dulaglutide
Brand names: Trulicity
Trulicity is a medicine to help control blood sugar in people with type 2 diabetes. It can also lower the risk of heart problems in adults with both type 2 diabetes and heart disease or heart risk factors.
Drug Pricing (NADAC)
Brand Price
$471.69/unit
Generic Available
No
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Trulicity helps adults and children 10 years and older manage their type 2 diabetes.
Common side effects
Nausea, Diarrhea, Vomiting
Key warnings
Trulicity may cause thyroid tumors, including a type of thyroid cancer called medullary thyroid carcinoma (MTC).
How It Works
Trulicity is a GLP-1 receptor agonist. It mimics a natural hormone in your body. This helps your body release insulin when your blood sugar is high and lowers the amount of sugar your liver makes.
How to Take It
You will inject Trulicity under your skin once a week. You can inject it any time of day, with or without food. Inject it in your stomach area, thigh, or upper arm. Be sure to change your injection site each week.
Pregnancy & Breastfeeding
There is not enough information about Trulicity in pregnant women to know if it will harm an unborn baby. Trulicity should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Talk to your doctor if you are pregnant or plan to become pregnant.
Missed Dose
If you miss a dose, take it as soon as you remember if there are at least 3 days (72 hours) until your next scheduled dose. If less than 3 days remain, skip the missed dose and take your next dose on your regularly scheduled day.
Storage
Store Trulicity in the refrigerator between 36°F to 46°F (2°C to 8°C).
Side Effects (from patient reports)
Based on 59,969 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 85,635 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2011–2025.
Total Reports
85,635
Death-Related Reports
1,580
Hospitalization Reports
10,007
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | NAUSEA | 9,986 |
| 2 | INJECTION SITE PAIN | 9,796 |
| 3 | BLOOD GLUCOSE INCREASED | 9,762 |
| 4 | DIARRHOEA | 5,737 |
| 5 | INCORRECT DOSE ADMINISTERED | 5,444 |
| 6 | VOMITING | 5,413 |
| 7 | INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION | 3,806 |
| 8 | DRUG INEFFECTIVE | 3,523 |
| 9 | WEIGHT DECREASED | 3,349 |
| 10 | DECREASED APPETITE | 3,153 |
| 11 | INJECTION SITE HAEMORRHAGE | 3,132 |
| 12 | EXTRA DOSE ADMINISTERED | 3,106 |
| 13 | GLYCOSYLATED HAEMOGLOBIN INCREASED | 2,906 |
| 14 | FATIGUE | 2,409 |
| 15 | ACCIDENTAL UNDERDOSE | 2,354 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Trulicity may cause thyroid tumors, including a type of thyroid cancer called medullary thyroid carcinoma (MTC). You should not use Trulicity if you or your family have ever had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your doctor if you have a lump in your neck, trouble swallowing, trouble breathing, or a hoarse voice that doesn't go away.
Known Drug Interactions
Monitor drug levels of oral medications with a narrow therapeutic index (e.g., warfarin) when concomitantly administered with TRULICITY.
Mechanism: Dulaglutide can affect how your body absorbs other pills, which can be risky for drugs like warfarin that need to stay at a very specific level to work safely.
What to do: Your doctor should monitor your blood work closely to ensure your warfarin dose stays in the safe range.
Common Questions
What should I do if I experience severe stomach pain?
Can Trulicity cause low blood sugar?
What are the symptoms of a serious allergic reaction?
Can Trulicity affect my kidneys?
What if I have severe stomach problems?
Can Trulicity affect my eyes if I have diabetic retinopathy?
What if I think I have gallbladder problems?
Does Trulicity interact with other medications?
How will I know if Trulicity is working?
What if the Trulicity solution looks cloudy or has particles in it?
What are the common side effects of dulaglutide?
Does dulaglutide interact with other medications?
What drug class is dulaglutide?
Is dulaglutide safe during pregnancy?
Related Medications in GLP-1 Receptor Agonist
Other drugs grouped near dulaglutide — same-class peers and common alternatives.
acarbose
Precose
Acarbose is a medicine that helps lower blood sugar levels in people with type 2 diabetes.
Compare with dulaglutide →
alogliptin
Nesina
Alogliptin and Metformin HCl is a drug that helps lower blood sugar in adults with type 2 diabetes.
Compare with dulaglutide →
bromocriptine
Cycloset
Bromocriptine (Cycloset) is a medicine that acts like dopamine in your body.
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canagliflozin
Invokana
Invokana is a medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes.
Compare with dulaglutide →
colesevelam
Welchol
Colesevelam is a medicine that helps lower bad cholesterol (LDL-C) and control blood sugar in adults.
Compare with dulaglutide →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Related Health & Safety Data
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💉 Procedure Costs
Medicare procedure pricing for 9,297 procedures
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What the FDA Data Shows for dulaglutide
The FDA label for dulaglutide (sold under brand names such as Trulicity) classifies it as a prescription-only medication in the GLP-1 Receptor Agonist class. Trulicity helps adults and children 10 years and older manage their type 2 diabetes. Official labeling lists 5 commonly reported side effects, including Nausea, Diarrhea, Vomiting.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 59,969 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: August 5, 2023
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages