Darunavir and Lovastatin Interaction
Drug interaction information between Darunavir and Lovastatin.
Darunavir and Lovastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Darunavir and Lovastatin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.
What To Do
Do not take these two drugs together because of the risk of serious side effects like muscle damage.
FDA Label Information
Lipid Modifying Agents: HMG-CoA reductase inhibitors: lovastatin, simvastatin ↑ lovastatin ↑ simvastatin Co-administration is contraindicated due to potential for serious reactions such as myopathy including rhabdomyolysis.
Darunavir Also Interacts With
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
- Dronedarone major
Lovastatin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
- Cyclosporine moderate
Frequently Asked Questions
Can I take Darunavir and Lovastatin together?
This is a major interaction. Do not take these two drugs together because of the risk of serious side effects like muscle damage.
How serious is the interaction between Darunavir and Lovastatin?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Darunavir and Lovastatin interact?
Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.
Understanding the Darunavir and Lovastatin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Darunavir belongs to the HIV Protease Inhibitor class and Lovastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Darunavir has 101 total documented interactions on file in this dataset, and Lovastatin has 30. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these two drugs together because of the risk of serious side effects like muscle damage. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Darunavir or Lovastatin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.