Darunavir and Fluticasone Interaction
Drug interaction information between Darunavir and Fluticasone.
Darunavir and Fluticasone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Fluticasone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir blocks the body from breaking down fluticasone, which can lead to very high steroid levels in your blood. This can cause serious hormone problems like Cushing's syndrome.
What To Do
Avoid using these drugs together if possible. If you must use them, your doctor will need to watch you closely for signs of steroid overdose or hormone issues.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Fluticasone Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
- Itraconazole minor
Frequently Asked Questions
Can I take Darunavir and Fluticasone together?
This is a moderate interaction. Avoid using these drugs together if possible. If you must use them, your doctor will need to watch you closely for signs of steroid overdose or hormone issues.
How serious is the interaction between Darunavir and Fluticasone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Darunavir and Fluticasone interact?
Darunavir blocks the body from breaking down fluticasone, which can lead to very high steroid levels in your blood. This can cause serious hormone problems like Cushing's syndrome.
Understanding the Darunavir and Fluticasone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Darunavir belongs to the HIV Protease Inhibitor class and Fluticasone belongs to the Corticosteroid class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir blocks the body from breaking down fluticasone, which can lead to very high steroid levels in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Darunavir has 101 total documented interactions on file in this dataset, and Fluticasone has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these drugs together if possible. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Darunavir or Fluticasone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.