Darunavir and Lurasidone Interaction
Drug interaction information between Darunavir and Lurasidone.
Darunavir and Lurasidone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Darunavir and Lurasidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir causes lurasidone to build up in the body to unsafe levels.
FDA Label Information
Antipsychotics: lurasidone ↑ lurasidone Co-administration is contraindicated due to potential for serious and/or life-threatening reactions.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Pimozide major
- Midazolam major
- Dronedarone major
Lurasidone Also Interacts With
- Clarithromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Lurasidone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Darunavir has 15 (also Lovastatin, Sildenafil, Pimozide, Midazolam); Lurasidone has 5 (also Clarithromycin, Itraconazole, Nirmatrelvir/Ritonavir, Voriconazole).
What mechanism field is on file for Darunavir and Lurasidone?
Darunavir causes lurasidone to build up in the body to unsafe levels.
Darunavir carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Darunavir (HIV Protease Inhibitor); Lurasidone (Atypical Antipsychotic).
Darunavir has 15 major-labeled pairs vs Lurasidone's 5.
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Pimozide
- Midazolam
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Clarithromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
- Voriconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.