Prescription medicine
Phenytoin Brand names: Dilantin, Phenytek; first approved as Dilantin-125
Phenytoin (Dilantin) is a prescription medicine with an FDA approval on record since 1953. FDA's NDC Directory lists it from 29 generic labelers, and pharmacies paid $0.145 per phenytoin sod ext 100 mg capsule in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.); the NDA 8762 record on Drugs@FDA; every phenytoin label on DailyMed.
Highlights of the record
FDA label of October 15, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usagePHENYTEK ® capsules (extended phenytoin sodium capsules) are indicated for the treatment of tonic-clonic (grand mal) and psychomotor (temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery.
Forms and strengths
- 30 mg
- 50 mg
- 100 mg
- 200 mg
- 300 mg
- 50 mg/ml
- 125 mg/5ml
Extended-release capsule; injection; chewable tablet; capsule; suspension.
On the market
- Earliest approval on file
- January 6, 1953 Dilantin-125, Viatris; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 35 first July 16, 1975; 12 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 29 of which 29 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.145 per capsule Phenytoin sod ext 100 mg capsule
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 11 since 2013 2 Class I among all firms' recalls; latest October 27, 2023
- FAERS reports
- 40,278 through July 30, 2026
What is phenytoin used for?
From the label: indications and usagePHENYTEK ® capsules (extended phenytoin sodium capsules) are indicated for the treatment of tonic-clonic (grand mal) and psychomotor (temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery. PHENYTEK ® CAPSULES are indicated for the treatment of tonic-clonic (grand mal) and psychomotor (temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery.
Conditions named in the indications of phenytoin's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Anti-epileptic Agent.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
What does the patient leaflet for phenytoin say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about PHENYTEK ® CAPSULES?Do not stop taking PHENYTEK ® CAPSULES without first talking to your healthcare provider. • Stopping PHENYTEK ® CAPSULES suddenly can cause serious problems. • Stopping a seizure medicine suddenly can cause you to have seizures more often or seizures that will not stop (status epilepticus). 2. Like other antiepileptic drugs, PHENYTEK ® CAPSULES may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you: • Thoughts about suicide or dying • Attempts to commit suicide • New or worse depression • New or worse anxiety • Feeling agitated or restless • Panic attacks • Trouble sleeping (insomnia) • New or worse irritability • Acting aggressive, being angry, or violent • Acting on dangerous impulses • An extreme increase in activity and talking (mania) • Other unusual changes in behavior or mood Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes. How can I watch for early symptoms of suicidal thoughts and actions? • Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. • Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you are worried about symptoms. 3. PHENYTEK ® CAPSULES can cause a type of serious allergic reaction that may affect different parts of the body such as your liver, kidneys, blood, heart, skin or other parts of your body. These can be very serious and cause death. […]
From the patient leaflet: What should I avoid while taking PHENYTEK ® CAPSULES?Do not drink alcohol while you take PHENYTEK ® CAPSULES without first talking to your healthcare provider. Drinking alcohol while taking PHENYTEK ® CAPSULES may change your blood levels of phenytoin sodium which can cause serious problems. • Do not drive, operate heavy machinery, or do other dangerous activities until you know how PHENYTEK ® CAPSULES affect you. PHENYTEK ® CAPSULES can slow your thinking and motor skills.
From the patient leaflet: How should I store PHENYTEK ® CAPSULES?Store PHENYTEK ® CAPSULES at room temperature between 20° to 25°C (68° to 77°F). • Store in tight, light-resistant containers. • Protect from light and moisture. Keep PHENYTEK ® CAPSULES and all medicines out of the reach of children.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
Is there a generic for phenytoin (Dilantin)?
