Voriconazole and Ivabradine Interaction
Drug interaction information between Voriconazole and Ivabradine.
Voriconazole and Ivabradine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Voriconazole and Ivabradine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole stops the body from breaking down ivabradine, which can lead to dangerously high levels of the drug in the blood. This increase can cause serious and potentially life-threatening heart rhythm problems.
FDA Label Information
Pimozide, Quinidine, Ivabradine (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated because of potential for QT prolongation and rare occurrence of torsade de pointes.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Phenytoin major
Ivabradine Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Digoxin moderate
- Diltiazem moderate
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Ivabradine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Ivabradine's 10. In the major band specifically: Voriconazole has 8 (also Norethindrone, Rifampin, Lurasidone, Pimozide); Ivabradine has 4 (also Darunavir, Itraconazole, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Voriconazole and Ivabradine?
Voriconazole stops the body from breaking down ivabradine, which can lead to dangerously high levels of the drug in the blood. This increase can cause serious and potentially life-threatening heart rhythm problems.
Voriconazole carries more major-labeled pairs than Ivabradine
SPL source-record counts only. This page's band is major · classes on file: Voriconazole (Azole Antifungal); Ivabradine (HCN Channel Blocker).
Voriconazole has 8 major-labeled pairs vs Ivabradine's 4.
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Norethindrone
- Rifampin
- Lurasidone
- Pimozide
4 major · 2 moderate · 4 minor · 10 total
- Other major peers for Ivabradine
- Darunavir
- Itraconazole
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.