Prescription medication · 5-HT3 Receptor Antagonist (Antiemetic)
granisetron
Also sold as Kytril. Granisetron is used to prevent nausea and vomiting.
Data updated 2026-05-15
- 10,198
- FDA reportsModerately reported
- 3
- InteractionsFew interactions
- $1.39
- Generic price (NADAC)
What the data shows
granisetron (Kytril) is a prescription 5-HT3 Receptor Antagonist (Antiemetic), reported less often than most tracked drugs (10,198 FDA reports), with 3 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
granisetron (Kytril) is a prescription 5-HT3 Receptor Antagonist (Antiemetic). Granisetron is used to prevent nausea and vomiting.
Granisetron oral solution helps prevent nausea and vomiting caused by cancer treatments like chemotherapy and radiation. It belongs to a class of drugs called 5-HT3 receptor antagonists.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$1.39/unit
Generic Available
Yes (8 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: GRANISETRON HCL 1 MG TABLET
Same CMS presentation as the headline generic unit price above (2 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: +21.2% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| August 21, 2024 | $1.15/EA | - | 2 |
| December 18, 2024 | $1.39/EA | +21.2% | 6 |
What it does
Granisetron is used to prevent nausea and vomiting.
Common side effects
Headache, Constipation, Weakness or fatigue
Key warnings
Granisetron can cause a heart problem called QT prolongation.
The sections below are summarized in plain English from granisetron's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Granisetron blocks a natural substance called serotonin in the body. Serotonin can trigger nausea and vomiting. By blocking serotonin, granisetron helps prevent these side effects.
Side Effects (from patient reports)
Based on 10,198 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for granisetron, by number of reports
- Nausea
Nausea
1,305 reports
- Vomiting
Vomiting
754 reports
- Febrile Neutropenia
Febrile Neutropenia
718 reports
- Diarrhoea
Diarrhoea
709 reports
- Pyrexia
Pyrexia
641 reports
- Death
Death
603 reports
- Dyspnoea
Dyspnoea
592 reports
- Fatigue
Fatigue
549 reports
- Neutropenia 474
Neutropenia
474 reports
- Anaemia 469
Anaemia
469 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for granisetron each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where granisetron sits
granisetron has more FDA adverse-event reports than 40% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is granisetron; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 10,198 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2003–2025.
Total Reports
10,198
Reports Mentioning Death
1,855
18.2% of reports — not proof of cause
Hospitalization Reports
4,892
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | NAUSEA | 1,305 |
| 2 | VOMITING | 754 |
| 3 | FEBRILE NEUTROPENIA | 718 |
| 4 | DIARRHOEA | 709 |
| 5 | PYREXIA | 641 |
| 6 | DEATH | 603 |
| 7 | DYSPNOEA | 592 |
| 8 | FATIGUE | 549 |
| 9 | NEUTROPENIA | 474 |
| 10 | ANAEMIA | 469 |
| 12 | PRODUCT ADHESION ISSUE | 399 |
| 13 | CONSTIPATION | 393 |
| 14 | DECREASED APPETITE | 368 |
| 15 | PNEUMONIA | 363 |
| 16 | GENERAL PHYSICAL HEALTH DETERIORATION | 343 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Granisetron can cause a heart problem called QT prolongation. Tell your doctor if you take other medicines that can also cause this issue, as it could lead to serious heart problems.
Known Drug Interactions
In in vitro human microsomal studies, ketoconazole inhibited ring oxidation of granisetron. However, the clinical significance of in vivo pharmacokinetic interactions with ketoconazole is not known.
Mechanism: Ketoconazole might slow down how your liver processes granisetron, but doctors are not sure if this causes any real problems.
In a human pharmacokinetic study, hepatic enzyme induction with phenobarbital resulted in a 25% increase in total plasma clearance of intravenous granisetron.
Mechanism: Phenobarbital makes your liver work faster to remove granisetron from your body.
Intervention No dosage adjustment needed Examples ondansetron, granisetron, dolasetron 7.2 Effect of Other Drugs on the Pharmacokinetics of Aprepitant Aprepitant is a CYP3A4 substrate [see Clinical Pharmacology ( 12.3 )] . Intervention No dosage adjustment needed Examples ondansetron, granisetron, dolasetron 7.2 Effect of Other Drugs on the Pharmacokinetics of Aprepitant Aprepitant is a CYP3A4 substrate [see Clinical Pharmacology ( 12.3 )] .
Mechanism: These medicines do not significantly change how the body handles either drug.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take granisetron every day?
Does granisetron interact with other medications?
What should I do if I experience side effects?
Can children take granisetron?
Do I need to adjust the dose if I have kidney or liver problems?
Can I drink alcohol while taking granisetron?
What does granisetron oral solution look like?
What if I accidentally take too much granisetron?
How long does granisetron take to work?
Can I drive or operate machinery while taking granisetron?
What are the common side effects of granisetron?
Does granisetron interact with other medications?
What drug class is granisetron?
What pregnancy or breastfeeding source fields are listed for granisetron?
Related Medications in 5-HT3 Receptor Antagonist (Antiemetic)
Other drugs grouped near granisetron - same-class peers and common alternatives.
alosetron
Lotronex
Alosetron (Lotronex) is a medicine for women with severe diarrhea-predominant irritable bowel syndrome (IBS).
Compare with granisetron →
aprepitant
Emend
Aprepitant (Emend) is a medicine that helps prevent nausea and vomiting.
Compare with granisetron →
bisacodyl
Dulcolax
Bisacodyl is a medicine that helps you have a bowel movement.
Compare with granisetron →
bismuth subsalicylate
Pepto-Bismol
Bismuth subsalicylate (Pepto-Bismol) is a medicine that can treat diarrhea and upset stomach.
Compare with granisetron →
cimetidine
Tagamet
Cimetidine (Tagamet) reduces stomach acid.
Compare with granisetron →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for granisetron: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 10,198.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 18.19%.
- metaxalone Δ 0.14 pts · 3,268 reports · Muscle Relaxant 18.33%death share
- fondaparinux Δ 0.19 pts · 7,980 reports · Factor Xa Inhibitor (Injectable) 17.99%death share
- fluconazole Δ 0.20 pts · 67,703 reports · Azole Antifungal 17.99%death share
- goserelin Δ 0.25 pts · 12,855 reports · GnRH Agonist 18.44%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for granisetron
The FDA label for granisetron (sold under brand names such as Kytril) classifies it as a prescription-only medication in the 5-HT3 Receptor Antagonist (Antiemetic) class. Granisetron is used to prevent nausea and vomiting. Official labeling lists 6 commonly reported side effects, including Headache, Constipation, Weakness or fatigue.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 10,198 voluntary reports. The database also lists 3 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $1.39.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 21, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages