Prescription medication · NS5B/NS5A Inhibitor (HCV)

sofosbuvir/velpatasvir

Name: sofosbuvir/velpatasvir - FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Also sold as Epclusa. Vosevi treats chronic hepatitis C (HCV) infection in adults.

Compiled by PlainMeds Editorial, Drug Information Editorial Team

Data updated 2026-05-15

12,618
FDA reports: 33
InteractionsSeveral interactions: $862.51
Brand price (NADAC)

What the data shows

sofosbuvir/velpatasvir (Epclusa) is a prescription NS5B/NS5A Inhibitor (HCV), with 12,618 FDA adverse-event reports on file, with 33 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

sofosbuvir/velpatasvir (Epclusa) is a prescription NS5B/NS5A Inhibitor (HCV). Vosevi treats chronic hepatitis C (HCV) infection in adults.

Vosevi is a drug that combines three medicines into one tablet. It is used to treat hepatitis C in adults who have already tried other treatments.

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Drug Pricing (NADAC)

Brand Price

$862.51/unit

Generic Available

GILEAD SCIENCES INC

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

Vosevi treats chronic hepatitis C (HCV) infection in adults.

Common side effects

Headache, Fatigue (feeling tired), Diarrhea

Key warnings

Vosevi can cause Hepatitis B to become active again if you have had it in the past.

The sections below are summarized in plain English from sofosbuvir/velpatasvir's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Vosevi contains sofosbuvir, velpatasvir, and voxilaprevir. Sofosbuvir blocks a protein called NS5B polymerase that the hepatitis C virus needs to multiply. Velpatasvir blocks the NS5A protein, and voxilaprevir blocks the NS3/4A protease protein, both of which the virus also needs.

How to Take It

Take one Vosevi tablet once a day with food. The tablet contains 400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir. You will likely take Vosevi for 12 weeks. Follow your doctor's instructions carefully.

This is a plain-language summary of sofosbuvir/velpatasvir's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.

Pregnancy & Breastfeeding

It is not known if Vosevi can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Vosevi passes into breast milk, so discuss this with your doctor if you are breastfeeding.

This is a plain-language summary of sofosbuvir/velpatasvir's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.

Missed Dose

If you miss a dose of Vosevi, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.

This is a plain-language summary of sofosbuvir/velpatasvir's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.

Storage

Store Vosevi tablets below 86°F (30°C) in the original container.

Side Effects (from patient reports)

Based on 12,618 FDA adverse event reports.

Feeling tired

2,307
Hepatitis C infection

1,734
Headache

1,639
Feeling sick to your stomach

1,386
Low red blood cell count

1,185
Trouble sleeping

1,059
Liver cancer

911
The treatment did not work

836
Difficulty breathing

783
Weakness

778

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Serious Warnings

Vosevi can cause Hepatitis B to become active again if you have had it in the past. This can cause serious liver problems, including liver failure and death. Before starting Vosevi, your doctor will test you for Hepatitis B. They will also monitor you during and after treatment.

Known Drug Interactions

major rifampin

Antimycobacterials: rifampin ↓ sofosbuvir ↓ velpatasvir ↑ voxilaprevir (single dose) ↓ voxilaprevir (multiple dose) Coadministration with rifampin is contraindicated [see Contraindications (4) ].

Mechanism: Rifampin causes your body to process the hepatitis C medicine too quickly, which lowers the amount of medicine in your blood.

What to do: You should not take these two drugs together because the hepatitis C treatment will likely fail.

major rosuvastatin

Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dose of rosuvastatin 10 mg once daily.

Mechanism: This hepatitis C medication can increase the amount of rosuvastatin that stays in your blood.

What to do: If you take these together, start with a low 5 mg dose of rosuvastatin and do not take more than 10 mg per day.

major rosuvastatin/ezetimibe

Mechanism: This antiviral medicine increases the amount of rosuvastatin in your system by changing how your body processes it. Higher levels of the drug can increase the risk of muscle damage.

