What the FDA labels say about taking them together
Darunavir and fluticasone
Darunavir's FDA label of August 29, 2025 names fluticasone in its drug interactions section; the fluticasone labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Co-administration with corticosteroids of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the fluticasone FDA label on DailyMed (effective December 19, 2024, Haleon US Holdings LLC).
What does the darunavir label say about fluticasone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Corticosteroids primarily metabolized by CYP3A: e.g. betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ corticosteroids; Clinical Comment: Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the fluticasone label say about darunavir?
Fluticasone's label (effective December 19, 2024) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (FLONASE ALLERGY RELIEF), Haleon US Holdings LLC, effective December 19, 2024 (SPL set b6134ba0-b70a-4eac-9a82-cef64b242c1d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Fluticasone | |
|---|---|---|
| Labeled for | HIV | Allergies, Asthma, Eczema (atopic dermatitis) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.243 per gram 0.05% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once