What the FDA labels say about taking them together
Tretinoin and voriconazole
Voriconazole's FDA label of February 26, 2026 names tretinoin in its drug interactions section; the tretinoin labels PlainMeds reads (4) do not name voriconazole. The voriconazole label: “Frequent monitoring for signs and symptoms of pseudotumor cerebri or hypercalcemia.”
Check it at the source: the tretinoin FDA label on DailyMed (effective May 17, 2024, Bausch Health US, LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the tretinoin label say about voriconazole?
Tretinoin's label (effective May 17, 2024) and its 3 other brand-application labels do not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Retin-A), Bausch Health US, LLC, effective May 17, 2024 (SPL set 9556d73d-c573-4e0a-9feb-764ce2d1107b), via openFDA; the full label on DailyMed
What does the voriconazole label say about tretinoin?
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by Voriconazole): Tretinoin (CYP3A4 Inhibition); Drug Plasma Exposure (C max and AUC τ): Although Not Studied, Voriconazole may Increase Tretinoin Concentrations and Increase the Risk of Adverse Reactions; Prevention or Management Recommendations: Frequent monitoring for signs and symptoms of pseudotumor cerebri or hypercalcemia.
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tretinoin | Voriconazole | |
|---|---|---|
| Labeled for | Acne | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.506 per gram 0.025% cream | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once