Darunavir and Sildenafil Interaction
Drug interaction information between Darunavir and Sildenafil.
Darunavir and Sildenafil have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Darunavir and Sildenafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir increases the amount of sildenafil in your system, which can cause very low blood pressure or fainting.
FDA Label Information
avanafil, sildenafil, tadalafil, vardenafil ↑ PDE-5 inhibitors (only the use of sildenafil at doses used for treatment of erectile dysfunction has been studied with darunavir/ritonavir) Co-administration with darunavir/ritonavir may result in an increase in PDE-5 inhibitor-associated adverse events, including hypotension, syncope, visual disturbances and priapism. Use of PDE-5 inhibitors for pulmonary arterial hypertension (PAH): Co-administration with sildenafil used for PAH is contraindicated due to potential for sildenafil associated adverse reactions (which include visual disturbances,...
Darunavir Also Interacts With
- Lovastatin major
- Lurasidone major
- Pimozide major
- Midazolam major
- Dronedarone major
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Hydralazine/Isosorbide Dinitrate major
- Nirmatrelvir/Ritonavir major
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Sildenafil?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Sildenafil's 10. In the major band specifically: Darunavir has 15 (also Lovastatin, Lurasidone, Pimozide, Midazolam); Sildenafil has 6 (also Ketoconazole, Erythromycin, Itraconazole, Hydralazine).
What mechanism field is on file for Darunavir and Sildenafil?
Darunavir increases the amount of sildenafil in your system, which can cause very low blood pressure or fainting.
Darunavir carries more major-labeled pairs than Sildenafil
SPL source-record counts only. This page's band is major · classes on file: Darunavir (HIV Protease Inhibitor); Sildenafil (PDE5 Inhibitor).
Darunavir has 15 major-labeled pairs vs Sildenafil's 6.
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Lurasidone
- Pimozide
- Midazolam
6 major · 1 moderate · 3 minor · 10 total
- Other major peers for Sildenafil
- Ketoconazole
- Erythromycin
- Itraconazole
- Hydralazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.