Prescription medication · Azole Antifungal
voriconazole
Also sold as Vfend. This medicine treats several types of fungal infections.
Data updated 2026-05-15
- 29,380
- FDA reportsModerately reported
- 50
- InteractionsMany interactions
- In shortage
- FDA status
What the data shows
voriconazole (Vfend) is a prescription Azole Antifungal, reported at a middle-of-the-pack volume (29,380 FDA reports), with 50 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
voriconazole (Vfend) is a prescription Azole Antifungal. This medicine treats several types of fungal infections.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Verify with FDA → · CMS NADAC pricing →
Drug Shortage Alert
voriconazole is currently listed as to be discontinued by the FDA. Affected manufacturer: Pfizer Inc..
View all drug shortages →Drug Pricing (NADAC)
Generic Price
$1.56/unit
Generic Available
Yes (20 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine treats several types of fungal infections.
Common side effects
Visual disturbances, Fever, Nausea
Key warnings
Voriconazole can cause serious liver problems.
The sections below are summarized in plain English from voriconazole's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
Side Effects (from patient reports)
Based on 29,380 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for voriconazole, by number of reports
- Drug Interaction
Drug Interaction
2,315 reports
- Death
Death
1,460 reports
- Pyrexia
Pyrexia
1,411 reports
- Pneumonia
Pneumonia
1,321 reports
- Condition Aggravated
Condition Aggravated
1,093 reports
- Bronchopulmonary Aspergillosis
Bronchopulmonary Aspergillosis
1,028 reports
- Febrile Neutropenia 888
Febrile Neutropenia
888 reports
- Aspergillus Infection 873
Aspergillus Infection
873 reports
- Respiratory Failure 836
Respiratory Failure
836 reports
- Diarrhoea 759
Diarrhoea
759 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for voriconazole each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where voriconazole sits
voriconazole has more FDA adverse-event reports than 63% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is voriconazole; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 29,380 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
29,380
Reports Mentioning Death
8,672
29.5% of reports — not proof of cause
Hospitalization Reports
11,781
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 3 | DRUG INTERACTION | 2,315 |
| 4 | DEATH | 1,460 |
| 5 | PYREXIA | 1,411 |
| 6 | PNEUMONIA | 1,321 |
| 7 | CONDITION AGGRAVATED | 1,093 |
| 8 | BRONCHOPULMONARY ASPERGILLOSIS | 1,028 |
| 9 | FEBRILE NEUTROPENIA | 888 |
| 10 | ASPERGILLUS INFECTION | 873 |
| 11 | RESPIRATORY FAILURE | 836 |
| 12 | DIARRHOEA | 759 |
| 13 | NAUSEA | 752 |
| 14 | DYSPNOEA | 725 |
| 16 | NEUTROPENIA | 706 |
| 17 | SEPSIS | 693 |
| 18 | SEPTIC SHOCK | 674 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Known Drug Interactions
John's Wort (CYP450 inducer; P-gp inducer) Significantly Reduced Contraindicated Oral Contraceptives containing ethinyl estradiol and norethindrone (CYP2C19 Inhibition) Increased Monitoring for adverse reactions and toxicity related to voriconazole is recommended when coadministered with oral contraceptives. Oral Contraceptives containing ethinyl estradiol and norethindrone (CYP3A4 Inhibition) Increased Monitoring for adverse reactions related to oral contraceptives is recommended during coadministration.
Mechanism: Voriconazole slows down the process your body uses to get rid of the birth control pill. This can lead to higher levels of the birth control in your blood and increase your risk of side effects.
Table 10: Effect of Other Drugs on Voriconazole Pharmacokinetics [see Clinical Pharmacology (12.3)] Drug/Drug Class (Mechanism of Interaction by the Drug) Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours) Recommendations for Voriconazole Dosage Adjustment/Comments Rifampin Results based on in vivo clinical studies generally following repeat oral dosing with 200 mg every 12 hours voriconazole to healthy subjects and Rifabutin (CYP450 Induction) Significantly Reduced Contraindicated Efavirenz (400 mg every 24 hours) Results based on in vivo clinical study following...
Mechanism: Rifampin causes your body to break down voriconazole much faster than normal. This makes the voriconazole level in your blood too low to effectively treat your infection.
Ergot Alkaloids (CYP450 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated Naloxegol (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased which may Increase the Risk of Adverse Reactions Contraindicated Tolvaptan (CYP3A4 Inhibition) Although Not Studied Clinically, Voriconazole is Likely to Significantly Increase the Plasma Concentrations of Tolvaptan Contraindicated Lurasidone (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Voriconazole is Likely to Significantly Increase...
Mechanism: Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
Pimozide, Quinidine, Ivabradine (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated because of potential for QT prolongation and rare occurrence of torsade de pointes.
Mechanism: Voriconazole prevents your body from breaking down pimozide, which can lead to very high levels of the drug in your blood. This can cause dangerous and potentially fatal heart rhythm problems.
Pimozide, Quinidine, Ivabradine (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated because of potential for QT prolongation and rare occurrence of torsade de pointes.
Mechanism: Voriconazole stops the body from breaking down ivabradine, which can lead to dangerously high levels of the drug in the blood. This increase can cause serious and potentially life-threatening heart rhythm problems.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take voriconazole if I am allergic to other antifungal medicines?
Can I take voriconazole with other medicines?
How often will I need blood tests while taking voriconazole?
What should I do if I experience visual disturbances while taking voriconazole?
Can voriconazole affect my heart?
What should I do to protect myself from sunlight while taking voriconazole?
Is it safe to take voriconazole during pregnancy?
Can I breastfeed while taking voriconazole?
What are the symptoms of liver problems I should watch out for?
What should I do if I think I am having an allergic reaction to voriconazole?
What are the common side effects of voriconazole?
Does voriconazole interact with other medications?
What drug class is voriconazole?
What pregnancy or breastfeeding source fields are listed for voriconazole?
Has voriconazole been recalled?
Is voriconazole currently in shortage?
Active Recalls
CGMP Deviations
Glenmark Pharmaceuticals Inc., USA
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Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for voriconazole: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 29,380.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 29.52%.
- rifaximin Δ 0.08 pts · 19,891 reports · Non-Systemic Antibiotic (IBS-D) 29.44%death share
- meropenem Δ 0.45 pts · 30,400 reports · Carbapenem Antibiotic 29.97%death share
- buprenorphine Δ 0.85 pts · 90,121 reports · Partial Opioid Agonist 28.67%death share
- oxycodone Δ 0.98 pts · 180,422 reports · Opioid Analgesic 28.54%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for voriconazole
The FDA label for voriconazole (sold under brand names such as Vfend) classifies it as a prescription-only medication in the Azole Antifungal class. This medicine treats several types of fungal infections. Official labeling lists 7 commonly reported side effects, including Visual disturbances, Fever, Nausea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 29,380 voluntary reports. The database also lists 50 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $1.56.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: March 28, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages