What the FDA labels say about taking them together
Norethindrone and voriconazole
Norethindrone's FDA label of January 31, 2026 names voriconazole in its drug interactions section, and voriconazole's label names norethindrone too. The voriconazole label: “Monitoring for adverse reactions and toxicity related to voriconazole is recommended for concomitant administration with oral contraceptives.”
Check it at the source: the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the norethindrone label say about voriconazole?
Norethindrone label, drug interactionsSubstances increasing the systemic concentrations of HCs: Co-administration of certain HCs and strong or moderate CYP3A4 inhibitors such as itraconazole, voriconazole, fluconazole, grapefruit juice, or ketoconazole may increase the systemic concentrations of progestins, including norethindrone.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
What does the voriconazole label say about norethindrone?
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Oral Contraceptives containing ethinyl estradiol and norethindrone (CYP2C19 Inhibition); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Increased; Prevention or Management Recommendations: Monitoring for adverse reactions and toxicity related to voriconazole is recommended for concomitant administration with oral contraceptives.
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Oral Contraceptives containing ethinyl estradiol and norethindrone (CYP2C19 Inhibition); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Increased; Recommendations for Voriconazole Dosage Adjustment/Comments: Monitoring for adverse reactions and toxicity related to voriconazole is recommended when coadministered with oral contraceptives
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Norethindrone | Voriconazole | |
|---|---|---|
| Labeled for | Birth control | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.290 per tablet 5 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once