Prescription medication · Triple Therapy (ICS/LAMA/LABA)

fluticasone/umeclidinium/vilanterol

Also sold as Trelegy Ellipta. Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better.

Data updated 2026-05-15

2
InteractionsFew interactions
$10.50
Brand price (NADAC)

fluticasone/umeclidinium/vilanterol (Trelegy Ellipta) is a prescription Triple Therapy (ICS/LAMA/LABA). Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better.

Trelegy Ellipta is a medicine that contains three drugs in one inhaler. It helps people with COPD and asthma breathe easier.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Brand Price

$10.50/unit

Generic Available

No

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

Compare with Another Drug →

What it does

Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better.

Common side effects

Upper respiratory infection, Pneumonia, Bronchitis

Key warnings

LABA medicines like vilanterol can raise the risk of asthma-related problems.

The sections below are summarized in plain English from fluticasone/umeclidinium/vilanterol's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Trelegy Ellipta contains three medicines that work in different ways. Fluticasone reduces swelling in the lungs. Umeclidinium and vilanterol relax the muscles around your airways, making it easier to breathe.

Serious Warnings

LABA medicines like vilanterol can raise the risk of asthma-related problems. Do not use Trelegy Ellipta for sudden, severe COPD or asthma symptoms. Rinse your mouth after use to prevent thrush. Trelegy Ellipta may increase your risk of pneumonia. It can also weaken your immune system and raise your risk of infections. It may cause problems with your heart, blood pressure, blood sugar, or bones. Long-term use may lead to glaucoma or cataracts. Tell your doctor if your glaucoma or urinary retention gets worse.

Known Drug Interactions

moderate ketoconazole

7 DRUG INTERACTIONS • Strong cytochrome P450 3A4 inhibitors (e.g., ketoconazole): Use with caution. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol. Caution should be exercised when considering the coadministration of TRELEGY ELLIPTA with ketoconazole and other known strong CYP3A4 inhibitors [see Warnings and Precautions ( 5.9 ), Clinical Pharmacology ( 12.3 )] .

Mechanism: Ketoconazole blocks the enzyme that clears the inhaler's ingredients from your system, causing the drug levels to rise.

minor fluticasone

( 7.5 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone furoate and vilanterol are substrates of CYP3A4. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol.

Mechanism: Both of these medications contain the same steroid ingredient. Taking them together increases the total amount of medicine in your body, which can lead to more side effects.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

What should I do if I have trouble breathing between doses?
Use a rescue inhaler like albuterol for quick relief.
Can I use Trelegy Ellipta for a sudden asthma attack?
No, Trelegy Ellipta is not a rescue medicine. Use a short-acting beta2-agonist (like albuterol) for acute symptoms.
Will Trelegy Ellipta cure my COPD or asthma?
No, Trelegy Ellipta helps manage your symptoms. It is a maintenance treatment.
Can I stop taking my other asthma medicines when I start Trelegy Ellipta?
Talk to your doctor before stopping any medicines.
Does Trelegy Ellipta contain steroids?
Yes, it contains fluticasone furoate, which is an inhaled corticosteroid (ICS).
Can I use a spacer with Trelegy Ellipta?
No, Trelegy Ellipta is designed to be used without a spacer.
What if I get a white coating in my mouth?
This could be thrush. Rinse your mouth with water after each dose to help prevent it. Contact your doctor if it develops.
Can I use Trelegy Ellipta if I am allergic to milk?
You should not use Trelegy Ellipta if you have a severe milk allergy.
How long after opening the foil tray is Trelegy Ellipta good for?
Discard Trelegy Ellipta 6 weeks after opening the foil tray or when the counter reads “0”, whichever comes first.
What should I do if I accidentally take two doses in one day?
Contact your doctor for guidance.
What are the common side effects of fluticasone/umeclidinium/vilanterol?
The registry lists Upper respiratory infection, Pneumonia, Bronchitis, Oral thrush (Candida), Headache among the most-reported FAERS reaction terms for fluticasone/umeclidinium/vilanterol. These counts are not an individual symptom assessment.
Does fluticasone/umeclidinium/vilanterol interact with other medications?
The registry has 2 documented interaction rows for fluticasone/umeclidinium/vilanterol. Notable source-record pairings include ketoconazole, fluticasone. These rows are not a complete medication review.
What drug class is fluticasone/umeclidinium/vilanterol?
fluticasone/umeclidinium/vilanterol belongs to the Triple Therapy (ICS/LAMA/LABA) drug class. It requires a prescription (Rx). Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better.
What pregnancy or breastfeeding source fields are listed for fluticasone/umeclidinium/vilanterol?
The FDA label for fluticasone/umeclidinium/vilanterol contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in Triple Therapy (ICS/LAMA/LABA)

Other drugs grouped near fluticasone/umeclidinium/vilanterol - same-class peers and common alternatives.

aclidinium

Tudorza Pressair

Compare with fluticasone/umeclidinium/vilanterol →

albuterol

Ventolin, ProAir

Albuterol is a drug that helps you breathe easier.

Compare with fluticasone/umeclidinium/vilanterol →

albuterol/ipratropium

Combivent Respimat, DuoNeb

Combivent Respimat is a combination medicine that helps open your airways.

Compare with fluticasone/umeclidinium/vilanterol →

beclomethasone

Qvar

Qvar Redihaler is an inhaled medicine that helps control asthma symptoms.

Compare with fluticasone/umeclidinium/vilanterol →

benralizumab

Fasenra

Fasenra is a medicine that can help treat severe asthma and EGPA.

Compare with fluticasone/umeclidinium/vilanterol →

Compare fluticasone/umeclidinium/vilanterol vs aclidinium side-by-side →

Medication Guides

Understanding Drug Interactions

How CYP450 enzymes, inhibitors, and inducers affect your medications

Generic vs Brand Name Drugs

FDA requirements, cost savings, and when the difference matters

Narrow Therapeutic Index Drugs

FDA bioequivalence and label-record context for narrow therapeutic index medicines

Common Drug Interactions

Dangerous medication combinations and how to protect yourself

Save on fluticasone/umeclidinium/vilanterol

Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.

Check Prices on GoodRx →

Disclosure: This link may earn us a commission at no extra cost to you. See our terms.

What the FDA Data Shows for fluticasone/umeclidinium/vilanterol

The FDA label for fluticasone/umeclidinium/vilanterol (sold under brand names such as Trelegy Ellipta) classifies it as a prescription-only medication in the Triple Therapy (ICS/LAMA/LABA) class. Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better. Official labeling lists 19 commonly reported side effects, including Upper respiratory infection, Pneumonia, Bronchitis.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: June 2, 2023

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page