Voriconazole and Darunavir Interaction
Drug interaction information between Voriconazole and Darunavir.
Voriconazole and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Voriconazole and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir lowers the levels of voriconazole in your body. This can make the antifungal drug less effective at treating your infection.
FDA Label Information
voriconazole ↓ voriconazole Voriconazole is not recommended for patients receiving darunavir/ritonavir unless an assessment comparing predicted benefit to risk ratio justifies the use of voriconazole.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Darunavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Voriconazole's 50. In the moderate band specifically: Voriconazole has 9 (also Tretinoin, Midazolam, Lemborexant, Alosetron); Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel).
What mechanism field is on file for Voriconazole and Darunavir?
Darunavir lowers the levels of voriconazole in your body. This can make the antifungal drug less effective at treating your infection.
Darunavir carries more major-labeled pairs than Voriconazole
SPL source-record counts only. This page's band is moderate · classes on file: Voriconazole (Azole Antifungal); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Voriconazole's 8. This page itself is in the moderate band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other moderate peers for Voriconazole
- Tretinoin
- Midazolam
- Lemborexant
- Alosetron
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.