Voriconazole and Midazolam Interaction
Drug interaction information between Voriconazole and Midazolam.
Voriconazole and Midazolam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Voriconazole and Midazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole blocks the enzyme that removes midazolam from your body, which can make the sedative effects much stronger.
FDA Label Information
Midazolam (CYP3A4 Inhibition) Significantly Increased Increased plasma exposures may increase the risk of adverse reactions and toxicities related to benzodiazepines.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Midazolam?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Midazolam's 39. In the moderate band specifically: Voriconazole has 9 (also Tretinoin, Lemborexant, Alosetron, Darunavir); Midazolam has 9 (also Ketoconazole, Verapamil, Erythromycin, Ranitidine).
What mechanism field is on file for Voriconazole and Midazolam?
Voriconazole blocks the enzyme that removes midazolam from your body, which can make the sedative effects much stronger.
Voriconazole carries more major-labeled pairs than Midazolam
SPL source-record counts only. This page's band is moderate · classes on file: Voriconazole (Azole Antifungal); Midazolam (Benzodiazepine).
Voriconazole has 8 major-labeled pairs vs Midazolam's 3. This page itself is in the moderate band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other moderate peers for Voriconazole
- Tretinoin
- Lemborexant
- Alosetron
- Darunavir
3 major · 9 moderate · 27 minor · 39 total
- Other moderate peers for Midazolam
- Ketoconazole
- Verapamil
- Erythromycin
- Ranitidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.