What the FDA labels say about taking them together
Apixaban and darunavir
Darunavir's FDA label of August 29, 2025 names apixaban in its drug interactions section; the apixaban labels PlainMeds reads (2) do not name darunavir. The darunavir label: “Due to potentially increased bleeding risk, dosing recommendations for co-administration of apixaban with PREZISTA/ritonavir depend on the apixaban dose. …”
Check it at the source: the apixaban FDA label on DailyMed (effective April 24, 2026, Cardinal Health 107, LLC); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the apixaban label say about darunavir?
Apixaban's label (effective April 24, 2026) and its 1 other brand-application label do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ELIQUIS), NDA202155 (Bristol Myers Squibb), as published by Cardinal Health 107, LLC, effective April 24, 2026 (SPL set a454cd24-0c6d-46e8-b1e4-197388606175), via openFDA; the full label on DailyMed
What does the darunavir label say about apixaban?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: apixaban; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ apixaban; Clinical Comment: Due to potentially increased bleeding risk, dosing recommendations for co-administration of apixaban with PREZISTA/ritonavir depend on the apixaban dose. Refer to apixaban dosing instructions for co-administration with P-gp and strong CYP3A inhibitors in apixaban prescribing information.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apixaban | Darunavir | |
|---|---|---|
| Labeled for | Atrial fibrillation, Blood clots (DVT and PE), Stroke prevention | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $5.52 per tablet 5 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once