Darunavir and Omeprazole Interaction
Drug interaction information between Darunavir and Omeprazole.
Darunavir and Omeprazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir can lower the amount of omeprazole in your body, making the stomach medicine less effective at treating acid. This happens because of how the drugs interact during processing in the body.
FDA Label Information
Proton pump inhibitor: omeprazole ↓ omeprazole ↔ darunavir When omeprazole is co-administered with darunavir/ritonavir, monitor patients for decreased efficacy of omeprazole. Consider increasing the omeprazole dose in patients whose symptoms are not well controlled; avoid use of more than 40 mg per day of omeprazole.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Tacrolimus Topical moderate
- Aripiprazole minor
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Omeprazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Omeprazole's 27. In the moderate band specifically: Darunavir has 16 (also Fluticasone, Apixaban, Clopidogrel, Quetiapine); Omeprazole has 4 (also Clarithromycin, Clopidogrel, Tacrolimus Topical).
What mechanism field is on file for Darunavir and Omeprazole?
Darunavir can lower the amount of omeprazole in your body, making the stomach medicine less effective at treating acid. This happens because of how the drugs interact during processing in the body.
Darunavir carries more major-labeled pairs than Omeprazole
SPL source-record counts only. This page's band is moderate · classes on file: Darunavir (HIV Protease Inhibitor); Omeprazole (Proton Pump Inhibitor (PPI)).
Darunavir has 15 major-labeled pairs vs Omeprazole's 1. This page itself is in the moderate band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Fluticasone
- Apixaban
- Clopidogrel
- Quetiapine
1 major · 4 moderate · 22 minor · 27 total
- Other moderate peers for Omeprazole
- Clarithromycin
- Clopidogrel
- Tacrolimus Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.