Prescription medication · Anticonvulsant
carbamazepine
Also sold as Tegretol. Carbamazepine is used to treat certain types of seizures, including partial seizures and generalized tonic-clonic seizures.
Data updated 2026-05-15
- 65,260
- FDA reportsOften reported
- 129
- InteractionsMany interactions
- 46% less
- Generic vs brandReal savings
- In shortage
- FDA status
What the data shows
carbamazepine (Tegretol) is a prescription Anticonvulsant, more reported than most tracked drugs (65,260 FDA reports), with a lower-cost generic available (46% less than brand).
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
carbamazepine (Tegretol) is a prescription Anticonvulsant. Carbamazepine is used to treat certain types of seizures, including partial seizures and generalized tonic-clonic seizures.
Carbamazepine is a medicine used to control seizures and treat nerve pain. It works by reducing abnormal electrical activity in the brain and calming nerve signals.
Verify with FDA → · CMS NADAC pricing →
Drug Shortage Alert
carbamazepine is currently listed as to be discontinued by the FDA. Affected manufacturer: Takeda Pharmaceuticals USA Inc..
View all drug shortages →Drug Pricing (NADAC)
Brand Price
$0.41/unit
Generic Price
$0.23/unit
Generic Savings
46%
Generic Available
Yes (26 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Carbamazepine is used to treat certain types of seizures, including partial seizures and generalized tonic-clonic seizures.
Common side effects
Dizziness, Drowsiness, Unsteadiness
Key warnings
Carbamazepine can cause severe skin reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be fatal.
The sections below are summarized in plain English from carbamazepine's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Carbamazepine is an anticonvulsant. It works by reducing the spread of seizure activity in the brain. It also stabilizes nerve impulses to reduce pain.
Side Effects (from patient reports)
Based on 65,260 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for carbamazepine, by number of reports
- Seizure
Seizure
3,609 reports
- Drug Interaction
Drug Interaction
3,369 reports
- Fall
Fall
3,044 reports
- Dizziness
Dizziness
2,862 reports
- Pyrexia
Pyrexia
2,689 reports
- Nausea
Nausea
2,629 reports
- Toxicity To Various Agents
Toxicity To Various Agents
2,600 reports
- Vomiting
Vomiting
2,505 reports
- Convulsion
Convulsion
2,504 reports
- Fatigue
Fatigue
2,473 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for carbamazepine each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where carbamazepine sits
carbamazepine has more FDA adverse-event reports than 79% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is carbamazepine; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 65,260 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2001–2025.
Total Reports
65,260
Reports Mentioning Death
5,503
8.4% of reports — not proof of cause
Hospitalization Reports
25,279
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | SEIZURE | 3,609 |
| 3 | DRUG INTERACTION | 3,369 |
| 4 | FALL | 3,044 |
| 5 | DIZZINESS | 2,862 |
| 6 | PYREXIA | 2,689 |
| 7 | NAUSEA | 2,629 |
| 8 | TOXICITY TO VARIOUS AGENTS | 2,600 |
| 10 | VOMITING | 2,505 |
| 11 | CONVULSION | 2,504 |
| 12 | FATIGUE | 2,473 |
| 13 | SOMNOLENCE | 2,333 |
| 14 | PAIN | 2,293 |
| 15 | RASH | 2,280 |
| 16 | HEADACHE | 2,241 |
| 17 | EPILEPSY | 1,992 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Carbamazepine can cause severe skin reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be fatal. If you are of Asian descent, you may need a blood test before starting this medicine. Carbamazepine can also cause serious blood problems like aplastic anemia and agranulocytosis. Contact your doctor right away if you develop a fever, sore throat, rash, or unusual bleeding or bruising.
Known Drug Interactions
Anticonvulsants carbamazepine , phenobarbital, primidone, phenytoin ↓ nirmatrelvir/ritonavir Co-administration contraindicated due to potential loss of virologic response and possible resistance [see Contraindications (4) ] .
Mechanism: Carbamazepine makes your body get rid of the antiviral medicine too quickly, which prevents it from working against the virus.
CYP3A Inducers Do not use ranolazine with CYP3A inducers such as rifampin, rifabutin, rifapentine, phenobarbital, phenytoin, carbamazepine, and St.
Mechanism: Carbamazepine makes your body get rid of ranolazine too quickly, which prevents the medicine from working as it should.
