What the FDA labels say about taking them together
Darunavir and omeprazole
Darunavir's FDA label of August 29, 2025 names omeprazole in its drug interactions section; the omeprazole labels PlainMeds reads (2) do not name darunavir. The darunavir label: “When omeprazole is co-administered with PREZISTA/ritonavir, monitor patients for decreased efficacy of omeprazole. Consider increasing the omeprazole dose in patients whose symptoms are not well controlled; …”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the darunavir label say about omeprazole?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Proton pump inhibitor: omeprazole; Effect on Concentration of Darunavir Or Concomitant Drug: ↓ omeprazole ↔ darunavir; Clinical Comment: When omeprazole is co-administered with PREZISTA/ritonavir, monitor patients for decreased efficacy of omeprazole. Consider increasing the omeprazole dose in patients whose symptoms are not well controlled; avoid use of more than 40 mg per day of omeprazole.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the omeprazole label say about darunavir?
Omeprazole's label (effective April 22, 2024) and its 1 other brand-application label do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Omeprazole | |
|---|---|---|
| Labeled for | HIV | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once