glycopyrrolate
Brand names: Seebri, Lonhala
Glycopyrrolate injection reduces body secretions before and during surgery. It can also help manage peptic ulcers in adults when quick action is needed.
Drug Pricing (NADAC)
Generic Price
$1.40/unit
Generic Available
Yes (38 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine can help reduce saliva and other secretions before surgery.
Common side effects
Dry mouth, Trouble urinating, Blurred vision
Key warnings
This medicine contains benzyl alcohol, which can be harmful to newborns.
How It Works
Glycopyrrolate blocks the action of a chemical called acetylcholine. This chemical can cause increased saliva, stomach acid, and other body fluids. By blocking acetylcholine, glycopyrrolate reduces these secretions.
How to Take It
A healthcare provider will give you this medicine as an injection into a muscle or vein. The dose depends on why you are getting the medicine. For peptic ulcers, the usual dose is 0.1 mg every 4 hours, 3 to 4 times a day.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant or breastfeeding. It is not known if glycopyrrolate will harm an unborn baby. This medicine may also reduce breast milk production.
Missed Dose
Since a healthcare provider is giving you this medicine, you are unlikely to miss a dose. Call your doctor if you have concerns.
Storage
Store at room temperature, away from heat and light.
Side Effects (from patient reports)
Based on 5,420 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 5,225 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2001–2025.
Total Reports
5,225
Death-Related Reports
630
Hospitalization Reports
2,218
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DYSPNOEA | 1,000 |
| 2 | ASTHMA | 793 |
| 3 | WHEEZING | 674 |
| 4 | COUGH | 626 |
| 5 | PNEUMONIA | 538 |
| 6 | DRUG INEFFECTIVE | 411 |
| 7 | FATIGUE | 352 |
| 8 | OFF LABEL USE | 351 |
| 9 | MALAISE | 345 |
| 10 | PRODUCTIVE COUGH | 330 |
| 11 | CHEST DISCOMFORT | 327 |
| 12 | CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 326 |
| 13 | CONDITION AGGRAVATED | 311 |
| 14 | NAUSEA | 311 |
| 15 | PYREXIA | 304 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
This medicine contains benzyl alcohol, which can be harmful to newborns. If you have glaucoma, trouble urinating, or a blockage in your stomach or intestines, you should not take this medicine for peptic ulcer treatment.
Known Drug Interactions
Concomitant administration of glycopyrrolate injection and potassium chloride in a wax matrix may increase the severity of potassium chloride-induced gastrointestinal lesions as a result of a slower gastrointestinal transit time.
Mechanism: Glycopyrrolate slows down your digestion, which can cause potassium tablets to sit in your stomach or intestines too long and cause sores.
What to do: Talk to your doctor about this combination and report any new stomach pain or digestive issues immediately.
No significant adverse interactions with commonly used premedications or drugs used during anesthesia and surgery (including atropine, scopolamine, glycopyrrolate, diazepam, hydroxyzine, d-tubocurarine, succinylcholine and other nondepolarizing muscle relaxants) or topical local anesthetics (including lidocaine, dyclonine HCl and Cetacaine) have been observed in adults or pediatric patients.
Mechanism: These drugs do not have any known harmful interactions when used together during surgery or anesthesia.
What to do: This combination is considered safe to use, and no special changes are needed.
Common Questions
What should I tell my doctor before taking glycopyrrolate?
Can I take glycopyrrolate with other medicines?
What are the signs of an allergic reaction?
Can glycopyrrolate cause mental confusion?
What should I do if I experience severe side effects?
Is glycopyrrolate safe for children?
How is glycopyrrolate given?
Can glycopyrrolate affect my vision?
Can glycopyrrolate cause constipation?
Who makes this medicine?
What are the common side effects of glycopyrrolate?
Does glycopyrrolate interact with other medications?
What drug class is glycopyrrolate?
Is glycopyrrolate safe during pregnancy?
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What the FDA Data Shows for glycopyrrolate
The FDA label for glycopyrrolate (sold under brand names such as Seebri, Lonhala) classifies it as a prescription-only medication in the Long-Acting Muscarinic Antagonist (LAMA) class. This medicine can help reduce saliva and other secretions before surgery. Official labeling lists 15 commonly reported side effects, including Dry mouth, Trouble urinating, Blurred vision.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 5,420 voluntary reports. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $1.40.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: November 18, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages