What the FDA labels say about taking them together
Lemborexant and voriconazole
Voriconazole's FDA label of February 26, 2026 names lemborexant in its drug interactions section; the lemborexant label PlainMeds reads does not name voriconazole. The voriconazole label: “Lemborexant (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro, but Drug Plasma Exposure Likely to be Increased Avoid concomitant use of VFEND with lemborexant.”
Check it at the source: the lemborexant FDA label on DailyMed (effective February 24, 2025, Eisai Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the lemborexant label say about voriconazole?
Lemborexant's label (effective February 24, 2025) does not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DAYVIGO), Eisai Inc., effective February 24, 2025 (SPL set 7074cb65-77b3-45d2-8e8d-da8dc0f70bfd), via openFDA; the full label on DailyMed
What does the voriconazole label say about lemborexant?
Voriconazole label, drug interactionsLemborexant (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro, but Drug Plasma Exposure Likely to be Increased Avoid concomitant use of VFEND with lemborexant.
Source: FDA drug label (Voriconazole, NDA208562), Xellia Pharmaceuticals USA LLC, effective January 11, 2023 (SPL set 9ec6eda2-2f15-423b-9ec6-819379a426e1), via openFDA
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lemborexant | Voriconazole | |
|---|---|---|
| Labeled for | Insomnia | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $11.57 per tablet 10 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once