What to do: You should start with a low 5 mg dose of rosuvastatin and never take more than 10 mg daily while using this combination.

moderate pravastatin

HMG-CoA Reductase Inhibitors: pravastatin ↑ pravastatin Coadministration of VOSEVI with pravastatin has been shown to increase the concentration of pravastatin, which is associated with increased risk of myopathy, including rhabdomyolysis. Pravastatin may be administered with VOSEVI at a dose that does not exceed pravastatin 40 mg.

Mechanism: This medication increases the amount of pravastatin that stays in your blood, which makes muscle injury more likely.

What to do: If you take these medicines together, do not take more than 40 mg of pravastatin each day.

moderate methotrexate

Coadministration of VOSEVI with BCRP substrates (e.g., methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan) is not recommended [see Clinical Pharmacology (12.3) ].

Mechanism: This medication can block a specific protein that helps move methotrexate out of your body, which may lead to higher levels of methotrexate in your system.

What to do: Taking these two drugs together is not recommended. Your doctor may need to choose a different medication for you.

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This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.

Common Questions

Can I take Vosevi if I have kidney problems?

Yes, you can take Vosevi if you have kidney problems, including if you are on dialysis. No dose change is needed.

Can I take Vosevi if I have liver problems?

Vosevi is not recommended if you have moderate or severe liver problems (Child-Pugh B or C).

What should I tell my doctor before starting Vosevi?

Tell your doctor about all your medical conditions, including any liver or kidney problems, and if you have ever had hepatitis B. Also, tell them about all the medicines you take, including prescriptions, over-the-counter medicines, vitamins, and herbal supplements.

Can Vosevi interact with other medications?

Yes, Vosevi can interact with other medications. Some medicines can make Vosevi less effective. Talk to your doctor or pharmacist before starting Vosevi.

What if I experience side effects while taking Vosevi?

Tell your doctor if you experience any side effects while taking Vosevi. They can help you manage the side effects.

Can I drink alcohol while taking Vosevi?

Talk to your doctor about whether it is safe for you to drink alcohol while taking Vosevi.

How will I know if Vosevi is working?

Your doctor will do blood tests to check the level of hepatitis C virus in your blood. This will help them see if the medicine is working.

Is there a cure for hepatitis C?

Vosevi can cure hepatitis C in many people. However, it is important to follow your doctor's instructions and finish the full course of treatment.

What happens if I stop taking Vosevi early?

Do not stop taking Vosevi without talking to your doctor first. Stopping the medicine early may make the treatment less effective.

Are there any foods I should avoid while taking Vosevi?

Vosevi should be taken with food. There are no specific foods you need to avoid while taking Vosevi.

What are the common side effects of sofosbuvir/velpatasvir?

The most commonly reported side effects of sofosbuvir/velpatasvir include Headache, Fatigue (feeling tired), Diarrhea, Nausea (feeling sick to your stomach). Based on 12,618 FDA adverse event reports. Always consult your healthcare provider about potential side effects.

Does sofosbuvir/velpatasvir interact with other medications?

Yes, sofosbuvir/velpatasvir has 33 known drug interactions. Notable interactions include rifampin, rosuvastatin, rosuvastatin/ezetimibe. Always inform your doctor about all medications you are taking.

What drug class is sofosbuvir/velpatasvir?

sofosbuvir/velpatasvir belongs to the NS5B/NS5A Inhibitor (HCV) drug class. It requires a prescription (Rx). Vosevi treats chronic hepatitis C (HCV) infection in adults.

Is sofosbuvir/velpatasvir safe during pregnancy?

It is not known if Vosevi can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Always consult your healthcare provider before using any medication during pregnancy or breastfeeding.

Related Medications in NS5B/NS5A Inhibitor (HCV)

Other drugs grouped near sofosbuvir/velpatasvir - same-class peers and common alternatives.

acyclovir

Zovirax

Acyclovir is an antiviral medicine.