Bumetanide Brand names: Bumex, Enbumyst

What is bumetanide used for?

From the label: indications and usage

Bumex tablets are indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome. Almost equal diuretic response occurs after oral and parenteral administration of bumetanide. Therefore, if impaired gastrointestinal absorption is suspected or oral administration is not practical, bumetanide should be given by the intramuscular or intravenous route. Successful treatment with Bumex tablets following instances of allergic reactions to furosemide suggests a lack of cross-sensitivity.

Conditions named in the indications of bumetanide's FDA labels, with every medicine labeled for each:

• Heart failure

From other bumetanide labels

Heart failure: INDICATIONS AND USAGE Bumex tablets are indicated for the treatment of edema associated with congestive heart failure, hepatic and renal disease, including the nephrotic syndrome.

FDA pharmacologic class: Loop Diuretic.

What does the patient leaflet for bumetanide say first?

The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.

From the patient leaflet: What is the most important information I should know about ENBUMYST?

ENBUMYST is a diuretic that causes fluid loss and may lead to abnormalities with blood electrolytes and body energy systems (metabolic). Too much fluid loss can lead to dehydration and decreased blood volume and increase your risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The chance of getting these abnormalities is higher in people who are elderly, use higher doses, or who do not get enough electrolytes by mouth. Your healthcare provider should do blood tests to check for these abnormalities during treatment with ENBUMYST. You should not use ENBUMYST if you have severe electrolyte loss until it gets better. Tell your healthcare provider if you get any of the following signs or symptoms: unusual thirst dizziness or lightheadedness weakness or tiredness fast heart rate dry mouth or tongue sudden pain, redness or swelling in your joints, especially your big toe (gout) pain, swelling, redness, or warmth in your leg shortness of breath fast breathing high blood sugar dark urine skin is pale, tight, cool or clammy muscle cramps confusion See " What are the possible side effects of ENBUMYST? " for more information about side effects.

From the patient leaflet: How should I store ENBUMYST?

Store ENBUMYST at room temperature between 59°F to 77°F (15°C to 25°C). Do not freeze. Keep ENBUMYST and all medicines out of the reach of children.

Is there a generic for bumetanide (Bumex)?

The FDA approved the first generic bumetanide on October 31, 1994. 23 generic applications are approved; 20 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.

FDA's NDC Directory lists bumetanide from 36 labelers under a generic (ANDA) application and from 2 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.

The Orange Book lists no patent for Bumex tablets; a patent listed only for Enbumyst spray runs to May 14, 2045. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.

What do pharmacies pay for bumetanide (Bumex)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.108 per Bumetanide 1 mg tablet, down 25% from $0.145 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

Is bumetanide in shortage?

No bumetanide presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 12 records are all resolved, the latest updated September 30, 2026. ASHP keeps a separate shortage list, which can differ.

Every bumetanide presentation in the FDA shortage database

Has bumetanide been recalled?

The FDA's Enforcement Report lists 6 recalls naming bumetanide since 2013: 0 Class I (the most serious), 5 Class II, 1 Class III; 0 still ongoing. 2 of them are by firms that FDA's NDC Directory does not list as a maker of bumetanide and that hold no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.

What does the bumetanide label say about other medicines?

The bumetanide label names 7 other medicines in its interaction, contraindication or warning sections. The labels of 3 other medicines name bumetanide. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Other labels that name bumetanide

• Dapagliflozin

Check bumetanide against other medicines

What do FAERS reports show for bumetanide?

The FDA Adverse Event Reporting System holds 26,259 reports that list bumetanide among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 4,122 are coded as a death and 12,607 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Reports received each year

• 1,653
• 1,658
• 1,859
• 1,944
• 1,960
• 1,445
• 1,356
• 1,728
• 2,156
• 2,266
• 1,143

• 2016
• 2017
• 2018
• 2019
• 2020
• 2021
• 2022
• 2023
• 2024
• 2025
• 2026

The most reported reactions

• Dyspnoea2,649
• Fatigue (named in the label)1,734
• Death (an outcome recorded in the report)1,695
• Acute Kidney Injury1,692
• Diarrhoea (named in the label)1,577
• Nausea (named in the label)1,545
• Dizziness (named in the label)1,295
• Headache (named in the label)1,245

Side effects: the label's list and every FAERS reaction

What else is labeled for the same conditions as bumetanide?

18 other medicines are given the same way (oral) and in the same FDA class as bumetanide or labeled mainly for the same use (heart failure), the same class first. Heart failure lists all 37 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

Every medicine labeled for the same conditions as bumetanide

How does bumetanide compare with medicines for the same use?

5 side-by-side pages set bumetanide beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.

• Furosemide
• Hydrochlorothiazide
• Metolazone
• Spironolactone
• Torsemide

What next?

Alternatives to bumetanide

18 medicines for the same use

Other loop diuretics

the pharmacologic class, with prices and generics

Bumetanide side effects

the label's list beside FAERS reports

Bumetanide shortage record

every presentation, company and date

Check an interaction

what two or more labels say about each other