The FDA approved the first generic phenytoin on July 16, 1975. 35 generic applications are approved; 12 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists phenytoin from 29 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1953 earliest approval on file
- 1975 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for phenytoin (Dilantin)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.145 per Phenytoin sod ext 100 mg capsule, down 5% from $0.152 on October 8, 2025. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Phenytoin sod ext 100 mg capsule (generic)
- Dilantin 100 mg capsule (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Phenytoin 125 mg/5 mL suspension | Generic | $0.0748 per mL | n/a | +8% |
| Phenytoin 50 mg infatab chewable | Generic | $0.201 per unit | n/a | -6% |
| Phenytoin 50 mg tablet chewable | Generic | $0.201 per tablet | $6.04 | -6% |
| Phenytoin sod ext 100 mg capsule | Generic | $0.145 per capsule | $4.35 | -5% |
| Dilantin 100 mg capsule | Brand | $1.74 per capsule | $52.16 | +5% |
| Dilantin 30 mg capsule | Brand | $1.50 per capsule | $44.97 | +5% |
| Dilantin 50 mg infatab | Brand | $1.58 per unit | n/a | +4% |
| Phenytek 200 mg capsule | Brand | $1.40 per capsule | $42.08 | -0.2% |
| Phenytek 300 mg capsule | Brand | $2.10 per capsule | $62.93 | +0.3% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has phenytoin been recalled?
The FDA's Enforcement Report lists 11 recalls naming phenytoin since 2013: 2 Class I (the most serious), 7 Class II, 2 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| October 27, 2023 | Class II | Amneal Pharmaceuticals of New York, LLC | Failed Dissolution Specifications |
| October 23, 2023 | Class I | The Harvard Drug Group LLC dba Major Pharmaceuticals and … | Failed Content Uniformity Specifications |
| May 30, 2023 | Class II | Amneal Pharmaceuticals of New York, LLC | Failed Dissolution Specifications: Out-of-specification results for dissolution (above specification) |
| November 14, 2022 | Class III | Acella Pharmaceuticals, LLC | Labeling: Not elsewhere classified; the product is being recalled because of customer complaints that the primary vial label was missing a barcode. |
| February 7, 2020 | Class I | Taro Pharmaceuticals U.S.A., Inc. | Resuspension Problems: Two lots of Phenytoin Oral Suspension USP 125mg/5mL may coagulate and may not resuspend as per the label copy instructions. |
| January 18, 2017 | Class II | VistaPharm, Inc. | CGMP Deviations: Purified water used to manufacture the drug products may have been contaminated with Burkholderia cepacia. |
| April 22, 2015 | Class II | Wockhardt Usa Inc. | CGMP Deviations: Firm did not adequately investigate customer complaints. |
| October 15, 2013 | Class II | VistaPharm, Inc. | Defective Container: A lidding deformity allowed for the product to have out of specification results for assay and viscosity at the12 month stability … |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the phenytoin label say about other medicines?
The phenytoin label names 81 other medicines in its interaction, contraindication or warning sections. The labels of 46 other medicines name phenytoin. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Albendazole | drug interactions | Interacting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine |
| Amiodarone | drug interactions | Interacting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin |
| Apixaban | drug interactions | Interacting Agent: Anticoagulants; Examples: Apixaban, dabigatran, edoxaban, rivaroxaban |
| Atorvastatin | drug interactions | Interacting Agent: Antilipidemic agents; Examples: Atorvastatin, fluvastatin, simvastatin |
| Bleomycin | drug interactions | Interacting Agent: Antineoplastic agents usually in combination; Examples: Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate |
| Calcium carbonate | drug interactions | Interacting Agent: Antacids Antacids may affect absorption of phenytoin.; Examples: Calcium carbonate, aluminum hydroxide, magnesium hydroxide Prevention or Management: Phenytoin and antacids should not be taken at the same time of day |
| Capecitabine | drug interactions | Interacting Agent: Antineoplastic agents; Examples: Capecitabine, fluorouracil |
| Carbamazepine | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Carbamazepine, vigabatrin |
| Carboplatin | drug interactions | Interacting Agent: Antineoplastic agents usually in combination; Examples: Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate |
| Chloramphenicol | drug interactions | Interacting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin |
| Chlordiazepoxide | drug interactions | Interacting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin |
| Cimetidine | drug interactions | Interacting Agent: Gastric acid reducing agents; Examples: H 2 antagonists (cimetidine), omeprazole |
| Cisatracurium | drug interactions | Interacting Agent: Neuromuscular blocking agents; Examples: Cisatracurium, pancuronium, rocuronium and vecuronium: resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular blocking agents has occurred in patients chronically administered phenytoin. … |
| Cisplatin | drug interactions | Interacting Agent: Antineoplastic agents usually in combination; Examples: Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate |
Every other medicine the phenytoin label names
| Medicine named | Section | What the label says |
|---|---|---|
| Clozapine | drug interactions | Interacting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel … |
| Cyclosporine | drug interactions | Interacting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel … |
| Dabigatran | drug interactions | Interacting Agent: Anticoagulants; Examples: Apixaban, dabigatran, edoxaban, rivaroxaban |
| Diazepam | drug interactions | Interacting Agent: Other; Examples: Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. John’s wort The induction potency of St. … |
| Diazoxide | drug interactions | Interacting Agent: Other; Examples: Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. John’s wort The induction potency of St. … |
| Digoxin | drug interactions | Interacting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel … |
| Disopyramide | drug interactions | Interacting Agent: Other; Examples: Albendazole (decreases active metabolite), chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel … |
| Disulfiram | drug interactions | Interacting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates … |
| Divalproex | drug interactions | Calcium carbonate, aluminum hydroxide, magnesium hydroxide Prevention or Management: Phenytoin and antacids should not be taken at the same time of day Antineoplastic agents usually in combination … |
| Doxorubicin | drug interactions | Interacting Agent: Antineoplastic agents usually in combination; Examples: Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate |
| Doxycycline | drug interactions | Interacting Agent: Other; Examples: Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D |
| Edoxaban | drug interactions | Interacting Agent: Anticoagulants; Examples: Apixaban, dabigatran, edoxaban, rivaroxaban |
| Efavirenz | drug interactions | Interacting Agent: Antiviral agents; Examples: Efavirenz, lopinavir/ritonavir, indinavir, nelfinavir, ritonavir, saquinavir Fosamprenavir: phenytoin when given with fosamprenavir alone may decrease … |
| Ethosuximide | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate |
| Felbamate | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate |
| Fluconazole | drug interactions | Interacting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole |
| Fluorouracil | drug interactions | Interacting Agent: Antineoplastic agents; Examples: Capecitabine, fluorouracil |
| Fluoxetine | drug interactions | Interacting Agent: Antidepressants; Examples: Fluoxetine, fluvoxamine, sertraline |
| Fluvastatin | drug interactions | Interacting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates … |
| Fluvoxamine | drug interactions | Interacting Agent: Antidepressants; Examples: Fluoxetine, fluvoxamine, sertraline |
| Fosamprenavir | drug interactions | Interacting Agent: Antiviral agents; Examples: Fosamprenavir, nelfinavir, ritonavir |
| Furosemide | drug interactions | Interacting Agent: Other; Examples: Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D |
| Irinotecan | drug interactions | Interacting Agent: Antineoplastic agents; Examples: Irinotecan, paclitaxel, teniposide |
| Isoniazid | drug interactions | Interacting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates … |
| Itraconazole | drug interactions | Interacting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole |
| Ketoconazole | drug interactions | Interacting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole |
| Lacosamide | drug interactions | … Carbamazepine, felbamate, lamotrigine, topiramate, oxcarbazepine, lacosamide |
| Lamotrigine | drug interactions | … serum levels is unpredictable; Examples: Carbamazepine, felbamate, lamotrigine, topiramate, oxcarbazepine, lacosamide |
