What the FDA labels say about taking them together
Clopidogrel and darunavir
Darunavir's FDA label of August 29, 2025 names clopidogrel in its drug interactions section; the clopidogrel label PlainMeds reads does not name darunavir. The darunavir label: “Co-administration of PREZISTA/ritonavir and clopidogrel is not recommended due to potential reduction of the antiplatelet activity of clopidogrel.”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the clopidogrel label say about darunavir?
Clopidogrel's label (effective May 30, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the darunavir label say about clopidogrel?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: clopidogrel; Effect on Concentration of Darunavir Or Concomitant Drug: ↓ clopidogrel active metabolite; Clinical Comment: Co-administration of PREZISTA/ritonavir and clopidogrel is not recommended due to potential reduction of the antiplatelet activity of clopidogrel.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Darunavir | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once