Prescription medication · Cardiac Glycoside
digoxin
Also sold as Lanoxin. Digoxin is used to treat mild to moderate heart failure in adults.
Data updated 2026-05-15
- 70,341
- FDA reportsOften reported
- 120
- InteractionsMany interactions
- $1.17
- Generic price (NADAC)
What the data shows
digoxin (Lanoxin) is a prescription Cardiac Glycoside, more reported than most tracked drugs (70,341 FDA reports), with 120 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
digoxin (Lanoxin) is a prescription Cardiac Glycoside. Digoxin is used to treat mild to moderate heart failure in adults.
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$1.17/unit
Generic Available
Yes (10 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Digoxin is used to treat mild to moderate heart failure in adults.
Common side effects
Nausea, Vomiting, Diarrhea
Key warnings
Digoxin can cause serious side effects, including dangerous heart rhythms.
The sections below are summarized in plain English from digoxin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Side Effects (from patient reports)
Based on 70,341 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for digoxin, by number of reports
- Dyspnoea
Dyspnoea
6,065 reports
- Nausea
Nausea
4,754 reports
- Dizziness
Dizziness
4,439 reports
- Fatigue
Fatigue
4,175 reports
- Atrial Fibrillation
Atrial Fibrillation
3,974 reports
- Diarrhoea
Diarrhoea
3,743 reports
- Asthenia
Asthenia
3,617 reports
- Death
Death
3,396 reports
- Vomiting
Vomiting
3,363 reports
- Hypotension
Hypotension
3,172 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for digoxin each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where digoxin sits
digoxin has more FDA adverse-event reports than 80% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is digoxin; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 70,341 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 1999–2025.
Total Reports
70,341
Reports Mentioning Death
13,641
19.4% of reports — not proof of cause
Hospitalization Reports
35,786
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DYSPNOEA | 6,065 |
| 2 | NAUSEA | 4,754 |
| 3 | DIZZINESS | 4,439 |
| 4 | FATIGUE | 4,175 |
| 5 | ATRIAL FIBRILLATION | 3,974 |
| 6 | DIARRHOEA | 3,743 |
| 7 | ASTHENIA | 3,617 |
| 8 | DEATH | 3,396 |
| 9 | VOMITING | 3,363 |
| 10 | HYPOTENSION | 3,172 |
| 11 | CARDIAC FAILURE CONGESTIVE | 3,136 |
| 12 | PAIN | 2,986 |
| 13 | FALL | 2,902 |
| 14 | DRUG INTERACTION | 2,799 |
| 15 | PNEUMONIA | 2,727 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Known Drug Interactions
Digoxin Some calcium blockers may increase the concentration of digitalis preparations in the blood. Nicardipine hydrochloride capsules usually do not alter the plasma levels of digoxin; however, serum digoxin levels should be evaluated after concomitant therapy with nicardipine hydrochloride capsules are initiated.
Mechanism: Nicardipine may cause digoxin to build up in your bloodstream by changing how your body handles the drug.
Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets. 7.12 Digoxin Increased plasma concentrations of...
Mechanism: Posaconazole can cause the amount of digoxin in your blood to rise to higher levels. This increases the risk of digoxin toxicity, which can affect your heart rhythm.
Antiarrthymics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes Sotalol Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in patients receiving digoxin.
Mechanism: Using these two drugs together can increase the chance of developing dangerous, irregular heartbeats. This may be due to the drugs themselves or the heart condition being treated.
Antiarrthymics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes Sotalol Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in patients receiving digoxin.
Mechanism: Taking these medicines at the same time increases the risk of a serious and potentially fatal irregular heart rhythm. Both drugs change how electricity moves through the heart.
Hyperpolarization-activated cyclic nucleotide-gated channel blocker Ivabradine Can increase the risk of bradycardia.
Mechanism: Both of these medications work to slow down the heart. When taken together, they can cause the heart rate to drop to a level that is too slow.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What should I do if I feel sick after taking digoxin?
Can I take other medicines with digoxin?
How often will I need blood tests?
What are the signs of digoxin toxicity?
Can I stop taking digoxin on my own?
Does digoxin cure heart failure?
Will digoxin affect my ability to drive?
What if I have kidney problems?
Can digoxin cause mental changes?
Are there any foods I should avoid while taking digoxin?
What are the common side effects of digoxin?
Does digoxin interact with other medications?
What drug class is digoxin?
What pregnancy or breastfeeding source fields are listed for digoxin?
Related Medications in Cardiac Glycoside
Other drugs grouped near digoxin - same-class peers and common alternatives.
adenosine
Adenocard
Adenosine (Adenocard) is a medicine used to treat certain types of irregular heartbeats.
Compare with digoxin →
amiodarone
Cordarone, Pacerone
Amiodarone (Pacerone) is a medicine used to treat life-threatening, irregular heartbeats.
Compare with digoxin →
atropine
AtroPen
Atropine is a medicine that can temporarily block severe effects on your body.
Compare with digoxin →
bumetanide
Bumex
Bumetanide is a water pill (diuretic).
Compare with digoxin →
carvedilol
Coreg
Carvedilol is a medicine that lowers blood pressure and helps your heart work better.
Compare with digoxin →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for digoxin: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 70,341.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 19.39%.
- ranibizumab Δ 0.01 pts · 26,174 reports · Anti-VEGF (Ophthalmic Injection) 19.38%death share
- heparin Δ 0.04 pts · 12,966 reports · Unfractionated Heparin 19.43%death share
- enzalutamide Δ 0.22 pts · 57,614 reports · Androgen Receptor Inhibitor 19.61%death share
- diazepam Δ 0.27 pts · 117,869 reports · Benzodiazepine 19.13%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for digoxin
The FDA label for digoxin (sold under brand names such as Lanoxin) classifies it as a prescription-only medication in the Cardiac Glycoside class. Digoxin is used to treat mild to moderate heart failure in adults. Official labeling lists 7 commonly reported side effects, including Nausea, Vomiting, Diarrhea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 70,341 voluntary reports. The database also lists 120 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $1.17.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: September 4, 2024
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages