Darunavir and Clopidogrel Interaction
Drug interaction information between Darunavir and Clopidogrel.
Darunavir and Clopidogrel have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir interferes with the body's ability to change clopidogrel into its active form, which means the drug cannot do its job to prevent clots.
FDA Label Information
clopidogrel ↓ clopidogrel active metabolite Co-administration of darunavir/ritonavir and clopidogrel is not recommended due to potential reduction of the antiplatelet activity of clopidogrel.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Clopidogrel?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Clopidogrel's 19. In the moderate band specifically: Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Quetiapine); Clopidogrel has 9 (also Omeprazole, Warfarin, Esomeprazole, Rifampin).
What mechanism field is on file for Darunavir and Clopidogrel?
Darunavir interferes with the body's ability to change clopidogrel into its active form, which means the drug cannot do its job to prevent clots.
Darunavir carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is moderate · classes on file: Darunavir (HIV Protease Inhibitor); Clopidogrel (Antiplatelet Agent).
Darunavir has 15 major-labeled pairs vs Clopidogrel's 0. This page itself is in the moderate band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Quetiapine
0 major · 9 moderate · 10 minor · 19 total
- Other moderate peers for Clopidogrel
- Omeprazole
- Warfarin
- Esomeprazole
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.