Skip to main content

Prescription medicine

Atezolizumab and hyaluronidase Brand names: Tecentriq

Atezolizumab and hyaluronidase (Tecentriq) is a prescription medicine. No generic is listed in FDA's NDC Directory.

  • No generic listed

Check it at the source: the atezolizumab and hyaluronidase FDA label on DailyMed (effective May 20, 2026); every atezolizumab and hyaluronidase label on DailyMed.

Highlights of the record

FDA label of May 20, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026

Used for

From the label: indications and usage

TECENTRIQ HYBREZA is a combination of atezolizumab, a programmed death-ligand 1 (PD-L1) blocking antibody, and hyaluronidase, an endoglycosidase indicated: Non-Small Cell Lung Cancer (NSCLC) as adjuvant treatment following resection and platinum-based chemotherapy for adult patients with Stage II to IIIA NSCLC whose tumors have PD-L1 expression on ≥ 1% of tumor cells, as determined by an FDA-authorized test.

Forms and strengths

  • 1875 mg/15ml / 15ml

Injection.

On the market

Generic approvals
No generic approved
Labelers listed (NDC)
1 of which 0 under generic applications, 1 under brand applications, repackagers included

Supply and safety

Pharmacy cost (NADAC)
Not in the survey
Shortage (FDA)
No current entry
Recalls by its makers (FDA)
No recall recorded

What is atezolizumab and hyaluronidase used for?

From the label: indications and usage

TECENTRIQ HYBREZA is a combination of atezolizumab, a programmed death-ligand 1 (PD-L1) blocking antibody, and hyaluronidase, an endoglycosidase indicated: Non-Small Cell Lung Cancer (NSCLC) as adjuvant treatment following resection and platinum-based chemotherapy for adult patients with Stage II to IIIA NSCLC whose tumors have PD-L1 expression on ≥ 1% of tumor cells, as determined by an FDA-authorized test. […]

Conditions named in the indications of atezolizumab and hyaluronidase's FDA labels, with every medicine labeled for each:

FDA pharmacologic class: Endoglycosidase and Programmed Death Receptor-1 Blocking Antibody.

Source: FDA drug label (Tecentriq Hybreza), Genentech, Inc., effective May 20, 2026 (SPL set a617b089-ce66-464b-987b-b45d029b4d6f), via openFDA; the full label on DailyMed

What does the patient leaflet for atezolizumab and hyaluronidase say first?

The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.

From the patient leaflet: What is the most important information I should know about TECENTRIQ HYBREZA?

TECENTRIQ HYBREZA is a medicine that may treat certain cancers by working with your immune system. TECENTRIQ HYBREZA can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during your treatment or even after your treatment has ended. […] These are not all of the signs and symptoms of immune system problems that can happen with TECENTRIQ HYBREZA. Call or see your healthcare provider right away for any new or worsening signs or symptoms, including: chest pain, irregular heartbeat, shortness of breath, swelling of ankles confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight persistent or severe muscle pain or weakness, muscle cramps low red blood cells, bruising Infusion reactions that can sometimes be severe or life-threatening. […]

Source: FDA drug label (Tecentriq Hybreza), Genentech, Inc., effective May 20, 2026 (SPL set a617b089-ce66-464b-987b-b45d029b4d6f), via openFDA; the full label on DailyMed

Is there a generic for atezolizumab and hyaluronidase (Tecentriq)?

No generic atezolizumab and hyaluronidase is approved (Drugs@FDA, October 8, 2026).

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What does the atezolizumab and hyaluronidase label say about other medicines?

The atezolizumab and hyaluronidase label names 3 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Medicine namedSectionWhat the label says
Cobimetinibwarnings and precautionsIntravenous Atezolizumab in Combination with Cobimetinib and Vemurafenib: Immune-mediated pneumonitis occurred in 13% (29/230) of patients receiving intravenous atezolizumab in combination with cobimetinib and vemurafenib in the IMspire150 trial [see Adverse Reactions (6.1) ], including Grade 3 (1.3%) and Grade 2 (7%) …
Prednisonewarnings and precautionsIn general, if TECENTRIQ HYBREZA requires interruption or discontinuation, administer systemic corticosteroid therapy (1 to 2 mg/kg/day prednisone or equivalent) until improvement to Grade 1 or less.
Vemurafenibwarnings and precautionsIntravenous Atezolizumab in Combination with Cobimetinib and Vemurafenib: Immune-mediated pneumonitis occurred in 13% (29/230) of patients receiving intravenous atezolizumab in combination with cobimetinib and vemurafenib in the IMspire150 trial [see Adverse Reactions (6.1) ], including Grade 3 (1.3%) and Grade 2 (7%) …

Check atezolizumab and hyaluronidase against other medicines

Source: FDA drug label (Tecentriq Hybreza), Genentech, Inc., effective May 20, 2026 (SPL set a617b089-ce66-464b-987b-b45d029b4d6f), via openFDA; the full label on DailyMed

What else is labeled for the same conditions as atezolizumab and hyaluronidase?

1 other medicine is given the same way (subcutaneous) and in the same FDA class as atezolizumab and hyaluronidase or labeled mainly for the same use (lung cancer), the same class first. Lung cancer lists all 55 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

MedicineShared indicationGeneric labelers (subcutaneous)Pharmacy costShortage
Berahyaluronidase alfa and pembrolizumabLung cancernone listedn/aNo current entry

Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)

What next?

Other endoglycosidases
the pharmacologic class, with prices and generics
Check an interaction
what two or more labels say about each other