Prescription medication · Thiazide-Like Diuretic
indapamide
Also sold as Lozol. Indapamide is used to treat high blood pressure, either alone or with other medicines.
Data updated 2026-05-15
- 17,199
- FDA reportsModerately reported
- 3
- InteractionsFew interactions
- $0.10
- Generic price (NADAC)
What the data shows
indapamide (Lozol) is a prescription Thiazide-Like Diuretic, reported at a middle-of-the-pack volume (17,199 FDA reports), with 3 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
indapamide (Lozol) is a prescription Thiazide-Like Diuretic. Indapamide is used to treat high blood pressure, either alone or with other medicines.
Indapamide is a water pill that helps lower blood pressure and reduce fluid buildup in the body. It is used to treat high blood pressure and heart failure.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.10/unit
Generic Available
Yes (3 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Indapamide is used to treat high blood pressure, either alone or with other medicines.
Common side effects
Headache, Weakness, Constipation
Key warnings
If you have anuria (inability to urinate), you should not take this medicine.
The sections below are summarized in plain English from indapamide's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Indapamide is a diuretic, also known as a water pill. It helps your kidneys remove more salt and water from your blood, which lowers blood pressure. It also reduces fluid buildup in your body.
Side Effects (from patient reports)
Based on 17,199 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for indapamide, by number of reports
- Hyponatraemia
Hyponatraemia
1,286 reports
- Acute Kidney Injury
Acute Kidney Injury
925 reports
- Dyspnoea
Dyspnoea
898 reports
- Dizziness
Dizziness
875 reports
- Nausea
Nausea
863 reports
- Diarrhoea
Diarrhoea
843 reports
- Fatigue
Fatigue
781 reports
- Drug Interaction
Drug Interaction
756 reports
- Hypokalaemia
Hypokalaemia
746 reports
- Vomiting
Vomiting
699 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for indapamide each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where indapamide sits
indapamide has more FDA adverse-event reports than 51% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is indapamide; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 17,199 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
17,199
Reports Mentioning Death
1,091
6.3% of reports — not proof of cause
Hospitalization Reports
8,087
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | HYPONATRAEMIA | 1,286 |
| 2 | ACUTE KIDNEY INJURY | 925 |
| 3 | DYSPNOEA | 898 |
| 4 | DIZZINESS | 875 |
| 5 | NAUSEA | 863 |
| 6 | DIARRHOEA | 843 |
| 7 | FATIGUE | 781 |
| 8 | DRUG INTERACTION | 756 |
| 9 | HYPOKALAEMIA | 746 |
| 10 | VOMITING | 699 |
| 11 | MALAISE | 695 |
| 13 | FALL | 652 |
| 14 | HEADACHE | 640 |
| 15 | ASTHENIA | 639 |
| 17 | ARTHRALGIA | 608 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
If you have anuria (inability to urinate), you should not take this medicine. Also, you should not take this medicine if you are allergic to indapamide or other sulfa drugs.
Known Drug Interactions
Lithium : See WARNINGS .
Mechanism: Indapamide changes how your kidneys handle salt, which can cause lithium to stay in your body too long. This can lead to high and potentially harmful lithium levels.
Norepinephrine : Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Mechanism: Indapamide makes your blood vessels less reactive to norepinephrine. This can make norepinephrine slightly less effective at raising your blood pressure.
Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.
Mechanism: These two drugs do not appear to have any negative combined effects on the heart's electrical activity.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take indapamide with other blood pressure medicines?
What should I do if I feel dizzy after taking indapamide?
Does indapamide affect my potassium levels?
Can indapamide cause dehydration?
How long does it take for indapamide to start working?
Can I drink alcohol while taking indapamide?
Does indapamide interact with lithium?
Can indapamide affect my blood sugar?
What are the signs of low potassium?
Can I stop taking indapamide suddenly?
What are the common side effects of indapamide?
Does indapamide interact with other medications?
What drug class is indapamide?
What pregnancy or breastfeeding source fields are listed for indapamide?
Related Medications in Thiazide-Like Diuretic
Other drugs grouped near indapamide - same-class peers and common alternatives.
acebutolol
Sectral
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats.
Compare with indapamide →
aliskiren
Tekturna
Tekturna is a medicine used to treat high blood pressure.
Compare with indapamide →
amiloride
Midamor
Amiloride is a water pill that helps your body hold onto potassium.
Compare with indapamide →
amlodipine
Norvasc
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain.
Compare with indapamide →
amlodipine/benazepril
Lotrel
Lotrel is a combination medicine that contains amlodipine and benazepril.
Compare with indapamide →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for indapamide: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 17,199.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 6.34%.
- meloxicam Δ 0.00 pts · 55,835 reports · Nonsteroidal Anti-Inflammatory Drug (NSAID) 6.34%death share
- nitrofurantoin Δ 0.00 pts · 15,757 reports · Nitrofuran Antibiotic 6.35%death share
- icosapent ethyl Δ 0.03 pts · 7,801 reports · Omega-3 Fatty Acid (EPA) 6.37%death share
- latanoprost Δ 0.04 pts · 48,513 reports · Prostaglandin Analog (Ophthalmic) 6.38%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for indapamide
The FDA label for indapamide (sold under brand names such as Lozol) classifies it as a prescription-only medication in the Thiazide-Like Diuretic class. Indapamide is used to treat high blood pressure, either alone or with other medicines. Official labeling lists 6 commonly reported side effects, including Headache, Weakness, Constipation.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 17,199 voluntary reports. The database also lists 3 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $0.10.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: June 26, 2023
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages