What the FDA labels say about taking them together
Rifampin and voriconazole
Voriconazole's FDA label of February 26, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name voriconazole. The voriconazole label: “Contraindicated”
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the rifampin label say about voriconazole?
Rifampin's label (effective February 11, 2026) does not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the voriconazole label say about rifampin?
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Rifampin Results based on in vivo clinical studies generally following repeat oral dosing with 200 mg every 12 hours voriconazole to healthy subjects and Rifabutin (CYP450 Induction); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Significantly Reduced; Prevention or Management Recommendations: Contraindicated
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), contraindicationsCoadministration of Voriconazole for injection with rifampin, carbamazepine, long-acting barbiturates and St. John's Wort is contraindicated because these drugs are likely to decrease plasma voriconazole concentrations significantly [see Drug Interactions (7) and Clinical Pharmacology (12.3) ].
Voriconazole label (Xellia Pharmaceuticals USA LLC, January 11, 2023), drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Rifampin and Rifabutin (CYP450 Induction); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Significantly Reduced; Recommendations for Voriconazole Dosage Adjustment/Comments: Contraindicated
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Voriconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | $1.88 per tablet 200 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once