Voriconazole and Tretinoin Interaction
Drug interaction information between Voriconazole and Tretinoin.
Voriconazole and Tretinoin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Voriconazole and Tretinoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole stops the body from breaking down tretinoin, which can lead to high levels of the drug in your blood.
FDA Label Information
Tretinoin (CYP3A4 Inhibition) Although Not Studied, Voriconazole may Increase Tretinoin Concentrations and Increase the Risk of Adverse Reactions Frequent monitoring for signs and symptoms of pseudotumor cerebri or hypercalcemia.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Tretinoin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Tretinoin's 3. In the moderate band specifically: Voriconazole has 9 (also Midazolam, Lemborexant, Alosetron, Darunavir); Tretinoin has 2 (also Retinol).
What mechanism field is on file for Voriconazole and Tretinoin?
Voriconazole stops the body from breaking down tretinoin, which can lead to high levels of the drug in your blood.
Voriconazole carries more major-labeled pairs than Tretinoin
SPL source-record counts only. This page's band is moderate · classes on file: Voriconazole (Azole Antifungal); Tretinoin (Retinoid (Topical)).
Voriconazole has 8 major-labeled pairs vs Tretinoin's 0. This page itself is in the moderate band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
- Other moderate peers for Voriconazole
- Midazolam
- Lemborexant
- Alosetron
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.