Voriconazole and Lemborexant Interaction
Drug interaction information between Voriconazole and Lemborexant.
Voriconazole and Lemborexant have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Voriconazole and Lemborexant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole prevents the body from processing lemborexant correctly, which can cause the sleep medication to build up to unsafe levels.
FDA Label Information
Lemborexant (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Avoid concomitant use of VFEND with lemborexant.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Lemborexant Also Interacts With
- Fluconazole moderate
- Bupropion minor
- Verapamil minor
- Carbamazepine minor
- Clarithromycin minor
Frequently Asked Questions
What SPL severity band is on file for Voriconazole + Lemborexant?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Lemborexant's 11. In the moderate band specifically: Voriconazole has 9 (also Tretinoin, Midazolam, Alosetron, Darunavir); Lemborexant has 2 (also Fluconazole).
What mechanism field is on file for Voriconazole and Lemborexant?
Voriconazole prevents the body from processing lemborexant correctly, which can cause the sleep medication to build up to unsafe levels.
Voriconazole carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is moderate · classes on file: Voriconazole (Azole Antifungal); Lemborexant (Orexin Receptor Antagonist).
Voriconazole has 8 major-labeled pairs vs Lemborexant's 0. This page itself is in the moderate band, not the major band.
8 major · 9 moderate · 33 minor · 50 total
0 major · 2 moderate · 9 minor · 11 total
- Other moderate peers for Lemborexant
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.