Voriconazole and Pimozide Interaction
Drug interaction information between Voriconazole and Pimozide.
Voriconazole and Pimozide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Voriconazole and Pimozide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole prevents your body from breaking down pimozide, which can lead to very high levels of the drug in your blood. This can cause dangerous and potentially fatal heart rhythm problems.
FDA Label Information
Pimozide, Quinidine, Ivabradine (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated because of potential for QT prolongation and rare occurrence of torsade de pointes.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Ivabradine major
- Phenytoin major
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Pimozide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Pimozide's 24. In the major band specifically: Voriconazole has 8 (also Norethindrone, Rifampin, Lurasidone, Ivabradine); Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Darunavir).
What mechanism field is on file for Voriconazole and Pimozide?
Voriconazole prevents your body from breaking down pimozide, which can lead to very high levels of the drug in your blood. This can cause dangerous and potentially fatal heart rhythm problems.
Pimozide carries more major-labeled pairs than Voriconazole
SPL source-record counts only. This page's band is major · classes on file: Voriconazole (Azole Antifungal); Pimozide (Typical Antipsychotic).
Pimozide has 12 major-labeled pairs vs Voriconazole's 8.
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Norethindrone
- Rifampin
- Lurasidone
- Ivabradine
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.