Prescription medicine
Atenolol and chlorthalidone First approved as Tenoretic
Atenolol and chlorthalidone (Tenoretic) is a prescription medicine with an FDA approval on record since 1984. FDA's NDC Directory lists it from 10 generic labelers, and pharmacies paid $0.335 per unit (Atenolol-chlorthalidone 100-25) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the atenolol and chlorthalidone FDA label on DailyMed (effective January 16, 2024, Unichem Pharmaceuticals (USA), Inc.); the NDA 18760 record on Drugs@FDA; every atenolol and chlorthalidone label on DailyMed.
Highlights of the record
FDA label of January 16, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageAtenolol and chlorthalidone tablets are indicated for the treatment of hypertension, to lower blood pressure.
Forms and strengths
- 25 mg / 50 mg
- 50 mg / 25 mg
- 100 mg / 25 mg
Tablet.
On the market
- Earliest approval on file
- June 8, 1984 Tenoretic 100, Twi Pharms; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 9 first May 31, 1990; 5 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 10 of which 10 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.335 per unit Atenolol-chlorthalidone 100-25
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 753 through July 30, 2026
What is atenolol and chlorthalidone used for?
From the label: indications and usageAtenolol and chlorthalidone tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including atenolol and chlorthalidone. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. […]
Conditions named in the indications of atenolol and chlorthalidone's FDA labels, with every medicine labeled for each:
From other atenolol and chlorthalidone labelsHigh blood pressure: INDICATIONS AND USAGE Atenolol and chlorthalidone tablets are indicated for the treatment of hypertension, to lower blood pressure.
FDA pharmacologic class: Thiazide-like Diuretic and beta-Adrenergic Blocker.
Source: FDA drug label (Atenolol and Chlorthalidone), Unichem Pharmaceuticals (USA), Inc., effective January 16, 2024 (SPL set a85d28c1-e812-4c12-aa67-136bff3610e5), via openFDA; the full label on DailyMed
Is there a generic for atenolol and chlorthalidone (Tenoretic)?
The FDA approved the first generic atenolol and chlorthalidone on May 31, 1990. 9 generic applications are approved; 5 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists atenolol and chlorthalidone from 10 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1984 earliest approval on file
- 1990 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for atenolol and chlorthalidone (Tenoretic)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.335 per unit (Atenolol-chlorthalidone 100-25), down 12% from $0.379 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Atenolol-chlorthalidone 50-25 (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Atenolol-chlorthalidone 100-25 | Generic | $0.335 per unit | n/a | -12% |
| Atenolol-chlorthalidone 50-25 | Generic | $0.222 per unit | n/a | -23% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the atenolol and chlorthalidone label say about other medicines?
The atenolol and chlorthalidone label names 8 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Amiodarone | drug interactions | Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers. |
| Clonidine | drug interactions | Beta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. |
| Diltiazem | warnings | Concomitant Use of Calcium Channel Blockers Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem. |
| Disopyramide | drug interactions | Calcium channel blockers may also have an additive effect when given with atenolol and chlorthalidone tablets (See WARNINGS .) Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects. |
| Epinephrine | drug interactions | Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction. |
| Indomethacin | drug interactions | Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. |
| Lithium | drug interactions | Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. |
| Verapamil | warnings | Concomitant Use of Calcium Channel Blockers Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem. |
Source: FDA drug label (Atenolol and Chlorthalidone), Unichem Pharmaceuticals (USA), Inc., effective January 16, 2024 (SPL set a85d28c1-e812-4c12-aa67-136bff3610e5), via openFDA; the full label on DailyMed
What do FAERS reports show for atenolol and chlorthalidone?
The FDA Adverse Event Reporting System holds 753 reports that list atenolol and chlorthalidone among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 61 are coded as a death and 264 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as atenolol and chlorthalidone?
72 other medicines are given the same way (oral) and in the same FDA class as atenolol and chlorthalidone or labeled mainly for the same use (high blood pressure), the same class first. High blood pressure lists all 88 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Metoprolol | High blood pressure | 64 labelers | $0.085 per tablet 100 mg tablet | A presentation being discontinued |
| Propranolol | High blood pressure | 38 labelers | $0.0493 per tablet 20 mg tablet | In shortage |
| Carvedilol | High blood pressure | 41 labelers | $0.0179 per tablet 6.25 mg tablet | No current entry |
| Labetalol | High blood pressure | 31 labelers | $0.215 per tablet 300 mg tablet | No current entry |
| Nebivolol | High blood pressure | 23 labelers | $0.141 per tablet 10 mg tablet | A presentation being discontinued |
| Metolazone | High blood pressure | 19 labelers | $0.233 per tablet 2.5 mg tablet | No current entry |
| Nadolol | High blood pressure | 16 labelers | $0.147 per tablet 20 mg tablet | No current entry |
| Bisoprolol | High blood pressure | 24 labelers | $0.114 per tablet 5 mg tablet | No current entry |
Every medicine labeled for the same conditions as atenolol and chlorthalidone
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to atenolol and chlorthalidone
- 72 medicines for the same use
- Other thiazide-like diuretics
- the pharmacologic class, with prices and generics
- Atenolol and chlorthalidone side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other