| Lopinavir and ritonavir | drug interactions | Warfarin Increased and decreased PT/INR responses have been reported when phenytoin is coadministered with warfarin Other Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives … |
| Magnesium hydroxide | drug interactions | Interacting Agent: Antacids Antacids may affect absorption of phenytoin.; Examples: Calcium carbonate, aluminum hydroxide, magnesium hydroxide Prevention or Management: Phenytoin and antacids should … |
| Methadone | drug interactions | … chlorpropamide, clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine |
| Methotrexate | drug interactions | Interacting Agent: Antineoplastic agents usually in combination; Examples: Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate |
| Methsuximide | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate |
| Methylphenidate | drug interactions | … chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin |
| Mexiletine | drug interactions | … clozapine, cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine |
| Miconazole | drug interactions | Interacting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole |
| Nelfinavir | drug interactions | Interacting Agent: Antiviral agents; Examples: Fosamprenavir, nelfinavir, ritonavir |
| Nifedipine | drug interactions | Interacting Agent: Calcium channel blockers; Examples: Nifedipine, nimodipine, nisoldipine, verapamil |
| Nimodipine | drug interactions | Interacting Agent: Calcium channel blockers; Examples: Nifedipine, nimodipine, nisoldipine, verapamil |
| Nisoldipine | drug interactions | Interacting Agent: Calcium channel blockers; Examples: Nifedipine, nimodipine, nisoldipine, verapamil |
| Omeprazole | drug interactions | Interacting Agent: Gastric acid reducing agents; Examples: H 2 antagonists (cimetidine), omeprazole |
| Oxcarbazepine | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate |
| Paclitaxel | drug interactions | Interacting Agent: Antineoplastic agents; Examples: Irinotecan, paclitaxel, teniposide |
| Paroxetine | drug interactions | Interacting Agent: Other; Examples: Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D |
| Phenobarbital | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Phenobarbital, valproate sodium Valproate sodium and valproic acid are similar medications. … |
| Posaconazole | drug interactions | Interacting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, posaconazole, voriconazole |
| Praziquantel | drug interactions | … cyclosporine, digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine |
| Quetiapine | drug interactions | … digoxin, disopyramide, folic acid, methadone, mexiletine, praziquantel, quetiapine |
| Quinidine | drug interactions | Interacting Agent: Other; Examples: Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D |
| Rifampin | drug interactions | Interacting Agent: Other; Examples: Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. John’s wort The induction potency of St. … |
| Ritonavir | drug interactions | Interacting Agent: Antiviral agents; Examples: Fosamprenavir, nelfinavir, ritonavir |
| Rivaroxaban | drug interactions | Interacting Agent: Anticoagulants; Examples: Apixaban, dabigatran, edoxaban, rivaroxaban |
| Rocuronium | drug interactions | Interacting Agent: Neuromuscular blocking agents; Examples: Cisatracurium, pancuronium, rocuronium and vecuronium: resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular … |
| Sertraline | drug interactions | Interacting Agent: Antidepressants; Examples: Fluoxetine, fluvoxamine, sertraline |
| Simvastatin | drug interactions | Interacting Agent: Antilipidemic agents; Examples: Atorvastatin, fluvastatin, simvastatin |
| Sucralfate | drug interactions | … potency of St. John’s wort may vary widely based on preparation., sucralfate, theophylline |
| Sulfadiazine | drug interactions | Interacting Agent: Sulfonamides; Examples: Sulfamethizole, sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim |
| Theophylline | drug interactions | … St. John’s wort may vary widely based on preparation., sucralfate, theophylline |
| Ticagrelor | drug interactions | Interacting Agent: Antiplatelets; Examples: Ticagrelor |
| Topiramate | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Ethosuximide, felbamate, oxcarbazepine, methsuximide, topiramate |
| Trazodone | drug interactions | … methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin |
| Valproic acid | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Phenobarbital, valproate sodium Valproate sodium and valproic acid are similar medications. … |
| Vecuronium | drug interactions | Interacting Agent: Neuromuscular blocking agents; Examples: Cisatracurium, pancuronium, rocuronium and vecuronium: resistance to the neuromuscular blocking action of the nondepolarizing neuromuscular … |
| Verapamil | drug interactions | Interacting Agent: Calcium channel blockers; Examples: Nifedipine, nimodipine, nisoldipine, verapamil |
| Vigabatrin | drug interactions | Interacting Agent: Antiepileptic drugs; Examples: Carbamazepine, vigabatrin |
| Voriconazole | drug interactions | Interacting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole |
| Warfarin | drug interactions | … phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin |
Other labels that name phenytoin
- Acetaminophen and benzhydrocodone
- Acitretin
- Aminophylline
- Apremilast
- Aprepitant
- Armodafinil
- Aspirin and dipyridamole
- Atazanavir
- Auranofin
- Azithromycin
- Bazedoxifene and estrogens conjugated
- Brivaracetam
- Buprenorphine
- Bupropion
- Buspirone
- Busulfan
- Cabotegravir
- Cabozantinib
- Caffeine
- Calcitriol
- Canagliflozin
- Carbidopa and entacapone and levodopa
- Carmustine
- Cenobamate
- Clomipramine
- Cobicistat
- Cobimetinib
- Codeine
- Colesevelam
- Dapsone
- Darunavir
- Deferasirox
- Deflazacort
- Dexamethasone
- Dienogest and estradiol
- Dolutegravir
- Donepezil and memantine
- Dopamine
- Doravirine
- Dronedarone
- Drospirenone
- Elbasvir and grazoprevir
- Ensitrelvir
- Enzalutamide
- Erlotinib
- Erythromycin
- Eslicarbazepine
- Estazolam
- Ethinyl estradiol and ferrous bisglycinate and levonorgestrel
- Ethinyl estradiol and ferrous fumarate and levonorgestrel
- Ethinyl estradiol and levonorgestrel
- Ethinyl estradiol and norelgestromin
- Ethinyl estradiol and norgestimate
- Etonogestrel
- Etravirine
- Exemestane
- Fentanyl
- Fludrocortisone
- Folic acid
- Fosphenytoin
- Fostemsavir
- Gabapentin
- Ganaxolone
- Gefitinib
- Glimepiride
- Glipizide
- Hydrocodone
- Hydrocortisone
- Imipramine
- Istradefylline
- Ixazomib
- Ketorolac
- Lenacapavir
- Letermovir
- Leucovorin
- Levoleucovorin
- Levothyroxine
- Lidocaine
- Liothyronine
- Lithium
- Lurasidone
- Maribavir
- Meperidine
- Metformin
- Methylprednisolone
- Metronidazole
- Mifepristone
- Modafinil
- Multiple vitamins
- Nateglinide
- Nilutamide
- Nitisinone
- Norethindrone
- Oliceridine
- Ondansetron
- Oxycodone
- Palbociclib
- Pentobarbital
- Perampanel
- Prednisolone
- Procainamide
- Propranolol
- Quinine
- Ranolazine
- Rilpivirine
- Risperidone
- Roflumilast
- Rufinamide
- Selegiline
- Sirolimus
- Sofosbuvir
- Stiripentol
- Sufentanil
- Suvorexant
- Tacrolimus
- Tadalafil
- Temsirolimus
- Tenofovir alafenamide
- Thalidomide
- Thiotepa
- Tiagabine
- Tinidazole
- Toremifene
- Tramadol
- Triamcinolone
- Trimethoprim
- Vemurafenib
- Vilazodone
- Vinblastine
- Vincristine
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
What do FAERS reports show for phenytoin?
The FDA Adverse Event Reporting System holds 40,278 reports that list phenytoin among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 4,416 are coded as a death and 14,794 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as phenytoin?
20 other medicines are given the same way (oral) and in the same FDA class as phenytoin or labeled mainly for the same use (seizures and epilepsy), the same class first. Seizures and epilepsy lists all 27 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Gabapentin | Seizures and epilepsy | 87 labelers | $0.0218 per capsule 100 mg capsule | No current entry |
| Lamotrigine | Seizures and epilepsy | 50 labelers | $0.0268 per tablet 25 mg tablet | A presentation being discontinued |
| Divalproex | Seizures and epilepsy | 44 labelers | $0.194 per tablet 500 mg tablet | No current entry |
| Oxcarbazepine | Seizures and epilepsy | 43 labelers | $0.167 per tablet 300 mg tablet | No current entry |
| Zonisamide | Seizures and epilepsy | 20 labelers | $0.106 per capsule 100 mg capsule | No current entry |
| Valproic acid | Seizures and epilepsy | 19 labelers | $0.243 per capsule 250 mg capsule | Listed; available |
| Primidone | Seizures and epilepsy | 21 labelers | $0.0914 per tablet 50 mg tablet | No current entry |
| Felbamate | Seizures and epilepsy | 9 labelers | $1.00 per tablet 600 mg tablet | No current entry |
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does phenytoin compare with medicines for the same use?
6 side-by-side pages set phenytoin beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to phenytoin
- 20 medicines for the same use
- Other anti-seizure medicines
- the pharmacologic class, with prices and generics
- Phenytoin side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other