Prescription medication · Glycopeptide Antibiotic
vancomycin
Also sold as Vancocin. Vancomycin treats serious infections caused by bacteria that are resistant to some other antibiotics.
Data updated 2026-05-15
- 55,549
- FDA reportsOften reported
- 6
- InteractionsFew interactions
- In shortage
- FDA status
What the data shows
vancomycin (Vancocin) is a prescription Glycopeptide Antibiotic, more reported than most tracked drugs (55,549 FDA reports), with 6 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
vancomycin (Vancocin) is a prescription Glycopeptide Antibiotic. Vancomycin treats serious infections caused by bacteria that are resistant to some other antibiotics.
Vancomycin is a strong antibiotic. It fights serious infections caused by certain bacteria.
Verify with FDA → · CMS NADAC pricing →
Drug Shortage Alert
vancomycin is currently listed as to be discontinued by the FDA. Affected manufacturer: Hospira, Inc., a Pfizer Company.
View all drug shortages →Drug Pricing (NADAC)
Generic Price
$2.75/unit
Generic Available
Yes (37 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
NADAC price trail: VANCOMYCIN 1 GM VIAL
Same CMS presentation as the headline generic unit price above (2 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: +8.6% vs prior release.
| Effective | NADAC / unit | vs prior | NDCs |
|---|---|---|---|
| November 20, 2024 | $2.54/EA | - | 1 |
| December 18, 2024 | $2.75/EA | +8.6% | 17 |
What it does
Vancomycin treats serious infections caused by bacteria that are resistant to some other antibiotics.
Common side effects
Flushing of the upper body ('red neck'), Pain or muscle spasm in the chest and back, Inflammation at the injection site
Key warnings
Rapid infusions of vancomycin can cause a sudden drop in blood pressure, wheezing, trouble breathing, hives, or itching.
The sections below are summarized in plain English from vancomycin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Vancomycin works by stopping bacteria from building their cell walls. Without a cell wall, the bacteria cannot survive. This helps your body fight off the infection.
Side Effects (from patient reports)
Based on 55,549 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for vancomycin, by number of reports
- Acute Kidney Injury
Acute Kidney Injury
4,178 reports
- Pyrexia
Pyrexia
3,514 reports
- Drug Reaction With Eosinophilia And Systemic Symptoms
Drug Reaction With Eosinophilia And Systemic Symptoms
2,311 reports
- Renal Failure
Renal Failure
2,198 reports
- Sepsis
Sepsis
2,062 reports
- Diarrhoea
Diarrhoea
2,034 reports
- Pneumonia
Pneumonia
1,906 reports
- Hypotension
Hypotension
1,882 reports
- Rash
Rash
1,821 reports
- Condition Aggravated
Condition Aggravated
1,807 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for vancomycin each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where vancomycin sits
vancomycin has more FDA adverse-event reports than 75% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is vancomycin; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 55,549 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 1999–2025.
Total Reports
55,549
Reports Mentioning Death
11,029
19.9% of reports — not proof of cause
Hospitalization Reports
30,109
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | ACUTE KIDNEY INJURY | 4,178 |
| 4 | PYREXIA | 3,514 |
| 5 | DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS | 2,311 |
| 6 | RENAL FAILURE | 2,198 |
| 7 | SEPSIS | 2,062 |
| 8 | DIARRHOEA | 2,034 |
| 9 | PNEUMONIA | 1,906 |
| 10 | HYPOTENSION | 1,882 |
| 11 | RASH | 1,821 |
| 12 | CONDITION AGGRAVATED | 1,807 |
| 13 | DYSPNOEA | 1,605 |
| 14 | SEPTIC SHOCK | 1,557 |
| 15 | NAUSEA | 1,534 |
| 16 | THROMBOCYTOPENIA | 1,526 |
| 17 | PAIN | 1,478 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Rapid infusions of vancomycin can cause a sudden drop in blood pressure, wheezing, trouble breathing, hives, or itching. Severe skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis have also been reported.
Known Drug Interactions
Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and nonsteroidal anti-inflammatory agents] is contraindicated.
Mechanism: Both drugs can harm the kidneys. Taking them at the same time increases the risk of serious kidney damage.
Monitor renal function in patients receiving vancomycin and concurrent and/or sequential systemic or topical use of other potentially, neurotoxic and/or nephrotoxic drugs, such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, or cisplatin.
Mechanism: Both of these drugs can be harmful to the kidneys, and using them at the same time increases the risk of kidney damage.
Monitor renal function in patients receiving vancomycin and concurrent and/or sequential systemic or topical use of other potentially, neurotoxic and/or nephrotoxic drugs, such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, or cisplatin.
Mechanism: Both of these medicines can be harmful to the kidneys when used at the same time.
( 7.2 ) • Co-administration of ZOSYN with vancomycin may increase the incidence of acute kidney injury. Monitor kidney function in patients receiving ZOSYN and vancomycin. 7.3 Vancomycin Studies have detected an increased incidence of acute kidney injury in patients concomitantly administered piperacillin and tazobactam and vancomycin as compared to vancomycin alone [see Warnings and Precautions (5.6) ] .
Mechanism: Taking these two antibiotics together can increase the risk of sudden damage to your kidneys.
[See Clinical Pharmacology (12.4).] 7.2 Cationic Drugs Although drug interactions for metformin with cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of AVANDAMET and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system.
Mechanism: These medications compete for the same disposal path in the kidneys, which could potentially affect how they are cleared from your body.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What if I am allergic to vancomycin?
Can vancomycin affect my kidneys?
Can vancomycin affect my hearing?
What should I tell my doctor before taking vancomycin?
Can vancomycin cause diarrhea?
What are the symptoms of an allergic reaction to vancomycin?
How will my doctor monitor me while I'm taking vancomycin?
Can I take vancomycin orally?
What should I do if I experience side effects while taking vancomycin?
Are there any long-term side effects of vancomycin?
What are the common side effects of vancomycin?
Does vancomycin interact with other medications?
What drug class is vancomycin?
What pregnancy or breastfeeding source fields are listed for vancomycin?
Has vancomycin been recalled?
Is vancomycin currently in shortage?
Active Recalls
Lack of Assurance of Sterility; blue Break-Off-Part could detach from the administration port
Fagron Compounding Services
Lack of Assurance of Sterility; blue Break-Off-Part could detach from the administration port
Fagron Compounding Services
Lack of Assurance of Sterility; blue Break-Off-Part could detach from the administration port
Fagron Compounding Services
Lack of Assurance of Sterility
Fresenius Kabi Compounding, LLC
Lack of Assurance of Sterility
Fresenius Kabi Compounding, LLC
Superpotent Drug: semi-automated IV bag filling system can malfunction and provide a double dose of drug product to IV bags.
Denver Solutions, LLC DBA Leiters Health
Superpotent Drug: semi-automated IV bag filling system can malfunction and provide a double dose of drug product to IV bags.
Denver Solutions, LLC DBA Leiters Health
Lack of Assurance of Sterility
Apollo Care, LLC
Lack of Assurance of Sterility
Apollo Care, LLC
Lack of Assurance of Sterility
Apollo Care, LLC
Lack of Assurance of Sterility
Apollo Care, LLC
Lack of Assurance of Sterility
Apollo Care, LLC
Lack of Assurance of Sterility; All lots of sterile products compounded by the pharmacy within expiry are subject to this recall. This recall is initiated due to concerns associated with quality control procedures observed during a recent FDA inspection.
Franck's Lab Inc dba Trinity Care Solutions
Lack of Assurance of Sterility; All lots of sterile products compounded by the pharmacy within expiry are subject to this recall. This recall is initiated due to concerns associated with quality control procedures observed during a recent FDA inspection.
Franck's Lab Inc dba Trinity Care Solutions
Lack of Assurance of Sterility; All lots of sterile products compounded by the pharmacy within expiry are subject to this recall. This recall is initiated due to concerns associated with quality control procedures observed during a recent FDA inspection.
Franck's Lab Inc dba Trinity Care Solutions
Related Medications in Glycopeptide Antibiotic
Other drugs grouped near vancomycin - same-class peers and common alternatives.
amikacin
Amikin
Amikacin is an antibiotic medicine.
Compare with vancomycin →
amoxicillin
Amoxil
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.
Compare with vancomycin →
amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
Compare with vancomycin →
ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
Compare with vancomycin →
azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
Compare with vancomycin →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for vancomycin: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 55,549.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 19.85%.
- metolazone Δ 0.06 pts · 10,872 reports · Thiazide-Like Diuretic 19.91%death share
- itraconazole Δ 0.17 pts · 11,311 reports · Azole Antifungal 19.69%death share
- temazepam Δ 0.20 pts · 36,917 reports · Benzodiazepine (Hypnotic) 20.06%death share
- enzalutamide Δ 0.24 pts · 57,614 reports · Androgen Receptor Inhibitor 19.61%death share
Medication Guides
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Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for vancomycin
The FDA label for vancomycin (sold under brand names such as Vancocin) classifies it as a prescription-only medication in the Glycopeptide Antibiotic class. Vancomycin treats serious infections caused by bacteria that are resistant to some other antibiotics. Official labeling lists 3 commonly reported side effects, including Flushing of the upper body ('red neck'), Pain or muscle spasm in the chest and back, Inflammation at the injection site.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 55,549 voluntary reports. The database also lists 6 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $2.75.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 15 recall records on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: January 30, 2026
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages