Prescription medicine
Trimethobenzamide Brand names: Tigan
Trimethobenzamide (Tigan) is a prescription medicine with an FDA approval on record since 1974. FDA's NDC Directory lists it from 5 generic labelers.
- Generic listed
Check it at the source: the trimethobenzamide FDA label on DailyMed (effective March 10, 2026, Par Health USA, LLC); the NDA 17531 record on Drugs@FDA; every trimethobenzamide label on DailyMed.
Highlights of the record
FDA label of March 10, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageTigan ® is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
Forms and strengths
- 300 mg
- 100 mg/ml
Capsule; injection.
On the market
- Earliest approval on file
- July 12, 1974 Tigan, King Pharms Llc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 9 first October 19, 1982; 3 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 8 of which 5 under generic applications, 3 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 0 since 2013 0 Class I among all firms' recalls; 1 more by firms not listed as its makers
- FAERS reports
- 1,415 through July 30, 2026
What is trimethobenzamide used for?
From the label: indications and usageTigan ® is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
Conditions named in the indications of trimethobenzamide's FDA labels, with every medicine labeled for each:
From other trimethobenzamide labelsNausea and vomiting: INDICATIONS Tigan ® is indicated for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
FDA pharmacologic class: Antiemetic.
Source: FDA drug label (Tigan), Par Health USA, LLC, effective March 10, 2026 (SPL set 7da90678-b229-4ad6-9193-2b8a3e9ba695), via openFDA; the full label on DailyMed
Is there a generic for trimethobenzamide (Tigan)?
The FDA approved the first generic trimethobenzamide on October 19, 1982. 9 generic applications are approved; 3 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists trimethobenzamide from 5 labelers under a generic (ANDA) application and from 3 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1974 earliest approval on file
- 1982 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
Has trimethobenzamide been recalled?
The FDA's Enforcement Report lists 1 recall naming trimethobenzamide since 2013: 0 Class I (the most serious), 1 Class II, 0 Class III; 0 still ongoing. 1 of them is by a firm that FDA's NDC Directory does not list as a maker of trimethobenzamide and that holds no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| July 2, 2013 | Class II | Aidapak Services, LLC not a listed maker | Labeling: Label Mixup; TRIMETHOBENZAMIDE HCl, Capsule, 300 mg may be potentially mislabeled as GABAPENTIN, Tablet, 600 mg, NDC 00228263611, Pedigree … |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the trimethobenzamide label say about other medicines?
The trimethobenzamide label names no other medicine on this site. The labels of 1 other medicine name trimethobenzamide. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
Other labels that name trimethobenzamide
Source: FDA drug label (Tigan), Par Health USA, LLC, effective March 10, 2026 (SPL set 7da90678-b229-4ad6-9193-2b8a3e9ba695), via openFDA; the full label on DailyMed
What do FAERS reports show for trimethobenzamide?
The FDA Adverse Event Reporting System holds 1,415 reports that list trimethobenzamide among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 61 are coded as a death and 273 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as trimethobenzamide?
7 other medicines are given the same way (oral) and in the same FDA class as trimethobenzamide or labeled mainly for the same use (nausea and vomiting), the same class first. Nausea and vomiting lists all 16 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Meclizine | Nausea and vomiting | 24 labelers | $0.0442 per tablet 12.5 mg tablet | No current entry |
| Ondansetron | Nausea and vomiting | 60 labelers | $0.0582 per tablet 4 mg tablet | No current entry |
| Prochlorperazine | Nausea and vomiting | 29 labelers | $0.162 per tablet 10 mg tablet | No current entry |
| Dimenhydrinate | Nausea and vomiting | none listed | $0.0575 per tablet 50 mg tablet | No current entry |
| Aprepitant | Nausea and vomiting | 5 labelers | $46.42 per capsule 40 mg capsule | A presentation being discontinued |
| Doxylamine and pyridoxine | Nausea and vomiting | 4 labelers | $1.09 per unit 10-10 mg | No current entry |
| Tradipitant | Nausea and vomiting | none listed | n/a | No current entry |
Every medicine labeled for the same conditions as trimethobenzamide
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to trimethobenzamide
- 7 medicines for the same use
- Other antiemetics
- the pharmacologic class, with prices and generics
- Trimethobenzamide side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other