobarbital (sold under brand names such as Luminal) classifies it as a prescription-only medication in the Anticonvulsant (Barbiturate) class. This medicine is used to treat generalized and partial seizures. Official labeling lists 4 commonly reported side effects, including Drowsiness, Sedation, Lethargy.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 13,998 voluntary reports. The database also lists 59 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.24.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: January 5, 2022
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages