Voriconazole and Lurasidone Interaction
Drug interaction information between Voriconazole and Lurasidone.
Voriconazole and Lurasidone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Voriconazole and Lurasidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
FDA Label Information
Ergot Alkaloids (CYP450 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated Naloxegol (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased which may Increase the Risk of Adverse Reactions Contraindicated Tolvaptan (CYP3A4 Inhibition) Although Not Studied Clinically, Voriconazole is Likely to Significantly Increase the Plasma Concentrations of Tolvaptan Contraindicated Lurasidone (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Voriconazole is Likely to Significantly Increase...
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Pimozide major
- Ivabradine major
- Phenytoin major
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Lurasidone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Voriconazole has 8 (also Norethindrone, Rifampin, Pimozide, Ivabradine); Lurasidone has 5 (also Clarithromycin, Darunavir, Itraconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Voriconazole and Lurasidone?
Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
Voriconazole carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Voriconazole (Azole Antifungal); Lurasidone (Atypical Antipsychotic).
Voriconazole has 8 major-labeled pairs vs Lurasidone's 5.
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Norethindrone
- Rifampin
- Pimozide
- Ivabradine
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Clarithromycin
- Darunavir
- Itraconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.