indapamide
Brand names: Lozol
Indapamide is a water pill that helps lower blood pressure and reduce fluid buildup in the body. It is used to treat high blood pressure and heart failure.
Drug Pricing (NADAC)
Generic Price
$0.10/unit
Generic Available
Yes (3 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Indapamide is used to treat high blood pressure, either alone or with other medicines.
Common side effects
Headache, Weakness, Constipation
Key warnings
If you have anuria (inability to urinate), you should not take this medicine.
How It Works
Indapamide is a diuretic, also known as a water pill. It helps your kidneys remove more salt and water from your blood, which lowers blood pressure. It also reduces fluid buildup in your body.
How to Take It
Take indapamide once a day in the morning. The starting dose for high blood pressure is usually 1.25 mg. Your doctor may increase the dose every 4 weeks up to 5 mg daily. For edema from heart failure, the starting dose is 2.5 mg, which may be increased to 5 mg after 1 week.
Pregnancy & Breastfeeding
Talk to your doctor before taking indapamide if you are pregnant or breastfeeding. This medicine should only be used during pregnancy if it is clearly needed.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Storage
Store indapamide tablets at room temperature (68° to 77°F) in a tight, light-resistant container, away from excessive heat.
Side Effects (from patient reports)
Based on 8,671 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 17,199 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
17,199
Death-Related Reports
1,091
Hospitalization Reports
8,087
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | HYPONATRAEMIA | 1,286 |
| 2 | ACUTE KIDNEY INJURY | 925 |
| 3 | DYSPNOEA | 898 |
| 4 | DIZZINESS | 875 |
| 5 | NAUSEA | 863 |
| 6 | DIARRHOEA | 843 |
| 7 | FATIGUE | 781 |
| 8 | DRUG INTERACTION | 756 |
| 9 | HYPOKALAEMIA | 746 |
| 10 | VOMITING | 699 |
| 11 | MALAISE | 695 |
| 12 | DRUG INEFFECTIVE | 660 |
| 13 | FALL | 652 |
| 14 | HEADACHE | 640 |
| 15 | ASTHENIA | 639 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
If you have anuria (inability to urinate), you should not take this medicine. Also, you should not take this medicine if you are allergic to indapamide or other sulfa drugs.
Known Drug Interactions
Lithium : See WARNINGS .
Mechanism: Indapamide changes how your kidneys handle salt, which can cause lithium to stay in your body too long. This can lead to high and potentially harmful lithium levels.
What to do: Your doctor should regularly test your blood to make sure your lithium levels stay in a safe range.
Norepinephrine : Indapamide, like the thiazides, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Mechanism: Indapamide makes your blood vessels less reactive to norepinephrine. This can make norepinephrine slightly less effective at raising your blood pressure.
What to do: Your doctor should monitor your blood pressure to ensure the medication is still doing its job.
Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.
Mechanism: These two drugs do not appear to have any negative combined effects on the heart's electrical activity.
What to do: No special precautions are typically needed when taking these medications together.
Common Questions
Can I take indapamide with other blood pressure medicines?
What should I do if I feel dizzy after taking indapamide?
Does indapamide affect my potassium levels?
Can indapamide cause dehydration?
How long does it take for indapamide to start working?
Can I drink alcohol while taking indapamide?
Does indapamide interact with lithium?
Can indapamide affect my blood sugar?
What are the signs of low potassium?
Can I stop taking indapamide suddenly?
What are the common side effects of indapamide?
Does indapamide interact with other medications?
What drug class is indapamide?
Is indapamide safe during pregnancy?
Related Medications in Thiazide-Like Diuretic
Other drugs grouped near indapamide — same-class peers and common alternatives.
acebutolol
Sectral
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats.
Compare with indapamide →
aliskiren
Tekturna
Tekturna is a medicine used to treat high blood pressure.
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amiloride
Midamor
Amiloride is a water pill that helps your body hold onto potassium.
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amlodipine
Norvasc
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain.
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amlodipine/benazepril
Lotrel
Lotrel is a combination medicine that contains amlodipine and benazepril.
Compare with indapamide →
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What the FDA Data Shows for indapamide
The FDA label for indapamide (sold under brand names such as Lozol) classifies it as a prescription-only medication in the Thiazide-Like Diuretic class. Indapamide is used to treat high blood pressure, either alone or with other medicines. Official labeling lists 6 commonly reported side effects, including Headache, Weakness, Constipation.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 8,671 voluntary reports. The database also lists 3 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $0.10.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: June 26, 2023
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages