Voriconazole and Rifampin Interaction
Drug interaction information between Voriconazole and Rifampin.
Voriconazole and Rifampin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Voriconazole and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to break down voriconazole much faster than normal. This makes the voriconazole level in your blood too low to effectively treat your infection.
Voriconazole Also Interacts With
- Norethindrone major
- Lurasidone major
- Pimozide major
- Ivabradine major
- Phenytoin major
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Rifampin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Voriconazole's 50. In the major band specifically: Voriconazole has 8 (also Norethindrone, Lurasidone, Pimozide, Ivabradine); Rifampin has 8 (also Darunavir, Bictegravir, Glecaprevir/Pibrentasvir, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Voriconazole and Rifampin?
Rifampin causes your body to break down voriconazole much faster than normal. This makes the voriconazole level in your blood too low to effectively treat your infection.
Rifampin's labeled portfolio outnumbers Voriconazole
SPL source-record counts only. This page's band is major · classes on file: Voriconazole (Azole Antifungal); Rifampin (Rifamycin Antibiotic).
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Norethindrone
- Lurasidone
- Pimozide
- Ivabradine
8 major · 26 moderate · 103 minor · 137 total
- Other major peers for Rifampin
- Darunavir
- Bictegravir
- Glecaprevir/Pibrentasvir
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.