Prescription medicine
Indapamide First approved as Lozol
Indapamide (Lozol) is a prescription medicine with an FDA approval on record since 1983. FDA's NDC Directory lists it from 8 generic labelers, and pharmacies paid $0.109 per indapamide 1.25 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the indapamide FDA label on DailyMed (effective October 1, 2022, Actavis Pharma, Inc.); the NDA 18538 record on Drugs@FDA; every indapamide label on DailyMed.
Highlights of the record
FDA label of October 1, 2022; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageIndapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs.
Forms and strengths
- 1.25 mg
- 2.5 mg
Film-coated tablet; tablet.
On the market
- Earliest approval on file
- July 6, 1983 Lozol, Sanofi Aventis Us; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 8 first July 27, 1995; 3 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 8 of which 8 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.109 per tablet Indapamide 1.25 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 17,817 through July 30, 2026
What is indapamide used for?
From the label: indications and usageIndapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs. Indapamide tablets are also indicated for the treatment of salt and fluid retention associated with congestive heart failure. Usage in Pregnancy: The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard (see PRECAUTIONS ). Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. […]
Conditions named in the indications of indapamide's FDA labels, with every medicine labeled for each:
From other indapamide labelsHigh blood pressure: INDICATIONS AND USAGE Indapamide tablets are indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs.
Edema (fluid retention): Indapamide is indicated in pregnancy when edema is due to pathologic causes, just as it is in the absence of pregnancy (however, see PRECAUTIONS ).
FDA pharmacologic class: Thiazide-like Diuretic.
Source: FDA drug label (Indapamide), Actavis Pharma, Inc., effective October 1, 2022 (SPL set a8a4ec2c-9d4b-482b-ad29-88185c96db74), via openFDA; the full label on DailyMed
Is there a generic for indapamide (Lozol)?
The FDA approved the first generic indapamide on July 27, 1995. 8 generic applications are approved; 3 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists indapamide from 8 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1983 earliest approval on file
- 1995 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for indapamide (Lozol)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.109 per Indapamide 1.25 mg tablet, up 9% from $0.0993 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Indapamide 2.5 mg tablet (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Indapamide 1.25 mg tablet | Generic | $0.109 per tablet | $3.26 | +9% |
| Indapamide 2.5 mg tablet | Generic | $0.108 per tablet | $3.23 | -4% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the indapamide label say about other medicines?
The indapamide label names 1 other medicine in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Lithium | warnings | In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity. |
Source: FDA drug label (Indapamide), Actavis Pharma, Inc., effective October 1, 2022 (SPL set a8a4ec2c-9d4b-482b-ad29-88185c96db74), via openFDA; the full label on DailyMed
What do FAERS reports show for indapamide?
The FDA Adverse Event Reporting System holds 17,817 reports that list indapamide among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 1,137 are coded as a death and 8,336 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as indapamide?
78 other medicines are given the same way (oral) and in the same FDA class as indapamide or labeled mainly for the same use (high blood pressure), the same class first. High blood pressure lists all 88 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Chlorthalidone | High blood pressure, Heart failure, Edema (fluid retention) | 36 labelers | $0.0743 per tablet 25 mg tablet | No current entry |
| Metolazone | High blood pressure, Heart failure, Edema (fluid retention) | 19 labelers | $0.233 per tablet 2.5 mg tablet | No current entry |
| Atenolol and chlorthalidone | High blood pressure | 10 labelers | $0.335 per unit 100-25 | No current entry |
| Azilsartan and chlorthalidone | High blood pressure | none listed | $8.49 per tablet 40-12.5 mg tablet | No current entry |
| Metoprolol | High blood pressure, Heart failure | 64 labelers | $0.085 per tablet 100 mg tablet | A presentation being discontinued |
| Diltiazem | High blood pressure | 42 labelers | $0.144 per capsule 24h ER(cd) 120 mg capsule | A presentation being discontinued |
| Lisinopril | High blood pressure, Heart failure | 36 labelers | $0.0254 per tablet 20 mg tablet | No current entry |
| Propranolol | High blood pressure | 38 labelers | $0.0493 per tablet 20 mg tablet | In shortage |
Every medicine labeled for the same conditions as indapamide
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does indapamide compare with medicines for the same use?
6 side-by-side pages set indapamide beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to indapamide
- 78 medicines for the same use
- Other thiazide-like diuretics
- the pharmacologic class, with prices and generics
- Indapamide side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other