7 DRUG INTERACTIONS Carbamazepine and other enzyme inducers decrease plasma concentrations of risperidone. ( 7.1 ) 7.1 Pharmacokinetic-related Interactions The dose of risperidone tablets should be adjusted when used in combination with CYP2D6 enzyme inhibitors (e.g., fluoxetine, and paroxetine) and enzyme inducers (e.g., carbamazepine) [see Table 18 and Dosage and Administration (2.5) ]. Do not exceed 8 mg/day 20 mg/day 4 mg/day 1.6 - 40 mg/day 4 mg/day 1.8 - Enzyme (CYP3A/ PgP inducers) Inducers Carbamazepine 573 ± 168 mg/day 3 mg twice daily 0.51 0.55 Titrate dose upwards.
Mechanism: Carbamazepine speeds up how fast your body breaks down risperidone, which lowers the amount of medicine in your blood.
Concomitant administration of carbamazepine and lithium may increase the risk of neurotoxic side effects.
Mechanism: Combining these two medications can increase the risk of toxic effects on your brain and nervous system.
7.2 Combined P-gp Strong CYP3A4 Inducers Avoid concomitant use of apixaban tablets with combined P-gp and strong CYP3A4 Inducers (e.g., rifampin, carbamazepine, phenytoin, St.
Mechanism: Carbamazepine makes your body break down apixaban too fast, which lowers the drug levels in your blood. This makes the medicine less effective at preventing dangerous blood clots.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I stop taking carbamazepine suddenly?
What should I do if I get a rash?
Can I drink alcohol while taking carbamazepine?
Does carbamazepine interact with other medications?
How often will I see the doctor while taking carbamazepine?
Can carbamazepine cure my condition?
What if I have trouble swallowing the tablets?
How long does it take for carbamazepine to start working?
Can I drive while taking carbamazepine?
What should I do if I experience side effects?
What are the common side effects of carbamazepine?
Does carbamazepine interact with other medications?
What drug class is carbamazepine?
Is there a generic version of carbamazepine?
What pregnancy or breastfeeding source fields are listed for carbamazepine?
Is carbamazepine currently in shortage?
Related Medications in Anticonvulsant
Other drugs grouped near carbamazepine - same-class peers and common alternatives.
brivaracetam
Briviact
Brivaracetam is a medicine used to treat partial-onset seizures.
Compare with carbamazepine →
cannabidiol
Epidiolex
Epidiolex is a medicine that contains cannabidiol.
Compare with carbamazepine →
cenobamate
Xcopri
Xcopri is a medicine used to treat partial-onset seizures in adults.
Compare with carbamazepine →
clobazam
Onfi, Sympazan
Clobazam oral suspension is a medicine used with other medicines to treat seizures caused by Lennox-Gastaut syndrome.
Compare with carbamazepine →
clonazepam
Klonopin
Clonazepam is a medicine that belongs to the benzodiazepine class.
Compare with carbamazepine →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for carbamazepine: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 65,260.
- duloxetine Δ 193 reports · Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) 65,067reports
- doxycycline Δ 772 reports · Tetracycline Antibiotic 64,488reports
- calcium carbonate Δ 856 reports · Calcium Supplement / Antacid 64,404reports
- fluoxetine Δ 1,141 reports · Selective Serotonin Reuptake Inhibitor (SSRI) 64,119reports
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 8.43%.
- albuterol Δ 0.00 pts · 113,967 reports · Short-Acting Beta-2 Agonist 8.43%death share
- ofloxacin Δ 0.02 pts · 7,063 reports · Fluoroquinolone Antibiotic 8.45%death share
- glimepiride Δ 0.03 pts · 37,936 reports · Sulfonylurea 8.40%death share
- cephalexin Δ 0.04 pts · 20,636 reports · First-Generation Cephalosporin 8.48%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for carbamazepine
The FDA label for carbamazepine (sold under brand names such as Tegretol) classifies it as a prescription-only medication in the Anticonvulsant class. Carbamazepine is used to treat certain types of seizures, including partial seizures and generalized tonic-clonic seizures. Official labeling lists 5 commonly reported side effects, including Dizziness, Drowsiness, Unsteadiness.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 65,260 voluntary reports. The database also lists 129 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.23 versus $0.41 for the brand - a 46% generic savings.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: February 18, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages