Prescription medicine
Warfarin Brand names: Jantoven; first approved as Coumadin
Warfarin (Coumadin) is a prescription medicine with an FDA approval on record since 1954. FDA's NDC Directory lists it from 19 generic labelers, and pharmacies paid $0.093 per warfarin sodium 2 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
- Boxed warning
Check it at the source: the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC); the NDA 9218 record on Drugs@FDA; every warfarin label on DailyMed.
Highlights of the record
FDA label of May 29, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
BLEEDING RISK.
Warfarin sodium can cause major or fatal bleeding [see Warnings and Precautions (5.1) ]. Perform regular monitoring of INR in all treated patients [see Dosage and Administration (2.1) ]. Drugs, dietary changes, and other factors affect INR levels achieved with warfarin sodium therapy [see Drug Interactions (7) ]. Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding [see Patient Counseling Information (17) ]. WARNING: BLEEDING RISK See full prescribing information for complete boxed warning. Warfarin sodium can cause major or fatal bleeding. (5.1) Perform regular monitoring of INR in all treated patients. (2.1) Drugs, dietary changes, and other factors affect INR levels achieved with warfarin sodium therapy. (7) Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding.
Used for
From the label: indications and usageWarfarin sodium tablets are indicated for: Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE).
Forms and strengths
- 1 mg
- 2 mg
- 2.5 mg
- 3 mg
- 4 mg
- 5 mg
- 6 mg
- 7.5 mg
- 10 mg
Tablet.
On the market
- Earliest approval on file
- June 8, 1954 Coumadin, Bristol Myers Squibb; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 10 first March 26, 1997; 6 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 19 of which 19 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.093 per tablet Warfarin sodium 2 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 7 since 2013 1 Class I among all firms' recalls; latest February 15, 2023
- FAERS reports
- 127,492 through July 30, 2026
What is warfarin used for?
From the label: indications and usageWarfarin sodium tablets are indicated for: Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE). Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) and/or cardiac valve replacement. Reduction in the risk of death, recurrent myocardial infarction (MI), and thromboembolic events such as stroke or systemic embolization after myocardial infarction. Limitations of Use Warfarin sodium tablets have no direct effect on an established thrombus, nor does it reverse ischemic tissue damage. […]
Conditions named in the indications of warfarin's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Vitamin K Antagonist.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
What does the patient leaflet for warfarin say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about warfarin sodium?Warfarin sodium can cause bleeding which can be serious and sometimes lead to death. This is because warfarin sodium is a blood thinner medicine that lowers the chance of blood clots forming in your body. You may have a higher risk of bleeding if you take warfarin sodium and: are 65 years of age or older have a history of stomach or intestinal bleeding have high blood pressure (hypertension) have a history of stroke, or “mini-stroke” (transient ischemic attack or TIA) have serious heart disease have a low blood count or cancer have had trauma, such as an accident or surgery have kidney problems take other medicines that increase your risk of bleeding, including: a medicine that contains heparin other medicines to prevent or treat blood clots nonsteroidal anti-inflammatory drugs (NSAIDs) take warfarin sodium for a long time. Warfarin sodium is the active ingredient in warfarin sodium tablets. Tell your healthcare provider if you take any of these medicines. […] Call your healthcare provider right away if you get any of the following signs or symptoms of bleeding problems: pain, swelling, or discomfort headaches, dizziness, or weakness unusual bruising (bruises that develop without known cause or grow in size) nosebleeds bleeding gums bleeding from cuts takes a long time to stop menstrual bleeding or vaginal bleeding that is heavier than normal pink or brown urine red or black stools coughing up blood vomiting blood or material that looks like coffee grounds Some foods and beverages can interact with warfarin sodium and affect your treatment and dose. Eat a normal, balanced diet. Talk to your healthcare provider before you make any diet changes. […]
From the patient leaflet: What should I avoid while taking warfarin sodium?Do not do any activity or sport that may cause a serious injury.
From the patient leaflet: How should I store warfarin sodium tablets?Store warfarin sodium tablets at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F). Keep warfarin sodium tablets in a tightly closed container. Keep warfarin sodium tablets out of the light and moisture. Follow your healthcare provider or pharmacist instructions about the right way to throw away outdated or unused warfarin sodium. Females who are pregnant should not handle crushed or broken warfarin sodium tablets. Keep warfarin sodium tablets and all medicines out of the reach of children.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
Is there a generic for warfarin (Coumadin)?
The FDA approved the first generic warfarin on March 26, 1997. 10 generic applications are approved; 6 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists warfarin from 19 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1954 earliest approval on file
- 1997 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for warfarin (Coumadin)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.093 per Warfarin sodium 2 mg tablet, up 2% from $0.0912 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Warfarin sodium 5 mg tablet (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Jantoven 1 mg tablet | Generic | $0.0986 per tablet | $2.96 | +16% |
| Jantoven 10 mg tablet | Generic | $0.106 per tablet | $3.19 | -0.5% |
| Jantoven 2 mg tablet | Generic | $0.093 per tablet | $2.79 | +2% |
| Jantoven 2.5 mg tablet | Generic | $0.0961 per tablet | $2.88 | +4% |
| Jantoven 3 mg tablet | Generic | $0.0986 per tablet | $2.96 | +2% |
| Jantoven 4 mg tablet | Generic | $0.0956 per tablet | $2.87 | +5% |
| Jantoven 5 mg tablet | Generic | $0.0888 per tablet | $2.66 | -11% |
| Jantoven 6 mg tablet | Generic | $0.0981 per tablet | $2.94 | -9% |
| Jantoven 7.5 mg tablet | Generic | $0.0891 per tablet | $2.67 | -16% |
| Warfarin sodium 1 mg tablet | Generic | $0.0986 per tablet | $2.96 | +16% |
| Warfarin sodium 10 mg tablet | Generic | $0.106 per tablet | $3.19 | -0.5% |
| Warfarin sodium 2 mg tablet | Generic | $0.093 per tablet | $2.79 | +2% |
| Warfarin sodium 2.5 mg tablet | Generic | $0.0961 per tablet | $2.88 | +4% |
| Warfarin sodium 3 mg tablet | Generic | $0.0986 per tablet | $2.96 | +2% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has warfarin been recalled?
The FDA's Enforcement Report lists 7 recalls naming warfarin since 2013: 1 Class I (the most serious), 5 Class II, 1 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| February 15, 2023 | Class II | RISING PHARMACEUTICALS | Failed Impurities/Degradation Specifications |
| January 26, 2022 | Class II | CARDINAL HEALTHCARE | CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions. |
| August 25, 2014 | Class III | Taro Pharmaceuticals U.S.A., Inc. | Failed Content Uniformity Specifications. |
| July 2, 2013 | Class II | Aidapak Services, LLC | Labeling: Label Mixup; WARFARIN SODIUM, Tablet, 0.5 mg (1/2 of 1 mg) may be potentially mislabeled as SODIUM CHLORIDE, Tablet, 1 mg, NDC 00223176001, Pedigree … |
| July 2, 2013 | Class II | Aidapak Services, LLC | Labeling: Label Mixup; WARFARIN SODIUM Tablet, 0.5 mg (1/2 of 1 mg) may be potentially mislabeled as SODIUM CHLORIDE, Tablet, 1 mg, NDC 00223176001, Pedigree … |
| May 13, 2013 | Class I | Zydus Pharmaceuticals USA Inc | Failed Tablet/Capsule Specifications: A product complaint was received from a pharmacist who discovered that 3 tablets in a 1000-count bottle were oversized. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the warfarin label say about other medicines?
The warfarin label names 95 other medicines in its interaction, contraindication or warning sections. The labels of 35 other medicines name warfarin. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Acyclovir | drug interactions | … tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone … |
| Allopurinol | drug interactions | … tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone … |
| Alprazolam | drug interactions | … verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir … |
| Amiodarone | drug interactions | Closely monitor INR if a concomitant drug is a CYP2C9, 1A2, and/or 3A4 inhibitor or inducer. Examples of CYP450 Interactions with Warfarin Enzyme Inhibitors Inducers CYP2C9 amiodarone, capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone … |
| Amlodipine | drug interactions | … montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin … |
| Aprepitant | drug interactions | … fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine … |
| Argatroban | drug interactions | Drug Class: Anticoagulants; Specific Drugs: argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin |
| Armodafinil | drug interactions | … posaconazole, ranitidine, ranolazine, ritonavir, saquinavir, telithromycin, tipranavir, voriconazole, zileuton armodafinil, amprenavir, aprepitant, bosentan, carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide |
| Aspirin | drug interactions | Drug Class: Antiplatelet Agents; Specific Drugs: aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine |
| Atazanavir | drug interactions | … phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir … |
| Atorvastatin | drug interactions | … phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine … |
| Bicalutamide | drug interactions | … cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib … |
| Bivalirudin | drug interactions | Drug Class: Anticoagulants; Specific Drugs: argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin |
| Bosentan | drug interactions | … metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral … |
Every other medicine the warfarin label names
| Medicine named | Section | What the label says |
|---|---|---|
| Caffeine | drug interactions | … carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral … |
| Capecitabine | drug interactions | … Interactions with Warfarin Enzyme Inhibitors Inducers CYP2C9 amiodarone, capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone … |
| Carbamazepine | drug interactions | … sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram … |
| Celecoxib | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Cilostazol | drug interactions | … amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem … |
| Cimetidine | drug interactions | … carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral … |
| Ciprofloxacin | drug interactions | … phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives … |
| Citalopram | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Clarithromycin | drug interactions | … atorvastatin, atazanavir, bicalutamide, cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine … |
| Clopidogrel | drug interactions | Drug Class: Antiplatelet Agents; Specific Drugs: aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine |
| Cyclosporine | drug interactions | … cilostazol, cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib … |
| Dabigatran | drug interactions | Drug Class: Anticoagulants; Specific Drugs: argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin |
| Darunavir | drug interactions | … cimetidine, ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid … |
| Desvenlafaxine | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Diclofenac | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Diflunisal | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Diltiazem | drug interactions | … ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid … |
| Dipyridamole | drug interactions | Drug Class: Antiplatelet Agents; Specific Drugs: aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine |
| Disulfiram | drug interactions | … CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine … |
| Duloxetine | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Efavirenz | drug interactions | … zileuton armodafinil, amprenavir, aprepitant, bosentan, carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide |
| Erythromycin | drug interactions | … clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole … |
| Escitalopram | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Etravirine | drug interactions | … Inhibitors Inducers CYP2C9 amiodarone, capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline … |
| Famotidine | drug interactions | … allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone … |
| Fenoprofen | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Fluconazole | drug interactions | … Inducers CYP2C9 amiodarone, capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole … |
| Fluoxetine | drug interactions | … cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir … |
| Fluvastatin | drug interactions | … amiodarone, capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant … |
| Fluvoxamine | drug interactions | … capecitabine, cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan … |
| Fosamprenavir | drug interactions | … darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone … |
| Heparin | drug interactions | Drug Class: Anticoagulants; Specific Drugs: argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin |
| Ibuprofen | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Imatinib | drug interactions | … erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral … |
| Indomethacin | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Isoniazid | drug interactions | … fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives … |
| Itraconazole | drug interactions | … fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole … |
| Ketoconazole | drug interactions | … fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine … |
| Ketoprofen | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Ketorolac | drug interactions | Drug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin … |
| Lopinavir and ritonavir | drug interactions | Closely monitor INR if a concomitant drug is a CYP2C9, 1A2, and/or 3A4 inhibitor or inducer. Examples of CYP450 Interactions with Warfarin Enzyme Inhibitors Inducers CYP2C9 amiodarone, capecitabine … |
| Mefenamic acid | drug interactions | … diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac |
| Methoxsalen | drug interactions | … cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine … |
| Metronidazole | drug interactions | … cotrimoxazole, etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine … |
| Mexiletine | drug interactions | … ciprofloxacin, disulfiram, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine, thiabendazole … |
| Miconazole | drug interactions | … etravirine, fluconazole, fluvastatin, fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital … |
| Milnacipran | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Modafinil | drug interactions | … ritonavir, saquinavir, telithromycin, tipranavir, voriconazole, zileuton armodafinil, amprenavir, aprepitant, bosentan, carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenytoin … |
| Montelukast | drug interactions | … propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine … |
| Nafcillin | drug interactions | … aprepitant, bosentan, carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide |
| Naproxen | drug interactions | … fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac |
| Nefazodone | drug interactions | … indinavir, isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine, ranolazine, ritonavir, saquinavir … |
| Nelfinavir | drug interactions | … isoniazid, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine, ranolazine, ritonavir, saquinavir, telithromycin … |
| Nilotinib | drug interactions | … itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine, ranolazine, ritonavir, saquinavir, telithromycin, tipranavir … |
| Omeprazole | drug interactions | … thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant … |
| Oxaprozin | drug interactions | … ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac |
| Paroxetine | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Phenobarbital | drug interactions | … tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin … |
| Phenytoin | drug interactions | … verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone, amlodipine, amprenavir, aprepitant, atorvastatin, atazanavir … |
| Pioglitazone | drug interactions | … carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide |
| Piroxicam | drug interactions | … indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac |
| Posaconazole | drug interactions | … lopinavir/ritonavir, nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine, ranolazine, ritonavir, saquinavir, telithromycin, tipranavir, voriconazole, zileuton … |
| Prasugrel | drug interactions | Drug Class: Antiplatelet Agents; Specific Drugs: aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine |
| Prednisone | drug interactions | … efavirenz, etravirine, modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide |
| Propafenone | drug interactions | … mexiletine, norfloxacin, oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole … |
| Propranolol | drug interactions | … norfloxacin, oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital … |
| Ranitidine | drug interactions | … nefazodone, nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine, ranolazine, ritonavir, saquinavir, telithromycin, tipranavir, voriconazole, zileuton armodafinil, amprenavir … |
| Ranolazine | drug interactions | … nelfinavir, nilotinib, oral contraceptives, posaconazole, ranitidine, ranolazine, ritonavir, saquinavir, telithromycin, tipranavir, voriconazole, zileuton armodafinil, amprenavir, aprepitant … |
| Rifampin | drug interactions | … voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine, ciprofloxacin, disulfiram, enoxacin, famotidine … |
| Ritonavir | drug interactions | … ciprofloxacin, clarithromycin, conivaptan, cyclosporine, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fluoxetine, fluvoxamine, fosamprenavir, imatinib, indinavir, isoniazid … |
| Rufinamide | drug interactions | … modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide |
| Sertraline | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Sulindac | drug interactions | … ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac |
| Terbinafine | drug interactions | … oral contraceptives, phenylpropanolamine, propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin … |
| Tigecycline | drug interactions | … fluvoxamine, metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol … |
| Venlafaxine | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Verapamil | drug interactions | … propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone … |
| Vilazodone | drug interactions | Drug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone |
| Voriconazole | drug interactions | … metronidazole, miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine … |
| Zafirlukast | drug interactions | … miconazole, oxandrolone, sulfinpyrazone, tigecycline, voriconazole, zafirlukast aprepitant, bosentan, carbamazepine, phenobarbital, rifampin CYP1A2 acyclovir, allopurinol, caffeine, cimetidine … |
| Zileuton | drug interactions | … propafenone, propranolol, terbinafine, thiabendazole, ticlopidine, verapamil, zileuton montelukast, moricizine, omeprazole, phenobarbital, phenytoin, cigarette smoking CYP3A4 alprazolam, amiodarone … |
Other labels that name warfarin
- Acetaminophen
- Adalimumab
- Alpha-tocopherol, asorbic acid and 11 other ingredients
- Alprostadil
- Alteplase
- Apixaban
- Ascorbic acid
- Aspirin and dipyridamole
- Aspirin and oxycodone
- Aspirin, butalbital, caffeine and codeine
- Atovaquone and proguanil
- Avutometinib and defactinib
- Azathioprine
- Betaxolol
- Bimekizumab
- Blinatumomab
- Brodalumab
- Canakinumab
- Carbidopa and entacapone and levodopa
- Cefixime
- Ceritinib
- Cholestyramine
- Clomipramine
- Cobicistat, elvitegravir, emtricitabine and tenofovir alafenamide
- Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil
- Colesevelam
- Colestipol
- Cyclophosphamide
- Dabrafenib
- Danazol
- Dantrolene
- Dasiglucagon
- Deutivacaftor and tezacaftor and vanzacaftor
- Dexlansoprazole
- Dextran 40
- Dicloxacillin
- Divalproex
- Dronabinol
- Dronedarone
- Dulaglutide
- Econazole
- Edoxaban
- Elbasvir and grazoprevir
- Enzalutamide
- Erlotinib
- Esomeprazole
- Etodolac
- Etoposide
- Exenatide
- Ferric oxyhydroxide
- Fluorouracil
- Flutamide
- Fosaprepitant
- Gefitinib
- Gemfibrozil
- Glucagon
- Golimumab
- Hydrocortisone
- Icosapent
- Infliximab
- Ivacaftor
- Ivermectin
- Lansoprazole
- Ledipasvir and sofosbuvir
- Leflunomide
- Lenalidomide
- Letermovir
- Levocarnitine
- Levomilnacipran
- Lomitapide
- Meclofenamate
- Meloxicam
- Melphalan
- Mercaptopurine
- Methimazole
- Metreleptin
- Mifepristone
- Mirtazapine
- Mitotane
- Moxifloxacin
- Multiple vitamins
- Nabumetone
- Nevirapine
- Nitazoxanide
- Nitisinone
- Ofloxacin
- Oritavancin
- Orlistat
- Pantoprazole
- Pentobarbital
- Propylthiouracil
- Quinidine
- Quinine
- Rabeprazole
- Raloxifene
- Regorafenib
- Rifaximin
- Rilonacept
- Rivaroxaban
- Rolapitant
- Romidepsin
- Rosuvastatin
- Rucaparib camsylate
- Sarilumab
- Siltuximab
- Simvastatin
- Sofosbuvir and velpatasvir
- Sofosbuvir and velpatasvir and voxilaprevir
- Sorafenib
- Sulfamethoxazole and trimethoprim
- Tamoxifen
- Tamsulosin
- Tenecteplase
- Teriflunomide
- Teriparatide
- Testosterone
- Tinidazole
- Tirzepatide
- Tocilizumab
- Toremifene
- Tramadol
- Trazodone
- Valproic acid
- Varenicline
- Venetoclax
- Vortioxetine
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
What do FAERS reports show for warfarin?
The FDA Adverse Event Reporting System holds 127,492 reports that list warfarin among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 16,218 are coded as a death and 58,202 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as warfarin?
4 other medicines are given the same way (oral) and in the same FDA class as warfarin or labeled mainly for the same use (blood clots (DVT and PE)), the same class first. Blood clots (DVT and PE) lists all 12 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Dabigatran | Atrial fibrillation, Blood clots (DVT and PE) | 16 labelers | $0.795 per capsule 150 mg capsule | No current entry |
| Rivaroxaban | Atrial fibrillation, Blood clots (DVT and PE) | 20 labelers | $0.650 per tablet 2.5 mg tablet | A presentation being discontinued |
| Apixaban | Atrial fibrillation, Blood clots (DVT and PE) | 2 labelers | $5.52 per tablet 5 mg tablet | No current entry |
| Edoxaban | Atrial fibrillation, Blood clots (DVT and PE) | none listed | $15.51 per tablet 60 mg tablet | No current entry |
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does warfarin compare with medicines for the same use?
4 side-by-side pages set warfarin beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to warfarin
- 4 medicines for the same use
- Warfarin side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other