Darunavir and Apixaban Interaction
Drug interaction information between Darunavir and Apixaban.
Darunavir and Apixaban have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Apixaban. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir blocks the proteins and enzymes that normally clear apixaban from your body, leading to higher levels of the blood thinner.
FDA Label Information
Anticoagulants : Direct Oral Anticoagulants (DOACs) apixaban ↑ apixaban Due to potentially increased bleeding risk, dosing recommendations for co-administration of apixaban with darunavir/ritonavir depend on the apixaban dose. Refer to apixaban dosing instructions for co-administration with P-gp and strong CYP3A inhibitors in apixaban prescribing information.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Carbamazepine moderate
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Apixaban?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Darunavir has 16 (also Omeprazole, Fluticasone, Clopidogrel, Quetiapine); Apixaban has 9 (also Clopidogrel, Aspirin, Warfarin, Carbamazepine).
What mechanism field is on file for Darunavir and Apixaban?
Darunavir blocks the proteins and enzymes that normally clear apixaban from your body, leading to higher levels of the blood thinner.
Darunavir carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Darunavir (HIV Protease Inhibitor); Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)).
Darunavir has 15 major-labeled pairs vs Apixaban's 0. This page itself is in the moderate band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Clopidogrel
- Quetiapine
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Aspirin
- Warfarin
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.