Darunavir and Lovastatin Interaction
Drug interaction information between Darunavir and Lovastatin.
Darunavir and Lovastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Darunavir and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.
FDA Label Information
Lipid Modifying Agents: HMG-CoA reductase inhibitors: lovastatin, simvastatin ↑ lovastatin ↑ simvastatin Co-administration is contraindicated due to potential for serious reactions such as myopathy including rhabdomyolysis.
Darunavir Also Interacts With
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
- Dronedarone major
Lovastatin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
- Cyclosporine moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Lovastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Lovastatin's 30. In the major band specifically: Darunavir has 15 (also Sildenafil, Lurasidone, Pimozide, Midazolam); Lovastatin has 2 (also Nirmatrelvir/Ritonavir).
What mechanism field is on file for Darunavir and Lovastatin?
Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.
Darunavir carries more major-labeled pairs than Lovastatin
SPL source-record counts only. This page's band is major · classes on file: Darunavir (HIV Protease Inhibitor); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Darunavir has 15 major-labeled pairs vs Lovastatin's 2.
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Sildenafil
- Lurasidone
- Pimozide
- Midazolam
2 major · 17 moderate · 11 minor · 30 total
- Other major peers for Lovastatin
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.